Báo cáo y học: "A filter-based feature selection approach for identifying potential biomarkers for lung cancer" pot

... specified by a set of features () yxf i , , where features typically take the value of either 0 or 1 (Berger et al., 1996). More precisely, we want to maximize () () ( ) ( ) ( ) xypxypxppH yx log ~ , ∑ −= ... University of California, Berkeley. Vladimir Vapnik. 1995. The Nature of Statistical Learning Theory. Springer, New York, NY, USA. Darby Wong, Mari Ostendorf, Jeremy G. Kahn....

Ngày tải lên: 17/03/2014, 04:20

... study a feature- based approach that basically integrates entity related information with context information. 3.1 Classification Features The classification is based on the following four types ... merged into three coarser structures. z Entity Features Entity types and subtypes are concerned. z Entity Context Features These are character-based features. We consider both internal...

Ngày tải lên: 20/02/2014, 09:20

... generally if the data depart dramati- cally from multivariate normality, results may be mis- leading and difficult to interpret [31]. Our dataset was tested for conformity to multivariate normality ... extensively researc hed [2,6,8-10], no study to date has looked at the potential impact of the non-CpG methylome on the genome and its mutagenesis; in particular, methylated non-CpG cytosin...

Ngày tải lên: 09/08/2014, 22:24

... Chesney M, Child C, Wu AW, Friedland G for the Terry Beirn Community Programs for Clinical Research on AIDS: Quality of life in HIV-infected individuals receiving antiretroviral therapy is related ... in social psychology. Edited by: Reis HT & Judd CM. New York: Cambridge University Press; 2000:339-369[http://en.wikipedia.org/wiki/Discriminant_validity]. 12. Kinnear TC, Taylor JR: Mar...

Ngày tải lên: 10/08/2014, 05:21

... encephalopathy and coagulopathy. On hospital day 13, he developed res- piratory failure and was transferred to the ICU but he died of multiorgan failure the next day. An autopsy revealed coronary artery ... of corticosteroids highlighting the utility of "Hy's rule" in identifying DILI patients with a potentially poor prognosis. The primary management of DILI includes the iden...

Ngày tải lên: 11/08/2014, 10:23

... the day hospital, you formulated the following therapy goal or theme together with your psychotherapist. Could you work on it? Are you satisfied about how you worked on it (grade 1 to 6)? Do you ... Programme). Author details 1 Institute for Community Medicine University of Greifswald Ellernholzstr. 1/2 17487 Greifswald, Germany. 2 Department of Psychiatry and Psychotherapy University of Gr...

Ngày tải lên: 11/08/2014, 16:23

... determined by the enzymatic balance between synthesis by adenylate cyclase and hydrolysis by phosphodiesterases (PDE). The PDEs represent a large family of isozymes [18], of which PDE4B and PDE4D isotypes ... efficacy in airway disease models of N-(3,5-dichloropyrid-4-yl)-[1-(4- fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic acid amide (AWD 12–281), a selective phosphodiesterase 4 inhibitor...

Ngày tải lên: 12/08/2014, 14:20

... study was to investigate the effect of iNOS deficiency on acute hyperoxic lung injury. As indi- cators of lung hyperpermeability, lavageable lung protein and LDH activity were measured; lung ... lung injury within a few days. Upon hyperoxic exposure, the inducible nitric oxide synthase (iNOS) is activated by a variety of proinflammatory cytokines both in vitro and in vivo. In the pr...

Ngày tải lên: 12/08/2014, 18:21

... strategies aimed at identifying biomarkers of lung cancer are of great interest for early cancer detection. The aim of this study was to set up a new method for identifying and quantifying volatile ... H, Reding D, Riley T, Schwartz M, Spizarny D, Yoffie R, Zylak C: THE LUNG SCREENING STUDY RESEARCH GROUP. Final results of the Lung Screening Study, a randomized feasibility stu...

Ngày tải lên: 12/08/2014, 18:21

... measured by qPCR may be an oncogenic driving force [58]. Increased EGFR gene copy number as determined by fluo- rescent in situ hybridization (FISH) and EGFR protein overexpression measured by immunohistochemistry (IHC) ... were assigned to gefitinb 250 mg/day orally or vinorelbine 30 mg/m2 infusion on days 1 and 8 of a 21-day cycle. With nearly one hundred patients in each study arm, there w...

Ngày tải lên: 10/08/2014, 22:20