Báo cáo y học: " Varied sensitivity to therapy of HIV-1 strains in CD4+ lymphocyte sub-populations upon ART initiation" docx
Báo cáo y học: " Varied sensitivity to therapy of HIV-1 strains in CD4+ lymphocyte sub-populations upon ART initiation" docx
... 7:42http://www.aidsrestherapy.com/content/7/1/42Page 5 of 8RESEA R C H Open Access Varied sensitivity to therapy of HIV-1 strains in CD4+ lymphocyte sub-populations upon ART initiationEdwin J Heeregrave1, ... lifespan of infected cells and viral latency prevent eradication. In this study we analyzed the sensitivity to ART of HIV-1 strains in naïve, central memory and effector memory CD4+ lymphocyte subsets.Methods: ... before initiation of therapy (B) Phylogeny of the strains isolated after therapy initiation. The black curved lines indicate strains from the effector memory population and the white curved lines indicate...
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Báo cáo y học: "Clinical response to discontinuation of anti-TNF therapy in patients with ankylosing spondylitis after 3 years of continuous treatment with infliximab" ppsx
... Ankylosing Spondylitis Disease Activity Index; BASFI, Bath Ankylosing Spondylitis Function Index; BASMI, Bath Ankylosing Spondylitis Metrology Index; CRP, C-reactive protein; ESR, erythrocyte ... and investigation of the patients,study coordination. MR: Monitoring and investigation of thepatients, study coordination. JS: Investigator, writing of themanuscript. JB: Idea, writing of the ... S, Jenkinson T, Kennedy LG, Whitelock H, Gaisford P,Calin A: A new approach to defining disease status in ankylos-ing spondylitis: the Bath Ankylosing Spondylitis Disease Activ-ity Index....
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Báo cáo khoa học: Enhanced sensitivity to hydrogen peroxide-induced apoptosis in Evi1 transformed Rat1 fibroblasts due to repression of carbonic anhydrase III docx
... andinteract with histone deacetylase. Br J Haematol 114,566–573.33 Yatsula B, Lin S, Read AJ, Poholek A, Yates K, YueD, Hui P & Perkins AS (2005) Identification of bindingsites of EVI1 in ... variety of inducers of apoptosis, theeffects of H2O2have not yet been examined. Rat1 cellsand 5.61 cells were exposed to various concen-trations of H2O2and cell viability monitored by ... directly or indi-rectly modulates transcription of this gene in Rat1 cells. Targeted knock-down of caIII alone, with Dicer-substrate short inhibitory RNAs, alsoincreases the sensitivity of Rat1...
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Báo cáo y học: "An open pilot study of zonisamide augmentation in major depressive patients not responding to a low dose trial with duloxetine: preliminary results on tolerability and clinical effects" ppsx
... of Psychiatry, University of Genova,Genoa, Italy.2Department of Hematology and Oncology, Section of Semeiotics and Medical Methodology I, University of Genova, Genoa, Italy.3Department of ... at 25 to 50 mg/day to commonly used anti-Parkinsonian drugs,significantly improved the primary symptoms of patientswith advanced Parkinson’s disease, possibly by activatio n of dopamine synthesis, ... study rath eraimed to investigate the role of the combination of thetwo drugs, and the unusual choice of the SNRI duloxe-tine (mainly metabolized by CYP1A 2 and CYP2D6) wasessentially due to...
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Báo cáo y học: "Refractive Status and Prevalence of Refractive Errors in Suburban School-age Children"
... refused to continue the examinations due to eye discomfort during cyclopentolate administration (e.g., burning, photophobia, irritation); and 5) children who moved eyeballs excessively during ... and keratometry, due to the incon-venience in transporting auxiliary equipment on rugged mountain roads in the study regions, should be considered a weakness of this study. In summary, our ... used to identify children aged 6-15 years in Yongchuan, a socio-economically repre-sentative area in Western China. We carried out a door -to- door survey and actual eye examinations, including...
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Báo cáo Y học: A model for recognition of polychlorinated dibenzo-p-dioxins by the aryl hydrocarbon receptor docx
... mediated by binding to a speci®ccytoplasmic protein, the aryl hydrocarbon receptor (AhR)[1].Ligand-induced activation of AhR initiates a processwhereby t he receptor i s transformed into a nucleartranscription ... domain does not bind aligand [11], both the FixL PAS domain and PYP areactivated by ligands; in FixL, oxygen binding at the hemebinding PAS domain controls the activity of a h istidinekinase ... ItalyLigand binding by the aryl hydrocarbon receptor (AhR), amember of the bHLH-PAS family of transcriptional reg-ulatory proteins, has been mapped to a region within thesecond ÔPASÕ domain,...
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Báo cáo y học: "Magnetic resonance imaging changes of sacroiliac joints in patients with recent-onset inflammatory back pain: inter-reader reliability and prevalence of abnormalities" potx
... 46History of inflammatory bowel disease present (%) 15History of uveitis present (%) 15History of psoriasis present (%) 24Family history of ankylosing spondylitis present (%) 37aForty-five of ... haveproposed a scoring system for MRI abnormalities of the SIjoints, which distinguished inflammatory activity as well as jointdamage [11]. Inter-observer reliability in this study, whichincluded 41 ... changes in SI joints in patients with early inflammatory back pain. Assess-ing bone marrow and/or subchondral bone enhancement suf-fices to detect inflammation. Inflammation in the joint space,the...
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Báo cáo y học: "RANKL increases the level of Mcl-1 in osteoclasts and reduces bisphosphonate-induced osteoclast apoptosis in vitro" pps
... survival.Mcl-1 inhibits activation of the mitochondrial pathway of apop-tosis by interacting with pro-apoptotic Bcl-2 family proteinssuch as Bak and Bim, thereby preventing the increased mito-chondrial ... rapidly in mouse osteoclasts following cytokine starvation but are restored by pro-survival factorsMcl-1 levels decrease rapidly in mouse osteoclasts following cytokine starvation but are restored ... preventing joint destruction in rheumatoidarthritis has generally been disappointing. We examinedwhether the ability of bisphosphonates to induce osteoclastapoptosis and inhibit bone resorption in...
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Báo cáo y học: " Microarray-based genomic surveying of gene polymorphisms in Chlamydia trachomatis" ppsx
... evolution: a billion years andcounting. In Chlamydial Infections, Proceedings of the Tenth InternationalSymposium on Human Chlamydial Infections:16-21 June 2002. Antalya,Turkey Edited by: Schacter ... effect on levels of secretion [24]. By analogy, changes in the fliN gene of C. tra-chomatis may have resulted in altered phenotypes, leading to an increase in fitness for a particular biological ... classified as being variablewithin all strains of a biological niche; interestingly, themajority of these genes code for hypothetical proteins of unknown function. With such globally low differencesbetween...
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Báo cáo y học: "Defining the chromatin signature of inducible genes in T cells" pps
... Department of Medicine/Hematology-Oncology, Weill Cornell Medical College, 68th St, New York, NY 10065, USA. ‡Current address: Departments of Physiology and Pathology, National Laboratory of ... displayed active chroma-tin marks in several cell types, including embryonic stemcells, and suggested that primary response genes thatrespond to a variety of signals in many cell types may betagged ... The inability to detect Pol II on somesecondary response genes may relate to the affinity of theantibody coupled with the degree of induction.Additionally, we examined Pol II recruitment to...
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