Báo cáo y học: "Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats" pdf
Báo cáo Y học: Monoterpene biosynthesis in lemon (Citrus limon) cDNA isolation and functional analysis of four monoterpene synthases pot
... 2002 Analysis of lemon monoterpene synthase cDNAs (Eur. J. Biochem. 269) 3161 Monoterpene biosynthesis in lemon (Citrus limon) cDNA isolation and functional analysis of four monoterpene synthases Joost ... (E)-b-ocimene, terpinolene, linalool and a-terpineol. cDNA isolation and sequencingRandom sequencing of a cDNA library made frommRNA isolated from the peel of young lemon fruitsresulted in the identification ... levels of identity of the lemon monoterpene synthases indicate that they should be grouped within thetpsb clade of the angiosperm monoterpene synthases (Fig. 1, and Table 1) [34]. Although the four...
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Báo cáo y học: "Efficacy of treatment with glycosaminoglycans on experimental collagen-induced arthritis in rats" pptx
... Production, School of Veterinary Medicine, University of Messina, Messina, Italy3Department of Experimental and Clinical Medicine and Pharmacology, School of Medicine, University of Messina, Messina, ... activity of the glycosaminoglycans hyaluronic acid (HYA) and chondroitin-4-sulphate (C4S), weused a rat model of collagen-induced arthritis (CIA). Arthritis was induced in Lewis rats by multiple intradermal ... Homologoustype II collagen-induced arthritis in rats. Characterization of the disease and demonstration of clinically distinct forms of arthritis in two strains of rats after immunization with thesame...
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Báo cáo y học: "Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats" pdf
... showsmoderate lung injury. 66.7% of the HS group had moder-ate lung injury and 33.3% had severe lung injury. Treat-ment of rats with MK-886 ameliorates the lung injury significantly as compared w ith induced ... 5-lipoxygenase pathway products meditate acute lung injury following hemorrhagic shock [28,29]. And it hasbeen demonstrated that LTB4 levels were significantlyincreased in the rat lungs following ... [9,38]. Hemorrhagic shock is considered as an insult fre-quently leading to systemic inflammatory response syn-drome including the systemic release of proinflammatorycytokines which is central in t he inflammatory...
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Báo cáo y học: "Macrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous platelets" pdf
... phosphatidyl-serine is not an absolute requirement for phagocytosis ofplatelets.Inflammatory Cytokines are Enhanced Following Platelet PhagocytosisThe hypothesis that macrophage phagocytosis of ... Open AccessMacrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous plateletsChristopher M Scull*, William D Hays, Thomas H FischerAbstractBackground: ... astic tissue-culture plates for TEM analysis andphagocytosis experiments. Media was changed on day 2and day 5, and after 7 days of culture the MDMs wereused for phagocytosis and cytokine assays.PlateletsPlatelets...
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Báo cáo y học: " The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma" pdf
... use the preliminary safety data from t he currentstudy to investigate safety and efficacy over a longerduration, or using other dosing regimens. In summary, we show that the inhaled PDE4 inhibitor GSK256066 ... drugdirectly to the t arget organ to increase therapeuticeffects. GSK256066 (6-({3- [(dimethylamino) carbonyl]phenyl}sulfonyl)-8-methyl -4- { [3-methyloxy)phenyl]amino}-3-quinolinecarboxamide) ... limited by side effects such as gastro-intest-inal symptoms [15-17]. The delivery of a selective a nd potent PDE4 inhibitor by inhalation may improve the therapeutic index by* Correspondence: dsingh@meu.org.uk1The...
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Báo cáo y học: "Potential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infection" pptx
... H Open AccessPotential mechanisms underlying the acute lung dysfunction and bacterial extrapulmonary dissemination during Burkholderia cenocepacia respiratory infectionLuiz G Cunha Jr1, Maria-Cristina ... analysed in both in vitro and in vivo assays.Methods: B. cenocepacia- infected BEAS-2B epithelial respiratory cells were used to investigate the bacterial cytotoxicity assessed by the flow cytometric ... most of the assays. MCA contributed to the design of the study and participated of all flow cytometry assays. GBM participated of allin vivo assays. APDCA, RSL and AMS participated of the molecular...
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Báo cáo y học: "RNA interference for CFTR attenuates lung fluid absorption at birth in rats" doc
... 12(page number not for citation purposes)Respiratory ResearchOpen AccessResearchRNA interference for CFTR attenuates lung fluid absorption at birth in ratsTianbo Li, Shyny Koshy and Hans G Folkesson*Address: ... during early postnatal development. CFTR maintained a relatively high expression at birth andreached adult levels at the 2nd postnatal day. In our earlier study [9], αENaC gene silencing in ... demonstrate by using selectivesiRNA inhibition of CFTR expression that both CFTR andENaC are involved in the transition from lung fluid secre-tion to lung fluid absorption at birth. Our data also...
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Báo cáo y học: "Histone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG mice" docx
... rheumatoid arthritis. Mol Ther 2003, 8:707-717.17. Nishida K, Komiyama T, Miyazawa S, Shen ZN, Furumatsu T, Doi H,Yoshida A, Yamana J, Yamamura M, Ninomiya Y, Inoue H, Asahara H:Histone deacetylase ... 13:R77http:/ /arthritis- research.com/content/13/3/R77Page 4 of 11 RESEARC H ARTIC L E Open AccessHistone deacetylase inhibition alters dendritic cells to assume a tolerogenic phenotype and ameliorates arthritis in SKG miceKenta Misaki1,2, Akio ... changes dendritic cells to a tolerogenic phenotype and ameliorates arthritis in SKG mice.IntroductionRheumatoid arthritis is a chronic inflammatory disorder,charac terized by cellula r infi ltr ation...
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Báo cáo y học: "Green tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy in mice" ppt
... [26]. In this study we investigated the role of Green tea extract in rodent model carrageenan-induced pleurisy. This experimental model has been widely used to investi-gate the pathophysiology of ... 1 of 13(page number not for citation purposes)Respiratory ResearchOpen AccessResearchGreen tea polyphenol extract attenuates lung injury in experimental model of carrageenan-induced pleurisy ... infiltrationlung injury AbstractHere we investigate the effects of the green tea extract in an animal model of acute inflammation, carrageenan-induced pleurisy. We report here that green tea extract...
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Báo cáo y học: "Clinical risk conditions for acute lung injury in the intensive care unit and hospital ward: a prospective observational study" potx
... respiratory distress syndrome (ARDS) isan inflammatory lung injury involving both endothelial and epi-thelial layers of the alveolar-capillary membrane, with subse-quent alveolar flooding and formation ... 10(page number not for citation purposes)Vol 11 No 5ResearchClinical risk conditions for acute lung injury in the intensive care unit and hospital ward: a prospective observational studyNiallDFerguson1, ... OP, AA, GG, AA, and IR participated in the acquisi-tion of the data. NDF performed the data analysis and wrote the first draft of the manuscript, which was then revised for intellectually important...
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Báo cáo y học: " Albumin and furosemide for acute lung injury" doc
... critically ill patients, associated with the development of acute lung injury and acute respiratory distress syndrome and subsequent worse clinical outcomes. Albumin with furosemide benefits lung ... independent pharmacologic effects of albumin and furosemide in hypoproteinemic patients with acute lung injury /acute respiratory distress syndrome. Design: Randomized, double-blinded, placebo-controlled ... surgical, and trauma intensive care units including 190 beds within two university hospital systems. Subjects: Forty mechanically ventilated patients with acute lung injury /acute respiratory distress...
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Báo cáo y học: "The histopathology of septic acute kidney injury: a systematic review" ppt
... review of the histopathological features of septic AKIhas yet been performed.Accordingly, we systematically evaluated all available humanand experimental studies describing kidney histopathology ... biopsy specimens. Nonetheless, the paucity of data on the histology of septic AKI in humans naturally led usTable 2Primate studiesStudy Cause Cases of acute kidney injury/number of animals ... forearly acute kidney injury in a cohort of Australian intensivecare units. Crit Care 2007, 11:R68.3. Bagshaw SM, George C, Bellomo R: Early acute kidney injuryand sepsis: a multicentre evaluation....
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Báo cáo y học: "Activated protein C ameliorates coagulopathy but does not influence outcome in lethal H1N1 influenza: a controlled laboratory study" potx
... Activated protein C ameliorates coagul-opathy but does not influence outcome in lethal H1N1 influenza: a con-trolled laboratory study Critical Care 2010, 14:R65 Schouten et al. Critical Care 2010, ... the influenza-induced rise in plasma and lung PAI-1 levels and partially preservingplasma and lung fibrinolytic activity. The capacity of APCto attenuate systemic coagulation during severe bacterialinfection ... on coagulation acti-vation during severe bacterial infection, data on coagula-tion activation in viral infection like influenza are sparse.Evidence that influenza can be associated with coagula-tion...
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Báo cáo y học: "Invasive pulmonary and central nervous system aspergillosis following slops aspiration in a trauma patient" pot
... died 40 days after injury.We have described invasive aspergillosis with a rapidly progressive and fatal pulmonary and cerebral course in a previously healthy man. Neuroaspergillosis is an uncommon ... this invasive pulmonary aspergillosis was then further complicated by dissemination to the CNS on day19. In conclusion, we report a rare trauma case accom-panied with invasive pulmonary and ... fall and aspiration of slops. In view of aspiration pneumonitis (Figure 1, day 1), intravenous antibiotic treat ment (tazocin, moxifl oxacin hydrochloride and metroni da zole) was started. Brain...
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Báo cáo y học: "A computational method to predict genetically encoded rare amino acids in proteins" pdf
... to incorporate two additional amino acids with distinct functionality, selenocysteine and pyrrolysine. These rare amino acids canbe overlooked inadvertently, however, as they arise by recoding ... read-throughcases.Putative pyrrolysine recoding in archaeaThe RSA method was also used to search for proteins poten-tially containing the pyrrolysine residue, the so-called 22nd amino acid (Table 2). The pyrrolysine ... genetically encoded rare amino acids (RAAs) are selenocysteine and pyrrolysine,the proposed 21st and the 22nd amino acids, respectively [3-7].Selenocysteine, a selenium-analog of cysteine, is a potentnucleophile...
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