Báo cáo y học: " Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells" docx

... generating activity of HL-60 Cells Utilizing the induced differentiation of HL-60 promyelo- cytic leukemia cells as a model of myeloid maturation, we examined the expression and location of Rac and PAK. The interaction ... differenti- ation of HL-60 cells induced with ATRA. Induction of Rac and PAK HL-60 cells were treated with 1 l M ATRA for a week, an...

Ngày tải lên: 31/03/2014, 15:20

... participated in the conception and design of the project and in the analysis and interpretation of data and contributed substantially to the drafting of the manuscript. VFP partici- pated in the ... not significant in the univariate analysis and had no impact on the frequency of the metabolic syndrome. Conclusion In summary, this study suggest...

Ngày tải lên: 09/08/2014, 01:22

... for analysis was the higher of the two knees. We define generalized OA (GOA) by the hypothesis that OA found in the hand is an indicator of disease in other large joints, including the spine. An individual ... CRP, pyridinoline, YKL-40, MMP-3 and TIMP-1 levels each related to at least one of the radiographic gradings. Furthermore, pyridinoline related to every type...

Ngày tải lên: 09/08/2014, 01:23

... citation purposes) effects of the different NSAIDs should be consistent in vitro and in vivo. The direct negative effects of indomethacin are mainly reflected by an inhibition of proteoglycan synthesis ... features in terms of proteoglycan turnover (Table 1): low proteoglycan synthesis, high proteoglycan release (both newly formed pro- teoglycans and reside...

Ngày tải lên: 09/08/2014, 07:20

... one of which is N-acetylation; the result- ing N-acetylglucosamine can modify several proteins by cou- pling itself to the serine or threonine residues of those proteins. These include kinases, ... subunit, namely p65 (data not shown). The decreased phosphorylation MAPKs may be explained by the role played by glucosamine in O-glycosylation of some proteins. Glucosamine, when it ente...

Ngày tải lên: 09/08/2014, 10:21

... will have an increased prevalence of each of the individual components of the metabolic syndrome (dyslipidaemia, hypertension, hyperg- lycaemia, and central obesity) as well as the metabolic syn- drome ... It is therefore possible that, in RA patients, alterations in body fat/muscle may have already occurred as part of the dis- ease process and thus any addition...

Ngày tải lên: 09/08/2014, 13:22

... therapy in a routine health service setting in Jinja, Uganda Shabbar Jaffar* 1 , Josephine Birungi 2 , Heiner Grosskurth 3 , Barbara Amuron 3 , Geoffrey Namara 3 , Christine Nabiryo 2 and Alex ... Geoffrey Namara - geoffrey.namara@mrcuganda.org; Christine Nabiryo - cnabiryo@tasouganda.org; Alex Coutinho - acoutinho@idi.co.ug * Corresponding author Abstract In a rou...

Ngày tải lên: 10/08/2014, 05:21

... Central Page 1 of 12 (page number not for citation purposes) Journal of Circadian Rhythms Open Access Research Glycogen synthase kinase 3, circadian rhythms, and bipolar disorder: a molecular link ... the pathophysiology of affective disorders [6]. While there are many differences in the molecular and genetic details of the circadian machinery in...

Ngày tải lên: 10/08/2014, 09:20

... of 13 RESEARCH Open Access Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells Jiin-Haur Chuang 1,2 , Hui-Ching Chuang 2 ,3 , ... pathway is implicated in the selective cytotoxicity of TLR3 agonist towards high TLR3- expressing NB cells. Keywords: neuroblastoma, toll-like receptor...

Ngày tải lên: 10/08/2014, 10:20

... activation by plasma of five volunteers before and after five days intake of 200 mg mari-time pine bark extract (Pycnogenol)Figure 3 Inhibition of LPS-induced NF-κB activation by plasma of five volunteers ... before and after five days intake of 200 mg maritime pine bark extract (Pycnogenol)Figure 2 Inhibition of LPS-induced matrix metal...

Ngày tải lên: 11/08/2014, 08:21

... Corresponding author Abstract Proteinase-activated receptor 2 (PAR-2), activated by trypsin and other serine proteinases, is a key initiator of inflammatory responses in the intestine of mammals. Atlantic ... influenced by increased luminal proteinase activity rather than the release of proteinases such as tryptase [22]. Increased luminal trypsin-like activity in the dist...

Ngày tải lên: 11/08/2014, 08:22

... chemokines and cytokines by fibroblasts, which subsequently can increase the inflammatory infiltration of the tissue. In this study, IFNa2 upregulated TLR3 and T LR3-induced IL-6 production. The increase ... expression in systemic sclerosis. J Invest Dermatol 2010, 130 :25 83- 25 93. doi:10.1186/ar3221 Cite this article as: Agarwal et al.: Toll-like receptor 3 upregulation...

Ngày tải lên: 12/08/2014, 15:22

... Ishikawa K, Tsujimoto H, Nakai M, Mingle AJ, Osei-Kwasi M, Aggrey SE, Nettey VB, Afoakwa SN, Fukasawa M, Kodama T: Isolation and characterization of HIV-2 from an AIDS patient in Ghana. AIDS ... was isolated from human cells using an RNA extraction kit, SepaGene (Sanko-Junyaku Inc., Tokyo, Japan), in accordance with the manufacturer's protocol. cDNA for the total cellular RNA w...

Ngày tải lên: 13/08/2014, 05:21

... set out to investigate the contri- bution of DC in infection of these T cell subsets. We found that CCR5-using (R5) HIV-1 is efficiently transmitted to T EM cells but not to T N cells. Transmission ... Access Research Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell-mediated HIV-1 transmission...

Ngày tải lên: 13/08/2014, 09:20

... Conflict and Health 2010, 4:14 http://www.conflictandhealth.com/content/4/1/14 Page 9 of 9 RESEARC H Open Access The mental health of populations directly and indirectly exposed to violent conflict ... populations directly and indirectly exposed to violent conflict in Indonesia. Conflict and Health 2010 4:14. Submit your next manuscript...

Ngày tải lên: 13/08/2014, 14:20