Báo cáo y học: "Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient to restore circadian food anticipatory rhythms in Bmal1-/- mice" pot

... supported by the recent findings of McCarty et al, who showed an effect of anagrelide on CD41 numbers and TPO-specific pTyr activity in vitro, indicating that anagrelide reduces the TPO-mediated intracellular ... Lacey D, Hill D, Chen Y, Fletcher F, Hawley RG, McNiece IK A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligan...

Ngày tải lên: 03/11/2012, 10:52

... enzymes, decreasing the activities of arylsulfatase A and arysulfatase B, an N-acetyl- galactosaminidase-4-sulfatase, but increasing the activity of acid phosphatase in normal and OA chondrocytes ... further research is needed to evalu- ate the safety and potential benefits of cetyl myristoleate and cetylated fatty acids in the treatment of OA. Vitamins and miner...

Ngày tải lên: 09/08/2014, 08:22

... for citation purposes) Vol 9 No 2 Research article Vaccination response to tetanus toxoid and 23-valent pneumococcal vaccines following administration of a single dose of abatacept: a randomized, ... tet- anus toxoid and 23-valent pneumococcal vaccines. Serum samples were obtained for subjects of Groups A and B at study days 14 and 28, f...

Ngày tải lên: 09/08/2014, 10:20

... amyloid and advanced glycation end products (AGEs) [15]. AGEs are the products of nonenzymatic glycation and oxidation of proteins that form with aging, diabetes and renal failure, and at sites of inflammation ... Goodson and colleagues recently demonstrated 10% mortality, predominantly owing to CV events, within 10 years of onset of inflammatory polyarthri- t...

Ngày tải lên: 09/08/2014, 10:20

... or induce these inflammatory mediators. Accordingly, the present study examines the interplay between mechano-sensitive and cytokine-sensitive pathways, and determines the effects of IL-1β and ... or dynamic compression. In addition to the regulation of iNOS and COX-2 expression by dynamic compression, co- stimulation with the inhibitor was important in restoring the cytokin...

Ngày tải lên: 09/08/2014, 10:23

... 12:R65 http://genomebiology.com/2011/12/7/R65 Page 3 of 17 RESEARC H Open Access Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins Johan Nilsson 1 , ... (39 genes), again sug- gesting a positive correlation between intrinsic disorder and degree of positive selection within proteins. Intrinsicall...

Ngày tải lên: 09/08/2014, 23:20

... purposes) Journal of Circadian Rhythms Open Access Review Standards of evidence in chronobiology: critical review of a report that restoration of Bmal1 expression in the dorsomedial hypothalamus is sufficient ... published by the same laboratory, appear to establish the DMH as the site of a Bmal1- dependent circadian mechanism nec...

Ngày tải lên: 10/08/2014, 09:20

... remain awake and active, engaging in wheel-running and increased drinking of further MA, and further wheelrunning, until the animals are exhausted and sleep (at which point they stop drinking MA ... the last paragraph of our paper is: " ;In an intact animal, peripheral oscillators in many tissues in the body, including the stomach and the liver, as well as elsewhere in the br...

Ngày tải lên: 10/08/2014, 09:20

... original work is properly cited. Research "If you don't believe it, it won't help you& quot;: use of bush medicine in treating cancer among Aboriginal people in Western Australia Shaouli ... " Secrecy and mystery abound in the Aboriginal commu- nity about the use and availability of bush medicine. This inevitably means poor av...

Ngày tải lên: 10/08/2014, 09:21

... management of bipolar disorder. In 2009, 38 mental health Trusts in the UK participated in a baseline audit of the quality of lithium monitoring as part of a quality improvement program (QIP) run by the Prescribing ... contributed to the methodology of the study, interpretation of the data and drafting the paper. CP: contributed to the literature se...

Ngày tải lên: 11/08/2014, 16:22

... al.: Genital herpes evaluation by quantitative TaqMan PCR: correlating single detection and quantity of HSV-2 DNA in cervicovaginal lavage fluids with cross-sectional and longitudinal clinical ... 7:328 http://www.virologyj.com/content/7/1/328 Page 3 of 8 RESEARC H Open Access Genital herpes evaluation by quantitative TaqMan PCR:...

Ngày tải lên: 12/08/2014, 02:20

... al., First serological evidence of West Nile virus in human rural populations of Gabon Virology Journal 2010, 7:132 Pourrut et al. Virology Journal 2010, 7:132 http://www.virologyj.com/content/7/1/132 Open ... transmission patterns in Gabon. Findings West Nile virus (WNV) is a mosquito-borne RNA virus belonging to the genus Flavivirus, family Flaviviridae....

Ngày tải lên: 12/08/2014, 04:20

... between multi-symptom asthma and different symptoms of allergic and chronic rhinosinusitis. Methods: This study analyzed data on asthma symptoms, rhinitis, and chronic rhinosinusitis from the 2008 West Sweden ... bacteria and fungi, could interfere with both nasal symptoms and the severity of asthma [13]. In addition to the number of nasal s...

Ngày tải lên: 12/08/2014, 11:23

... purposes) Poly(I:C) induces a dose dependent influx of inflammatory cells into the airways of miceFigure 1 Poly(I:C) induces a dose dependent influx of inflammatory cells into the airways of mice. ... comparisons. Results Poly(I:C) induces a marked inflammatory response in the lungs of mice Intranasal administration of three once-daily doses of poly(I:C) resulted in a dose-...

Ngày tải lên: 12/08/2014, 14:20

... for citation purposes) Retrovirology Open Access Research No genetic evidence for involvement of Deltaretroviruses in adult patients with precursor and mature T-cell neoplasms Thomas Burmeister* 1 , ... T-cell (50) Early T-cell lymphoblastic 11 Cortical (thymic) T-cell lymphoblastic 31 34 (17–63) Mature T-cell lymphoblastic 8 Mature T-cell (31) T...

Ngày tải lên: 13/08/2014, 09:20