Báo cáo y học: " b-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryo" docx

... protein. The appearance of protein and peptide-reactive antibodies was examined regularly in mothers before, during and after delivery. The aim of this study was twofold; first, to determine whether ... immunoassays. JH was involved in the analysis of the immunoassay results. HD per- formed and analyzed the immunoassays. VR performed and analyzed the immunoassays...

Ngày tải lên: 09/08/2014, 07:20

... Access b-Lapachone induces heart morphogenetic and functional defects by promoting the death of erythrocytes and the endocardium in zebrafish embryos Yi-Ting Wu 1 , Che Yi Lin 1 , Ming-Yuan Tsai 2 , ... cell death of erythrocytes and the endocardium in zebrafish embryos by b-lapachone is mediated through an NQO1- and calcium-dependent...

Ngày tải lên: 10/08/2014, 10:20

... mediated by Rho kinase and the other by the Ca 2+ -dependent activation of MLC kinase. These two pathways could be activated independ- ently of each other, depending on the type and concen- tration of ... rearrangements, by inhibiting actin assembly and focal adhesion in many cell types [8,9] through the decreased phosphorylation of various proteins [10,11] inclu...

Ngày tải lên: 21/02/2014, 01:21

... level only after 60 min (Fig. 1). Pyp1p and Pyp2p phosphatases appear to play a key role in the dephosphorylation of the osmotic stress-activated Sty1p [20]. Interestingly, however, the Sty1p activation ... shock induced a quick and transient phosphorylation of Sty1p that became dephosphorylated within 60–90 min. This is likely due to the activity of threonine-phosphatases...

Ngày tải lên: 08/03/2014, 09:20

... of immune/inflammatory responses. The appeal of statin therapy in chronic inflammatory disease is further enhanced by accumulating evidence that statins might influence bone metabolism (reviewed by Bauer ... metabolites in this pathway include farnesyl pyrophosphate and geranylgeranyl pyrophosphate, which are required for post-translational prenylation of a range of moieti...

Ngày tải lên: 09/08/2014, 01:23

... disease or events (heart attack and angina, coronary heart disease, coronary by- pass surgery, and stroke were included, but only if they occurred after RA had developed). The presence of traditional ... publication by Turesson and colleagues [2]. The real importance of this study, however, may lie in the final analysis, presented in Table 5 of their paper, which i...

Ngày tải lên: 09/08/2014, 10:22

... reasons, which in order of significance were: febrile situations, including infections of the respiratory, gastrointestinal and urinary system, problems with the regulation of antiplatelet and antithrombotic ... care. Introduction Every physician employed in the practice of heart sur- gery is aware of the fact that the psychological condition of a heart patie...

Ngày tải lên: 10/08/2014, 09:22

... using foam than when using gauze. NPWT using foam may relieve tension on the caval and lung veins in the bottom of the thoracic cavity, thereby decreasing the filling pressure in the right and ... foam may relieve tension on the caval and lung veins at the back of the thoracic cavity, thereby decreasing the filling pressure in the right and left atria. Th...

Ngày tải lên: 10/08/2014, 09:23

... all of the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. MK contributed to study concept and design, to analysis and interpretation ... sponsor. SM, AQ, and NK of Johnson and Johnson met authorship criteria by participating in the study design, analysis of results, interpretation of...

Ngày tải lên: 25/10/2012, 10:02

... injury such as gut and liver I/R injury 22 . This process is as- sociated with activation of inflammatory reaction, including the increased activity of NF-κB and the in- creased inflammatory mediators ... which infiltrate the lungs during endotoxemia, produce cytokines, such as interleu- kin-1β and TNF-α, and play a key role in the devel- opment of ALI by releas...

Ngày tải lên: 25/10/2012, 11:00