... actin (ACTG2), and actin cross-linking pro-teins such as filamin (FLNC), tropomyosin (TPM2), andtensin (TNS). Other iris/ciliary body signature genes haveknown roles in myosin phosphorylation ... organelles, including nuclei.Genes encoding the subunits of crystallins, the predominantstructural proteins in the lens, were prominent in the lens sig-nature, including subunits for crystallin alpha ... the distinctive expression pattern of these tissues (Fig-ure 2b). These genes encoded enzymes involved in melanogenesis, including tyrosinase (TYR), tyrosinase-related protein 1 (TYRP1), and...