Báo cáo y học: "Mesenchymal stem cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cell" ppsx

... strongly support the hypothesis that Bax-induced lipid oxidation is directly related to Bax-killing efficiency. Bax-induced lipid peroxidation is poorly related to Bax-induced ROS production Madeo ... supporting further the hypothesis that Bax actually induces lipid peroxidation. Mitochondrial lipid oxidation is involved in cell death kinetics Chatterjee et al. [32] s...

Ngày tải lên: 23/03/2014, 21:20

... Winslet M, Seifalian A: Stem cells and cancer: an overview. Stem Cell Rev 2007, 3(4):249-55. 4. Huntly B, Gilliland D: Leukaemia stem cells and the evolution of cancer- stem- cell research. Nat Rev ... exists and every single cancer cell has the capacity of initiation and progression. Cancer stem cell hypothesis suggests that targeted therapy to cancer stem cells, n...

Ngày tải lên: 18/06/2014, 19:20

... of cancer stem cells. Thus we propose a horizontal hierarchy that com- prises precancerous stem cells, primary cancer stem cells, migrating cancer stem cells and chemoradioresis- tant cancer stem ... unclear. Relationships among cancer stem cell subsets Up to now, precancerous stem cells, primary cancer stem cells and migrating cancer stem cells have be...

Ngày tải lên: 20/06/2014, 03:20

... reconstitution. These and other studies gave us a good and enduring operational definition for stem cells: those cells that when introduced Opinion The ‘stem cell’ concept: is it holding us back? Arthur ... burning - but it happens that no substance with definite physical charac- teristics has ever been found that satisfies this operational definition. Indeed, it was...

Ngày tải lên: 06/08/2014, 19:21

... for severe systemic lupus erythematosus of long duration. Lupus 1997, 6:545-548. 2. Burt RK, Traynor A, Ramsey-Goldman R: Hematopoietic stem- cell transplantation for systemic lupus erythematosus. ... transplantation: a phase I study. Lancet 2000, 356: 701-707. 4. Traynor A, Burt RK: Haematopoietic stem cell transplantation for active systemic lupus erythematos...

Ngày tải lên: 09/08/2014, 01:23

... out NK cytotox- icity assays and manuscript preparation. EHG carried out statistical analysis and manuscript preparation. TBG car- ried out patient referral, clinical data analysis and manu- script ... http:/ /arthritis- research.com/content/7/1/R30 R30 Vol 7 No 1 Research article Natural killer cell dysfunction is a distinguishing feature of systemic onset juvenile...

Ngày tải lên: 09/08/2014, 06:22

... lymphocytes of patients with com- mon variable immunodeficiency (CVI) produce reduced levels of interleukin-4, interleukin-2 and interferon-gamma, but pro- liferate normally upon activation by ... for dendritic cells (DCs) in the generation of immunoglobulin-secreting plasma cells. In the work reported herein, we analyzed the frequency of peripheral blood plasmacytoid DCs (pDCs) a...

Ngày tải lên: 09/08/2014, 06:23

... an anti-inflammatory type [26]. This relative deviation of the cytokine response, caused either by decreased Th1-type cytokines and/ or by enhanced Th2-type cytokines leading to the regression of an autoimmune ... anti-inflammatory cytokines over pro- inflammatory cytokines in response to Bhsp65 To test and compare the T cell proliferative and cytokine response...

Ngày tải lên: 09/08/2014, 10:20

... cardiac injuries, at least partially by shifting the microenvironment at the injury sites from proinflammatory to anti-inflammatory [55-57]. In a murine pulmonary fibrosis model, MSCs inhibited ... charac- terized in vitro by their extensive proliferative ability in an uncommitted state while retaining the potential to differentiate along various lineages of mesenchymal origin, includin...

Ngày tải lên: 09/08/2014, 13:22

... Sox9 staining patterns were mainly nuclear in normal cartilage (Figure 2), but Sox9 staining in OA clusters was present in both the cytoplasm and nucleus, or Figure 3 Stem cell markers in human ... (OA) articular cartilageStem cell markers in human osteoarthritis (OA) articular cartilage. (a) Safranin O and Notch-1 staining in clusters (10ì and 40ì). (b) Sa...

Ngày tải lên: 09/08/2014, 14:21

... cell transplantation ameliorates motor function deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells. Journal of Biomedical Science 2011 18:54. Submit your next manuscript ... deterioration of spinocerebellar ataxia by rescuing cerebellar Purkinje cells You-Kang Chang 1,2,3 , Ming-Hsiang Chen 4 , Yi-Hung Chiang 1,5 , Yu-Fan...

Ngày tải lên: 10/08/2014, 10:20

... Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells. Transplantation 2003, 76:1208-1213. 60. Dormady SP, Bashayan ... Access Review Mesenchymal stem cells avoid allogeneic rejection Jennifer M Ryan 1 , Frank P Barry 2 , J Mary Murphy 2 and Bernard P Mahon* 1 Address: 1 Institute of Immunology...

Ngày tải lên: 11/08/2014, 08:21

... underlying the possible in vivo immuno modulatory eff ects of MSCs remain a critical and unresolved question. By comparing side by side the eff ects of MSCs in vitro and in vivo, the study by ... Diaz F, Inostroza C, Rojo D, Mönckeberg G, Figueroa FE: Autologous mesenchymal stem cell treatment increased T regulatory cells with no e ect on disease activity in two systemic lu...

Ngày tải lên: 12/08/2014, 14:21

... tissue derived mesenchymal stem cells; HD: hematopoietic differentiated cells; AIDS: acquired immune deficiency syndrom e; HAART: highly active anti-retroviral therapy; HPCs: hematopoietic progenitor ... fusion to cellular membranes, thus facilitating entry into hematopoietic cells [4]. Although the peripheral blood -derived hematopoietic progenitor cells (HPCs) can expre...

Ngày tải lên: 13/08/2014, 01:20

... Tat RNA silencing suppressor activity contributes to perturbation of lymphocyte miRNA by HIV-1. Retrovirology 2011 8:36. Submit your next manuscript to BioMed Central and take full advantage of: ... in miRNA profile is observed by ablation of Vpr/Vif The possibility that HIV-1 manipulation of host miRNA contributes to HIV-1 induced cell cycle delay was p...

Ngày tải lên: 13/08/2014, 01:20