... J Autoimmun 1997, 10:251-256.28. Yamamura M, Kawashima M, Taniai M, Yamauchi H, Tanimoto T,Kurimoto M, Morita Y, Ohmoto Y, Makino H: Interferon-gamma-inducing activity of interleukin-18 in ... K, Tagawa Y, Iwakura Y, KayagakiN, Kurimoto M, Okamura H, Hada T, Yagita H, Akira S, NakanishiK, Higashino K: IL-18 up-regulates perforin-mediated NK activ-ity without increasing perforin messenger ... macrophages wasobserved only within periductal inflammatory foci and in periacinar macrophages adjacent to focal infiltrates, andnot in isolated macrophages, an observation that suggestsan activation...