Báo cáo y học: "Inhibition of human immunodeficiency virus type-1 by cdk inhibitors" pdf

... Access Inhibition of human immunodeficiency virus type-1 by cdk inhibitors Irene Guendel 1,3† , Emmanuel T Agbottah 2† , Kylene Kehn-Hall 3 , Fatah Kashanchi 1,3,4* Abstract Current therapy for human immunodeficiency ... binding of cdk9 /cyclin T1 to TAR RNA [21]. Recently, a growing body of evidence has indicated the role of yet another cyclin /cdk complex, namely c...

Ngày tải lên: 10/08/2014, 05:21

... 56–00% of the surface covered by syncytial = fusion; partial inhibition of fusion: < 10% of the surface is covered by syncytial = P; inhibition of syncytia formation = I. Statistical analysis Data ... (1.15) I (3.52) § F = 50–60% of the surface is covered by syncytia; P = partial inhibition of fusion: < 10% of the surface is covered by syncytia; I = inhibition o...

Ngày tải lên: 18/06/2014, 22:20

... 56–00% of the surface covered by syncytial = fusion; partial inhibition of fusion: < 10% of the surface is covered by syncytial = P; inhibition of syncytia formation = I. Statistical analysis Data ... (1.15) I (3.52) § F = 50–60% of the surface is covered by syncytia; P = partial inhibition of fusion: < 10% of the surface is covered by syncytia; I = inhibition o...

Ngày tải lên: 20/06/2014, 04:20

... Ordered processing of the human immunodeficiency virus type 1 GagPol precursor is influenced by the context of the embedded viral protease. J Virol 2005, 79(16):10601-10607. 7. Pettit SC, Everitt LE, Choudhury ... Choudhury S, Dunn BM, Kaplan AH: Initial cleavage of the human immunodeficiency virus type 1 GagPol precursor by its activated protease occurs by an intramol...

Ngày tải lên: 10/08/2014, 05:21

... ger splicing inhibition by Cl-tetracycline may be explained by the a dditional s ize and hydrophobicity introduced by the substitution, as is often the case in ribozyme inhibition by tetracyclines [33,39,43]. In ... of chlorine for hydrogen at position 7 (Fig. 1C). Inhibition by Cl-tetracycline w as found to be sixfold more t han by tetracycline (Fig. 2). The extent of splicin...

Ngày tải lên: 21/02/2014, 15:20

... inhibition of platelet aggregation [6,7] and inhibition of inflammatory cytokine production in macrophages [8]. Curcumin has also been shown to affect the activity of a number of key enzymes such as cyclooxygenase ... E. (1997) Inhibition of proliferation and apoptosis of human and rat T lymphocytes by curcumin, a curry pigment. Biochem. Pharmacol. 54, 899–907. 35. Orrenius, S....

Ngày tải lên: 08/03/2014, 23:20

... collagen-induced arthritis; DMSO = dimethylsulfoxide; FLS = fibroblast-like synoviocytes; FPP = farnesylpyrophosphate; GGPP = geranylger- anylpyrophosphate; HMG = hydroxymethylglutaryl; IL = interleukin; OA ... the destruction of cartilage and underlying bone as a conse- quence of pro-inflammatory cytokines and proteases [1]. Much of the pathology is thought to be driven by cytokines,...

Ngày tải lên: 09/08/2014, 08:22

... be constitutively expressed on human and mouse kidneys and TLR2 deficiency protects from the renal ischemia- Effect of AG-490 on kidney dysfunction induced by zymosanFigure 2 Effect of AG-490 on kidney dysfunction ... 3 Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome, Italy Email: Petya Dimitrova* - petya_dimitrova@web.de; Val...

Ngày tải lên: 11/08/2014, 08:22

... http://www.aidsrestherapy.com/content/3/1/15 Page 8 of 12 (page number not for citation purposes) by 81% on day 14 after infection. By comparison, virus inhibition by ddC was 72% on day 3, and thereafter remained ... Repli- cation of different clones of human immunodeficiency virus type 1 in primary human fetal astrocytes: enhancment of viral gene expression by Nef....

Ngày tải lên: 10/08/2014, 05:20

... filtration of GLP-1 through kidney [15]. Although structural modifica- tion of GLP-1 may overcome degradation by dipep- tidyl peptidase IV, this does not address the loss of GLP-1 by renal filtration ... were analyzed by SDS-PAGE and Western blot anal- ysis. Assay of glucose-lowering effect of gAd-GLP-1-A fusion protein Male KM mice were housed at 23-25°C in a 12-hour l...

Ngày tải lên: 25/10/2012, 11:10