Báo cáo y học: "Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis in HIV" potx
Báo cáo y học: "Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis in HIV" potx
... [http://clinicaltrials.gov/ct2/ show/NCT00811954?term=ACTG+5257&rank=3]. doi:10.1186/1742-6405-8-14 Cite this article as: Chu et al.: Drug efficacy by direct and adjusted indirect comparison to placebo: An illustration by Mycobacterium avium complex prophylaxis ... primary endpoints. Table 2 Efficacy of MAC regimens by direct and adjusted indirec...
Ngày tải lên: 10/08/2014, 05:22
Báo cáo Y học: Domain V of m-calpain shows the potential to form an oblique-orientated a-helix, which may modulate the enzyme’s activity via interactions with anionic lipid potx
... divided into domains I to IV and the smaller subunit divided into domains V and VI. Domain II possesses the active site and is a papain-like cysteine protease domain, and domain IV contains a calmodulin-like ... daphoenix@uclan.ac.uk Abbreviations:Myr 2 PtdCho, dimyristoylphosphatidylcholine; Myr 2 PtdEtn, dimyristoylphosphatidylethanolamine; Myr 2 PtdSer, dimyristoylphosphatidylser...
Ngày tải lên: 17/03/2014, 10:20
Báo cáo y học: "Broad-range PCR, cloning and sequencing of the full 16S rRNA gene for detection of bacterial DNA in synovial fluid samples of Tunisian" pps
... data analyses. BJ and JS participated in the design and coordination of the study, and drafted the manuscript. MR has assisted in writing the manuscript. AH and AS analyzed microbiological and sequencing ... coordination of the study, analyzed the data, and revised the manuscript. HF, MY, SB, NB, and SS made pathological diagnosis, conducted sampling procedures, and perfor...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: "Physical function, disease activity, and health-related quality-of-life outcomes after 3 years of adalimumab treatment in patients with ankylosing spondylitis" potx
... pain, fatigue, and stiffness in patients with ankylosing spondylitis: results from the Adalimumab Trial Evaluating Long-Term Safety and Efficacy for Ankylosing Spondylitis (ATLAS). J Rheumatol ... Visvanathan S, Sieper J, Braun J: Safety and efficacy of readministration of infliximab after longterm continuous therapy and withdrawal in patients with ankylosing spondylitis. J Rh...
Ngày tải lên: 09/08/2014, 14:22
Báo cáo y học: "omparative Efficacy and Tolerability of 5-Loxin® and Aflapin® Against Osteoarthritis of the Knee: A Double Blind, Randomized, Placebo Controlled Clinical Study"
... 5-Loxin ® and Aflapin ® . TG contri- buted as the study coordinator and helped to review the manuscript. KVSS and DD helped in clinical data analysis. SMR helped in designing and executing ... compared to 5-Loxin, Aflapin is capable of inhibiting cartilage degrading enzyme MMP-3 and has the po- tential to regulate the inflammatory component in by inhibiting ICAM-...
Ngày tải lên: 25/10/2012, 11:40
Báo cáo Y học: The role of the second binding loop of the cysteine protease inhibitor, cystatin A (stefin A), in stabilizing complexes with target proteases is exerted predominantly by Leu73 pdf
... kDa. The single polypeptide chain of a kininogen contains three domains resembling family 2 cystatins. Cystatins competitively inhibit the activity of papain- like cysteine proteases by binding to the ... kinetics Association rate constants, k ass, for the inhibition of papain and cathepsins L and B by the cystatin A mutants were determined by continuously monitoring the loss of e...
Ngày tải lên: 17/03/2014, 10:20
Báo cáo Y học: Functional analysis of the rat bile salt export pump gene promoter Regulation by bile acids, drugs and endogenous compounds potx
... specific antibody against the nuclear receptor FXR (lanes 3 and 4), or against retinoid X receptor (RXR) (lanes 5 and 6) or a combination of both (lanes 7 and 8) resulted in a reduction of signal intensities ... library (Genome Systems) by PCR. Each strand of the 5¢ flanking region of the Bsep gene was directly sequenced (Epidauros, Bernried, Germany) by automated sequencing. The se...
Ngày tải lên: 17/03/2014, 23:20
Báo cáo Y học: Shifted positioning of the anticodon nucleotide residues of amber suppressor tRNA species by Escherichia coli arginyl-tRNA synthetase pdf
... The arginine-accepting activity of FTOR1 is higher than that of FTOR1D26 in vitro (Table 1). However, FTOR1 inserts Lys and Tyr, in addition to Arg, but FTOR1D26 predominantly inserts Arg, in response ... lysine- and tyrosine-accepting activities, of the tRNA was increased, and (b) the recognitions of the tRNA by LysRS and TyrRS were more impaired than that by ArgRS. The p...
Ngày tải lên: 31/03/2014, 23:20
Báo cáo y học: "Commentary on “Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus”, by RR Graham et al" pdf
... haplotypes at chromosome 1q41 in human systemic lupus erythematosus”, by RR Graham et al. Anne C Barton and Jane Worthington Arthritis and Rheumatism Campaign Epidemiology Unit, University of Manchester, ... may seem disappointing. As for most common diseases, susceptibility to autoimmunity is thought to be determined by both genetic and environ- mental factors. These autoimm...
Ngày tải lên: 09/08/2014, 03:24
Báo cáo y học: "Tumor necrosis factor alpha and epidermal growth factor act additively to inhibit matrix gene expression by chondrocyte" pptx
... involved in regulating the aggrecan and type II collagen genes and in remodeling of the cytoskeleton in response to factors present during inflammation. The MAPK/ERK pathway plays an important role in ... promotes further expression of cytokines and chemokines by synovial cells and chondro- cytes, thereby sustaining a renewal of local inflammatory mediators (reviewed in...
Ngày tải lên: 09/08/2014, 06:22