Atlas of Clinical Hematology - part 5 pdf

... Dr. Witte of Erlangen, Dr. Langreder of Mainz, Prof. Dr. Mohr of the Tropical Institute of Hamburg, Dr. Moeschlin of Zurich, Dr. Undritz of Basel, and Dr. Kuhn of our Freiburg Clinic. We also thank ... We also thank the Institute of Pathology of the University of Kiel, headed by Prof. Karl Len- nert, and the current head of the Department of Hematologic Pathology, Prof...

Ngày tải lên: 05/03/2014, 11:21

... effect of the drugs, it may produce severe agonist–mediated effects (such as hypertension or tachycardia) if the blocking drug is abruptly withdrawn. Chapter 005. Principles of Clinical Pharmacology ... site of action, it alters the function of that molecular target, with the ultimate result of a drug effect that the patient or physician can perceive. For drugs use...

Ngày tải lên: 06/07/2014, 08:20

... Response Chapter 005. Principles of Clinical Pharmacology (Part 6) Principles of Dose Selection The desired goal of therapy with any drug is to maximize the likelihood of a beneficial ... an understanding of the relationships between plasma concentration and anticipated effects. For example, measurement of QT interval is used during treatment with sotalo...

Ngày tải lên: 06/07/2014, 08:20

... Chapter 105. Malignancies of Lymphoid Cells (Part 5) Table 105- 5 Diseases or Exposures Associated with Increased Risk of Development of Malignant Lymphoma Inherited ... activation of a series of transcription factors, the cell first becomes committed to the lymphoid lineage and then gives rise to B and T cells. About 75% of all lymphoid leukemias and 9...

Ngày tải lên: 07/07/2014, 04:20

... permeability and cause active drug efflux from the cytoplasm. Mutations that result in active quinolone efflux are also found in gram-positive bacteria. Chapter 127. Treatment and Prophylaxis of Bacterial ... dihydrofolate reductase for trimethoprim and an altered dihydropteroate synthetase for sulfonamides. Quinolones The most common mechanism of resistance to qu...

Ngày tải lên: 08/07/2014, 02:20

... Reaction) 11 1. 11 Sudan Black B Stain 13 1. 12 Cytochemical Determination of Peroxidase 13 1. 13 Hydrolases 13 1. 13 .1 Cytochemical Determination of Leukocyte Alkaline Phosphatase (LAP) in Blood Smears 13 1. 13.2 ... Causative Organisms of Tropical Disease 399 II Table 2. Cytochemistry of blood and bone marrow cells Per- oxidase PAS Esterase a-Naphthyl- acetate-, Naphth...

Ngày tải lên: 10/08/2014, 08:20

... pro- ceeding with a more detailed evaluation. Figure 22 f, g shows the appearance of a normal bone marrow smear viewed at high magnifica- tion. Figure 22 a, b illustrates the range of varia- tion ... (histologic sec- tions). Figure 22 c shows how the naphthol AS-D chloroacetate esterase method can be used to lo- calize early neutrophilic granulocytop oiesis close to bony trabeculae. Fi...

Ngày tải lên: 10/08/2014, 08:20

... Marrow IV Fig. 35 a –d. Effect of hematopoietic growth factors a Peripheral blood smear after the ad- ministration of G-CSF b Left shift following G-CSF c Maximum leukocyte alkaline phos- phatase ... following G-CSF d Bone marrow following chemotherapy and the administration of G-CSF de- monstrates promyelocytes and myelo- cytes, some showing mild atypia 1 13 5 · Bone Marrow IV Fig....

Ngày tải lên: 10/08/2014, 08:20

... and paucity of fat cells d Histologic section during chronic phase of CML. Naphthol AS-D chloro- acetate esterase reaction shows an ex- treme increase in neutrophilic granulo- cytopoiesis 148 Chapter ... BCR-ABL translocation, the demonstra- tion of low or even negative leukocyte alkaline phosphatase (LAP, see p. 13) w as of key impor- tance. Today the diagnosis is established by det...

Ngày tải lên: 10/08/2014, 08:20

... ne- cessary for an accurate classification 189 5 · Bone Marrow IV Fig. 66 i Partial karyotype of a dicentric chromosome 5; 17 that leads to a simultaneous loss of the long arm of chromosome 5 ... the short arm of chromosome 17. The loss of the short arm of chromosome 17 (17p-) causes the loss of an allele of p53, which is localized there in the band 17p13. Structural cha...

Ngày tải lên: 10/08/2014, 08:20

... cyto- plasm and, above the nucleus, a signal (blue-green dot at lower right) from the normal chromosome 16 and a two -part signal (two groups of small dots at left) from the inverted chromosome 16. ... Variants of the M4 sub- type a Severely dysplastic erythropoiesis. At center are three erythroblasts, two of which are very immature forms. The cy- toplasm of the upper erythroblast i...

Ngày tải lên: 10/08/2014, 08:20

... subtype of ALL violates the dogma that cytoplas- mic granules are suggestive of AML. This case is a B-lineage type of ALL with cytoplasmic granules that are peroxi- dase-negative and behave as lyso- somes a ... isolated Lan- ghans giant cells Fig. 138 a, b), and toxoplasmosis (epitheloid-cell lymphadenitis of Piringer-Ku- chinka, see Fig. 136 a – d). In the examination of cervical l...

Ngày tải lên: 10/08/2014, 08:20

... koăn- nen B- und T-Zell-Lymphome unterschieden wer- den. B-Zell-Lymphome sind in Europa und Ame- rika haăufiger, waăhrend die T-Zell-Lymphome in Asien uăberwiegen. Unter Einbeziehung von mor- phologischen ... Immunphaănotyp oder gene- tisch-molekulargenetisches Profil nicht moăglich. B-, T- und NK-Zell-Neoplasien werden weiter in Vorstufen-(Precursor) und reife (mature) Er- krankungen unterte...

Ngày tải lên: 10/08/2014, 08:20

... is sig- nificant lymphadenitis with clinical manifesta- tions such as headache, low-grade fever, and sin- gle or multiple lymph node enlargement, particu- larly in the neck. Involvement of the ... the rest of the patient’s life, sig- nifying that the infection has entered its latent stage. Recently, the so-called test of avidity proved to be of help in calculating the duration of...

Ngày tải lên: 10/08/2014, 08:20

... 10 .5 Frequency of cystic fibrosis mutations screened in the North-West of England Mutation Frequency (%) G85E 0.3 R117H 0.7 621 ϩ 1G→T 1.0 1078delT 0.1 ⌬I507 0 .5 ⌬F508 88.0 171 7-1 G→T 0.3 G542X ... haematuria Renal failure acg-10 11/20/01 7:27 PM Page 53 ABC of Clinical Genetics 52 Hypertrophic cardiomyopathy (HOCM) has an incidence of about 1 in 1000. Presentation i...

Ngày tải lên: 10/08/2014, 14:22