Báo cáo y học: " Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects" pps

... 2010.08.08; Published: 2010.08.11 Abstract Objective: To investigate predictors < /b> of < /b> hepatic < /b> steatosis < /b> in < /b> HBeAg-negative < /b> chronic < /b> hepatitis < /b> B (CHB) patients and their diagnostic values in < /b> hepatic < /b> inflammation ... â Ivyspring International Publisher. All rights reserved Research Paper Predictors < /b> of < /b...

Ngày tải lên: 25/10/2012, 11:48

... absence of detectable HBV DNA at the time of OLT and absence of reinfection for a minimum of 6 months post-OLT. After one year, reinfection occurred in 20% of patients in each group, but the finding ... 3. HBV Reinfection of Allografts Two mechanisms have been implicated in allograft reinfection: 1) rapid reinfection by HBV in the circulation of the recipient...

Ngày tải lên: 02/11/2012, 11:17

... the involvement of lysine- containing sequences in the acti- vation mechanism. Involvement of lysine residues contained within a 1 CB6 peptides In order to localize lysine residues in sequences involved ... derived from jararhagin disin- tegrin) is essential for binding to the I domain of a 2 integrins [24]. Similarly, members of the lysine threo- nine–serine (KTS)–di...

Ngày tải lên: 07/03/2014, 06:20

... 18:55 http://www.jbiomedsci.com/content/18/1/55 Page 7 of 8 RESEARC H Open Access Involvement of mTOR signaling in sphingosylphosphorylcholine-induced hypopigmentation effects Hyo-Soon Jeong 1 , Seung Hoon Lee 1 , Hye-Young Yun 1 , Kwang Jin ... activity induced by a-MSH in B16 melanoma cells, indicating that SPC blocks the transcription of MITF (Figure 2B). The mTOR s...

Ngày tải lên: 10/08/2014, 10:20

... ROS, and the integrity of cytoskeleton to play a key role in adhesion-induced activation of Met and EGFR were excluded. Met and EGFR are independently activated upon cell adhesion As Met and ... NaCl, 10% glycerol and 1 mM Na 3 VO 4 ) containing protease inhibitors (1 mM phenylmethylsulfonyl fluoride, 0.2 trypsin inhibitory units/ml aprotinin, and 20 àg/ml l...

Ngày tải lên: 10/08/2014, 10:20

... this article as: Ypsilantis and Tisi: Involvement of the genicular branches in cystic adventitial disease of the popliteal artery as a possible marker of unfavourable early clinical outcome: a case ... Cystic adventitial disease of the popliteal artery. J Vasc Surg 2009, 49(5):1324. 8. Crolla RM, Steyling JF, Hennipman A, Slootweg...

Ngày tải lên: 11/08/2014, 12:20

... 12:12 http://respiratory-research.com/content/12/1/12 Page 2 of 12 sICAM-1 and LPS interact synergistically to increase cytokine elaboration by AMs. Taken together, these find ings imply a signi ficant, unique role for sICAM-1 in modulating the inflammatory ... frequent in the SPC -sICAM-1 mice versus wild-type mice (73% and 36%, respectively), suggesting a defect in the a...

Ngày tải lên: 12/08/2014, 13:22

... distribution in chronically hypoxic animals. J Appl Physiol 1977, 42:174-8. doi:10.1186/1465-9921-12-60 Cite this article as: Dahal et al.: Involvement of mast cells in monocrotaline-induced pulmonary hypertension ... a role in cardiac remodeling in hypertension- induced heart failure. J Mol Cell Cardiol 2008, 45:779-86. 15. Okayama Y, Ra C, Saito H: Role of mast ce...

Ngày tải lên: 12/08/2014, 13:22

... sensitization of murine bronchial smooth muscleFigure 2 Acetylcholine (ACh)-induced Ca 2+ sensitization of murine bronchial smooth muscle. (A) A typical recording of contraction induced by ... to understand changes in the contractile signaling of airway smooth muscle cells associated with the disease. Smooth muscle contraction including airways is mainly regula...

Ngày tải lên: 12/08/2014, 18:21

... 5'-TCTGGTT- GGAATGGTGACAACATGC-3' and 5'-CCAGGAAGAGCT- TCACTCAAAGCTT-3'; for GAPDH, 5'- ACCACAGTCCATGCCATCAC-3' and 5'-TCCACCACCCT- GTTGCTGTA-3'; for β-actin: ... cells was explained by hypermethylation of the 5'-LTR [18]. Binding of CREB and pCREB to the HTLV-1 enhancer CREB has been implicated as the primary player in both basal a...

Ngày tải lên: 12/08/2014, 23:21

... non- phosphorylated proteins of Akt. The targeted mutation gene of the Akt mutant is Akt1 , and the Akt antibody used for the western blot assay reacted with Akt1 , Akt2 , and Akt3 . The masking of specific Akt ... that activation of the serine/threonine kinase/protein kinase B (Akt) and endothelial nitric oxide synthase (eNOS) pathways was also involved in...

Ngày tải lên: 13/08/2014, 08:20

... func- tion in Saccharomyces cerevisiae. Science 1990, 247:464-467. 90. Shima F, Okada T, Kido M, Sen H, Tanaka Y, Tamada M, Hu CD, Yamawaki-Kataoka Y, Kariya K, Kataoka T: Association of yeast adenylyl ... Kinoshita K, Amagasaki T, Ikeda S, Suzuyama J, Toriya K, Nishino K, Tagawa M, Ichimaru M, Kamihira S, Yamada Y, et al.: Preleukemic state of adult T cell leukemia: abnormal T lymph...

Ngày tải lên: 13/08/2014, 09:20

... [Fig. 3A] . This was observed either by modifying the polymerising actin itself, by Cyto D action, or by inhibiting one key GTP binding protein involved in a molecular pathway that leads to actin ... purposes) Engagement of small GTP binding proteins in HIV-1 releaseFigure 3 Engagement of small GTP binding proteins in HIV-1 release. Jurkat HIV-1 infected ce...

Ngày tải lên: 13/08/2014, 09:21

... gp120-independent HIV- 1 infection We previously reported that by employing a gp120-inde- pendent infection mechanism, HIV- 1 virus infected sev- eral CD4(-) cell lines, including oral cell lines ... including CXCR4 and CCR5, on the surface of CD4(-) cells [15-19], and that this binding initiates HIV entry into CD4(-) cells. Therefore, gp120 would be a key protein for HIV...

Ngày tải lên: 13/08/2014, 09:21

... OVA- induced increase in cough reflex sensitivity only in sen- sitized guinea pigs, but it did not affect the normal cough reflex sensitivity in non-sensitized guinea pigs. Our initial hypothesis ... the iNOS inhibition experiment using NOS inhibitors, in non-sen- sitized guinea pigs with normal cough reflex sensitivity and in OVA-sensitized guinea pi...

Ngày tải lên: 13/08/2014, 10:20