Báo cáo y học: "Characteristics of HIV-infected women and factors associated with HCV seropositivity in the Republic of Georgia" doc

Báo cáo Y học: RING ﬁnger, B-box, and coiled-coil (RBCC) protein expression in branchial epithelial cells of Japanese eel, Anguilla japonica pot

... that yielded similar results.Ó FEBS 2002 RBCC protein expression in Anguilla japonica (Eur. J. Biochem. 269) 6155 RING ﬁnger, B-box, and coiled-coil (RBCC) protein expression in branchial epithelial ... B-box, and coiled-coil (RBCC) proteins are agroup of zinc-binding proteins that belong to the RING ﬁnger family. They are so called because they have anN-terminal RING ﬁnger motif deﬁned by one ... activity, suggesting an importantregulatory role of eRBCC in the remodeling of branchial cells. Keywords: freshwater adaptation; gill; RBCC protein; RING ﬁnger; ubiquitin ligase. RING ﬁnger, B-box,...

Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt

... Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku- 80 subunit is necessary for basal transcription of the WD gene Won ... Immunoblot analysis and EMSAs showed that the MREa-binding proteins are immunologically rela-ted to the Ku proteins. To study further the functionalsigniﬁcance of these Ku- related proteins in transcriptionalregulation ... using syntheticMREa and an oligonucleotide containing the binding site for transcription factor Sp1 revealed the presence of nuclear factors that bind speciﬁcally to MREa. Two MREa-bindingproteins...

Báo cáo y học: " Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune disease" pot

... cell surface early after theReview Multiple functions for CD28 and cytotoxic T lymphocyte antigen-4 during different phases of T cell responses: implications for arthritis and autoimmune diseasesMonika ... but also by theintegration of the absence of positive costimulatory signals and the presence of negative costimulatory signals. CD28 and cytotoxic T lymphocyte antigen-4 (CTLA-4; CD152),two ... body of evidence that, in concert with the T cell antigenreceptor signal, CD28 and cytotoxic T- lymphocyte antigen-4 (CTLA-4; CD152) are the primaryregulators of T cell responses. Whereas CD28...

Báo cáo y học: " TGF β-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7" pps

... the synovial lining is where TGF- β induces synovial fibrosis, by co-transfection with Smad7, the lining appeared tobe less sensitive to TGF- β-induced fibrosis. The reduction of TGF- β-induced fibrosis ... deal of the TGF- β-induced synovial fibrosis. Combining Smad7 and TGF- β resulted in a higher PG synthesis after IL-1 insult thandid TGF- β alone. This is likely due to the reduced synovial fibrosis ... every single one of the synoviallining cells and thereby fully block the TGF- β-induced fibrosis. We have previously demonstrated that blocking TGF- β withAd-Smad7 in OA resulted in reduction of...

Báo cáo y học: "Interactions between IL-32 and tumor necrosis factor alpha contribute to the exacerbation of immune-inflammatory diseases" ppt

... 4 Exacerbation of murine models of tumor necrosis factor alpha- related inflammatory diseases in BM-hIL-32 miceExacerbation of murine models of tumor necrosis factor alpha- related inflammatory diseases ... complementary to the uniquesequence of hIL-32β, because IL-32 is the dominant secret-ing isoform of IL-32. This probe could detect the cDNA of hIL-32β and IL-32 , but not of IL-32 or IL-32 , by Southernhybridization ... cells in vivo, and the in vivoroles of IL-32 were mainly to induce other inflammatorycytokines rather than to activate the proliferation of the immunecells. In the present study, we also demonstrated...

Báo cáo y học: " High sensitivity C-reactive protein is associated with lower tibial cartilage volume but not lower patella cartilage volume in healthy women at mid-life" pdf

... article High sensitivity C-reactive protein is associated with lower tibial cartilage volume but not lower patella cartilage volume in healthy women at mid-lifeFahad S Hanna1,2,3,4*, Robin J ... variation in patella cartilage volume. Conclusion In asymptomatic women aged 40 to 67 years,serum hsCRP is independently negatively associated with the volume of tibial but not patella cartilage ... MK: Elevated high- sensitivity C-reac-tive protein levels are associated with local inflammatoryfindings in patients with osteoarthritis. Osteoarthritis Cartilage 2007, 15:516-523.24. Matsumoto...

Báo cáo y học: "Reduced proportions of natural killer T cells are present in the relatives of lupus patients and are associated with autoimmunity" ppt

... correlation between the proportion of total NKT cells and disease activity or drug therapy in our lupus patients, which suggests that the reduction in NKT cells in these patients does not arise ... cytokinesthat are secreted by the NKT cells in the different lupus mousemodels, with interleukin-4-secreting NKT cells inhibiting lupus and interferon-γ-secreting NKT cells exacerbating lupus [53,54,56,57]. ... herita-ble trait. These findings raise the possibility that one of the explanations for the clustering of multiple autoimmune disor-ders within the families of lupus patients is the presence of genetic...

Báo cáo y học: "Characteristics of HIV-infected women and factors associated with HCV seropositivity in the Republic of Georgia" doc

... Tsertsvadze1,4AbstractBackground: The aim of this study was to describe the extent of the HIV epidemic among women in the Republic of Georgia and to identify factors associated with HCV co-infection in this population.Findings: ... Characteristics of HIV-infected women and factors associated with HCV seropositivity in the Republic of Georgia. AIDS Research and Therapy 2011 8:25.Submit your next manuscript to BioMed Central and take ... closely tied to the IDU community. Evidence-basedinterventions targeting IDU and partners of IDU are urgently required to halt the spread of the HIV epidemic in the country.FindingsTheNewlyIndependentStates(NIS)ofEurasiahavethehighest...

Báo cáo y học: "Mitral valve surgery for mitral regurgitation caused by Libman-Sacks endocarditis: a report of four cases and a systematic review of the literature" pptx

... surgery for mitral regurgitation caused by Libman-Sacks endocarditis: a report of four cases and a systematic review of the literature. Journal of Cardiothoracic Surgery 2010 5:13.Submit your ... regurgitation and/ or stenosis requiring surgery. In this study we report two cases of mitral valve repair and two cases of mitral valve replacement for mitral regurgitation (MR) caused by Libman-Sacks ... persists mitral valve surgery may be required. Valve repair versus replacement and valve selectionIn contemporary cardiac surgery mitral valve repair hasbecome the mainstay of surgical treatment for...

Báo cáo y học: " Part I, Patient perspective: activating patients to engage their providers in the use of evidencebased medicine: a qualitative evaluation of the VA Project to Implement Diuretics (VAPID)" ppsx

... value to clinical administration leaderswho are responsible for improving the quality of care. The patient activation strategy was acceptable to most patients, served as a to ol to engage patients ... appear to be systematic.Summary The primary purpose of this study was to evaluate the acceptability of a patient- activated intervention from the patients perspective. Patients along a spectrum of ... to engage their providers in the use of evidence-based medicine: a qualitative evaluation of the VA Project to Implement Diuretics (VAPID)Stacey A Pilling1, Monica B Williams1, Rachel Horner Brackett1,...

Báo cáo y học: "B-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by atacicept and B-cell maturation antigen-immunoglobulin" pdf

... of 14 RESEARC H ARTIC L E Open AccessB-lymphocyte stimulator/a proliferation-inducing ligand heterotrimers are elevated in the sera of patients with autoimmune disease and are neutralized by ... shown). The inhibition of BLyS, APRIL, and the heterotrimers by atacicept is consistent with the observed effects of atacicept and/ or murine TACI-Ig in preclinical and clin-ical studies. In mice and ... from patients with SLE and RAused in this study, levels of BLyS, APRIL, and heterotri-mer were elevated in patients with SLE, compared with the sera of healthy donors. The detection of a singleligand...

Báo cáo y học: "Pro/con clinical debate: Is high-frequency oscillatory ventilation useful in the management of adult patients with respiratory failure" ppt

... high-frequency oscillatory ventilation (HFOV) hasbecome an increasingly common therapy. This may not have been the case if researchers had notpersisted in investigating the therapy after early disappointing ... compelling arguments for and against the use of HFOV at thispoint in adults.Keywords acute respiratory failure, critical illness, high-frequency oscillatory ventilation, mechanical ventilation The ... scenarioPro: Yes, HFOV is useful in the management of adult patients with respiratory failureJeffrey M Singh and Sangeeta MehtaConventional mechanical ventilation (CMV) may contribute tolung injury through...

Báo cáo y học: "Association between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injury" docx

... The aim of the present study was to identify, within a panel of inflammatory mediators released during endotoxin-induced lung injury, specific mediators that are associated with a PaO2 response ... http://ccforum.com/content/12/5/R131Page 1 of 8(page number not for citation purposes)Vol 12 No 5ResearchAssociation between inflammatory mediators and response to inhaled nitric oxide in a model of endotoxin-induced lung injurySebastien ... degree of pulmonary damage separating responders fromnonresponders may be an explanation for the varyingresponses to INO. Besides, a limitation may include the intra-variability and intervariability...

Báo cáo y học: "Mechanical ventilation using non-injurious ventilation settings causes lung injury in the absence of pre-existing lung injury in healthy mice" pdf

... and the contribution of MV to lung injury in the absence of pre-existing lung injury. IntroductionMechanical ventilation (MV) may aggravate pre-existing lung injury or even cause lung injury in ... behind VILI and the contribution of MV to lung injury in the absence of pre-existing lung injury. Competing interests The authors declare that they have no competing interests.Figure 5Thrombin-antithrombin ... and/orbacteria into the circulation. MV in combination with prolongedexposure to hyperoxia (> 95% of oxygen) augmented lung injury [24]. However, lung injury caused by 50% of oxygen, asused in our...

Báo cáo y học: "Genomic neighborhoods for Arabidopsis retrotransposons: a role for targeted integration in the distribution of the Metaviridae" docx

... the primarydeterminant of element abundance in A. thaliana. Wright etal. [33] examined recombination rate relative to elementabundance in detail and found that the abundance of most A. thaliana ... heterochro-matin. The square root of age was used as the responsevariable in the age analysis so that the variance of the response would be roughly constant across categories definedby combinations of ... spreadsheet of datagenerated by RetroMap for each retrotransposon insertionidentified; the data in this file was used for all statisticalanalyses (Additional data file 1). The Java application...

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