... that the active components of the EA extract of TwHF inhibited the initiation of antibody responses but not ongoing antibody production by established plasma cells. Notably, treatment of RA patients ... varying locations. As the composition of these preparations was uncertain, the treatment dose of the extract was determined according to the weight of the raw pla...
Ngày tải lên: 09/08/2014, 07:20
... 7a–c; Table 1). The concentration of proteogly- cans from the middle of the tissue, beyond the penetration of the mAb, did not differ from the controls, as judged by the height of the peaks at 1175-960 ... successful treatment of inflammation can still leave an ongoing problem of continuing joint destruction [40-42]. In the present study, the effect of the...
Ngày tải lên: 09/08/2014, 06:23
Báo cáo y học: "The impact of the National HIV Health Care Worker Hotline on patient care in South Africa" docx
... counselling, further investigations, referring or admission of patients. Conclusions: The information provided by the National HIV HCW Hotline on patient- specific requests has a direct impact on the ... ques- tions were contacted on the same day for a question- naire-based interview on how they used the information. For the duration of the study, the drug...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo y học: "Anticancer Activity of the PR Domain of Tumor Suppressor RIZ1"
... Liu L. The PR domain of the Rb-binding zinc finger protein RIZ1 is a protein binding interface and is related to the SET domain functioning in chromatin-mediated gene expression. J Biol Chem ... [15, 18]. Most of them are located near the N-terminal portion of the proteins followed by zinc-fingers, and are involved in the reg- ulation of cell division and differen...
Ngày tải lên: 25/10/2012, 11:15
Báo cáo y học: " Experimental ablation of the pancreas with high intensity focused ultrasound (HIFU) in a porcine model"
... and bulky. A narrow region w i t h inflammatory cell infiltration, consisting primarily of lymphocytes and monocytes sometimes with small number of eosinocytes, were seen between the necrotic ... efficacy and safety. To evaluate the rela- tionship between HIFU energy and pancreas histol- ogy, a preclinical in vivo study was conducted in swine demons t rat ing the feasibilit...
Ngày tải lên: 25/10/2012, 11:18
Tài liệu Báo cáo Y học: Molecular modeling of the dimeric structure of human lipoprotein lipase and functional studies of the carboxyl-terminal domain docx
... support of this hypo- thesis are meager. In the head-to-tail orientation, the catalytic site in the N-terminal domain of one subunit and the substrate recognition site in the C-terminal domain of the ... (Arg405, Lys407, Lys413, Lys414, Lys422, Lys428, and Lys430) oriented in the same direction with the heparin-binding domain at the N-terminal end [14]. The o...
Ngày tải lên: 21/02/2014, 15:20
Tài liệu Báo cáo Y học: Structural determinants of the half-life and cleavage site preference in the autolytic inactivation of chymotrypsin pdf
... sites of chymotrypsin. D-Chymotrypsinogen is a chimera constructed to contain a trypsinogen propeptide instead of the Cys1–Cys122-linked wild-type chymotryp- sinogen peptide. D-Chymotrypsinogen ... 2). Finally it is of interest regarding the in vivo mechanism of inactivation, that chymotrypsin and trypsin, mixed in concentration ratios close to those in the intestines, did...
Ngày tải lên: 22/02/2014, 07:20
Tài liệu Báo cáo Y học: Solution structure of the mEGF/TGFa44250 chimeric growth factor doc
... measured in the first instance. Constraint violations were examined using the program DYANA. Superposition of the family of structures, calculation of the rmsd of atomic coordinates, and preparation of ... with binding resulting in receptor dimerization, activation of the intrinsic receptor tyrosine kinase, and initiation of intracellular signal transduction [14]. A...
Ngày tải lên: 22/02/2014, 07:20
Tài liệu Báo cáo Y học: EPR characterization of the mononuclear Cu-containing Aspergillus japonicus quercetin 2,3-dioxygenase reveals dramatic changes upon anaerobic binding of substrates potx
... coordinates the metal only in its minor conformation. In its principal conformation the carboxylate side chain of Glu73 points away from the metal centre. Though precise mechanistic information on ... prosthetic group commonly employed, and iron- containing dioxygenases have been widely studied [3,4]. In contrast, less information is available on copper-containing dioxygenas...
Ngày tải lên: 22/02/2014, 07:20
Báo cáo Y học: Subsite mapping of the binding region of a-amylases with a computer program ppt
... glycone and two aglycone binding sites. Calcula- tions for barley a-amylase justify the ‘6 + 2 + (1) model’ prediction. Thebinding areaof barleya-amylase is composed ofsix glycone, two aglycone ... subsite at the nonreducing end of the binding site and there are two glycone and five aglycone binding sites. The rice model may be reminiscent of the action of the bacterial malto...
Ngày tải lên: 08/03/2014, 09:20