Báo cáo y học: "Virtual screening, identification and experimental testing of novel inhibitors of PBEF1/Visfatin/ NMPRTase for glioma therap" doc

... Holliday junction binding and processing by the RuvA protein of Mycoplasma pneumoniae Stuart M. Ingleston 1 , Mark J. Dickman 2 , Jane A. Grasby 3 , David P. Hornby 2 , Gary J. Sharples 4 and ... 269) 1533 and Holliday junction bound by Ec RuvA (Table 1), illustrating the additional stability of the Holliday junc- tion -RuvA complex. The bindin...

Ngày tải lên: 17/03/2014, 17:20

... con- sidered statistically significant. Results Gene expression profile in joints at onset of arthritis To define the gene expression profile at early stages of CIA, we used the murine Affymetrix oligonucleotide ... http://arthritis-research.com/content/7/4/R868 Page 868 of 876 (page number not for citation purposes) Vol 7 No 4 Research article Gene expression profile...

Ngày tải lên: 09/08/2014, 06:23

... response. Identifying the signalling pathways that are involved in inducing the observed alterations in MMP expression may contribute to our understanding of the initiation of kidney damage in lupus nephritis. ... Candidate mediators of such changes include enzymes and signalling substances involved in maintaining the delicate balance between synthesis and breakdow...

Ngày tải lên: 09/08/2014, 13:22

... genes, and the total has steadily grown since then. Currently, the average number of genes listed in the human gene catalogs appears to be somewhere around 22,500, with an uncertainty of around ... uncertainty surrounding their numbers. In recent years, as a result of the dramatic breakthroughs in our understanding of RNA interference [7] and miRNAs [8], the...

Ngày tải lên: 09/08/2014, 20:21

... al.: Virtual screening, identification and experimental testing of novel inhibitors of PBEF1/Visfatin /NMPRTase for glioma therapy. Journal of Clinical Bioinformatics 2011 1:5. Submit your next manuscript ... RESEARCH Open Access Virtual screening, identification and experimental testing of novel inhibitors of PBEF1/Visfatin/ NMPRTase for glio...

Ngày tải lên: 10/08/2014, 09:22

... 277:37487-37491. 8. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE, Tataranni PA: Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. ... (long-term) follow-up. Laboratory analyses For each participant a preoperative fasting blood sample was collected (between 6 a. m. and 11 a. m.) and analyzed at...

Ngày tải lên: 10/08/2014, 09:23

... was 0.135 for the last step. Discussion The main finding of this study is that the prevalence of antipsychotic combination treatment increased with number of hospital admissions, severity of the disease ... more antipsychotics. Conclusions: Previous hospital admissions and disease severity measured by high PANSS scores and low GAF scores, predict...

Ngày tải lên: 11/08/2014, 15:22

... report Open Access Chest wall resection and reconstruction using titanium micromesh covered with Marlex mesh for metastatic follicular thyroid carcinoma: a case report Nobuyasu Suganuma*, Nobuyuki Wada, ... Hiromasa Arai, Hirotaka Nakayama, Keita Fujii, Katsuhiko Masudo, Norio Yukawa, Yasushi Rino, Munetaka Masuda and Toshio Imada Address: Department of S...

Ngày tải lên: 11/08/2014, 17:21

... our PICU is the result of the interpretation of the chest radio- Table 2 Overall concordance of the interpretation of pediatric intensivists (PI) compared to pediatric radiologists (PR) Concordant ... interpretation of chest radiographs by PI and PR in selected clinical situations. These data support the current practice of the PI making therapeuti...

Ngày tải lên: 12/08/2014, 18:20

... 7:73 http://www.retrovirology.com/content/7 /1/ 73 Page 10 of 12 RESEARC H Open Access Mutations in matrix and SP1 repair the packaging specificity of a Human Immunodeficiency Virus Type 1 mutant by reducing the association of Gag with spliced viral ... the packaging of spliced viral RNA in SL1 mutants [11 ,14 ,34,40,45]. Des...

Ngày tải lên: 13/08/2014, 01:20

... for AKI and prolonged mechanical ventilation. Methods This was a case-control study of children undergoing cardiac surgery. AKI was defined as a 50% increase in serum creatinine from baseline ... be early biomarkers of acute kidney injury. In animals, we and others demonstrated that AKI causes lung injury, characterized by neutrophil infiltration and...

Ngày tải lên: 13/08/2014, 16:21

... this article as: Ekelund et al.: Patient throughput times and inflow patterns in Swedish emergency departments. A basis for ANSWER, A National SWedish Emergency Registry. Scandinavian Journal of ... ORIGINAL RESEARCH Open Access Patient throughput times and inflow patterns in Swedish emergency departments. A basis for ANSWER, A Na...

Ngày tải lên: 13/08/2014, 23:20

... consumption in 6.4% (95% confidence interval: 2.0%–10.4%) of adult patients presenting at Emergency Department for chest pain. This finding in chest pain patients who consented to urine analysis suggests ... attention Discussion In USA, with similar cocaine consumption rates to Spain, the Drug Abuse Warning Network DAWN estimates that cocaine was involved in 10% of dr...

Ngày tải lên: 13/08/2014, 23:20

... seen, bovine respira- tory syncytial virus and respiratory syncytial virus are second and third, respectively. Both respiratory syncytial virus and bovine respiratory syncytial virus have higher ... tool for analyzing pathogen-detection microarray datasets that allows simple visualisation, normalisation and significance testing. </p> Abstract DNA microarrays offer the p...

Ngày tải lên: 14/08/2014, 08:20

... 129) using the computer paradigm ImageRate. Food appeal and desire to eat were analyzed for the effects of food group, portion size and energy density of the foods presented as well as by participant characteristics. Results: ... Rolls BJ: The Supersizing of America: Portion Size and the Obesity Epidemic. NutrToday 2003, 38:42-53. 22. Young LR, Nest...

Ngày tải lên: 14/08/2014, 08:20