... proteaseinvolved in the control of vascular permeability. C1-inh isinvolved in the regulation of the complement, contact,coagulation and fibrinolytic systems. It is the main inhibi-tor of C1r ... of the complement system. C1-inh isalso a major inhibitor of factor XII and kallikrein of thecontact system, and to a lesser extent of factor XI and tis-sue-type plasminogen. Finally, C1-inh ... pro-duction of vasoactive peptides, of which bradykinin hasbeen significantly implicated in the development of angioedema [1,2].Clinically, HAE is characterized by acute attacks of painless, non-pitting,...