Báo cáo y học: "Technical phosphoproteomic and bioinformatic tools useful in cancer research" potx

... spec- trometry via SILAC and immunoaffinity purification of tyrosine phosphorylated peptides to profile candidate SRC-substrates induced by the CSF-1R tyrosine k inase by comparing the phosphotyrosine-containing ... combined with IMAC and resulted in greater recovery and identification by MS of interest- ing phosphorylated peptides originating from yeast pher- omone signalling pathway...

Ngày tải lên: 10/08/2014, 09:22

... affected initially, and sepsis leads to severe injury in lung tissue [5]. It has been shown that pericytes in lung tissue produce proinflammatory cytokines in response to lipopolysaccharide ... activities and serum proinflammatory cytokine (TNF-α, IL-1β) le- vels were evaluated by enzyme linked immunosor- bent assay (ELISA) using commercially available kits according to the man...

Ngày tải lên: 25/10/2012, 11:18

... conducted in an Italian oncology setting. Taking together the promising findings from our study and the literature, need clearly results for inclusion of physical activity programs in comprehensive, ... preliminary evidence for the safety, feasibility, and efficacy of exercise training in breast cancer survivors. The aim of this study was to assess the association between ph...

Ngày tải lên: 08/08/2014, 16:23

... is an inflammatory disease involving joints and other systems including salivary glands. To assess NO production in RA patients, we compared levels of serum, urine, and salivary nitrite and nitrate ... NO in the pathogenesis of joint inflammation. Rodents in animal models of arthritis gener- Figure 3 NOx/creatinine ratios in urine and serumNOx/creatinine ratios in urine and...

Ngày tải lên: 09/08/2014, 08:22

... in elucidating the crosstalk between the immune system and bone and in uncovering the mechanism by which sex-steroids, infection and inflammation lead to bone loss by disregulating T lymphocyte ... approximately 50% of the increase in the number of T cells in the periphery, while the remaining 50% is due to enhanced peripheral expansion. Similarly, thymectomy decreases by approx...

Ngày tải lên: 09/08/2014, 10:20

... resulted in invasion of the thymus by day 14; accompanied by severe thymic atro- phy[17]. In humans, postmortem studies show thymic involu- tion in the severely malnourished[18]. Furthermore, cytokines ... Hebeishy NA, Rahmy AI: A post- mortem study of the thymolymphatic system in protein energy malnutrition. J Trop Med Hyg 1982, 85:109-114. 19. Bodey B, Bodey B Jr, Siegel SE, Kaiser...

Ngày tải lên: 10/08/2014, 05:21

... of subclinical lipoatro- phy. Our findings would also suggest that abdominal adi- posity increases more quickly in HIV-infected men with clinical lipodystophy, compared to those HIV-infected men ... agents and 34 due to diabetes, and 35 due to inconsistent antiretroviral therapy level in the 2 years preceding the first clinical evidence of lipodystrophy. Of the remaining 77 men, match...

Ngày tải lên: 10/08/2014, 05:21

... treatment and disease Longitudinal changes in serum chemistry were exam- ined at different stages of disease and treatment and revealed an initial increase in BUN and creatinine and decrease in phosphorus, ... features of ART nephropathy. Ectasia of renal tubules containing eosinophilic proteinaceous material (tubular proteinosis) (A) and focal lymphocytic infiltrate (B). Mi...

Ngày tải lên: 10/08/2014, 05:21

... study. RC participated in the electron microscopy. YM participated in the protein analysis (western blot and immunostaining). YS carried out the interpretation of the findings. CI participated in ... alcohol ingestion. Cellularity (A and B, stained with hematoxyllin) and capillary network (C and D, stained for CD31) in the left ventricular myocardium. A and C, are from the c...

Ngày tải lên: 10/08/2014, 10:20

... resonance imaging. Intraoperative palpation of the left lateral wall was guided by the cardiac MRI and CT findings and confirmed the presence of focally thinned and weakened myocardium, covered by epicardial ... and any accompanying images. A copy of the written consent is available for review by the Editor -in- Chief of this journal. Competing interests The authors declare that they...

Ngày tải lên: 10/08/2014, 10:20