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Báo cáo y học: "Further benefits by early start of HIV treatment in low income countries: Survival estimates of early versus deferred antiretroviral therapy" potx

Báo cáo y học:

Báo cáo y học: "Further benefits by early start of HIV treatment in low income countries: Survival estimates of early versus deferred antiretroviral therapy" potx

... CD4 starting points isnecessary information for making informed choicesabout early or late start of treatment. Studies in low income countries have found that patients startingHAART early (CD4 ... Abo Y, Salamon R, Bissagnene E, Seyler C, Eholié S, Anglaret X: Incidence anddeterminants of mortality and morbidity following early antiretroviral therapy initiation in HIV- infected adults in ... patients starting treatment in earlierstages of HIV may reflect either earlier treatment initia-tion or delay in time of death. Therefore, to avoid overes-timates of the actual impact of early treatment...
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Báo cáo Y học: Calcium-binding by p26olf, an S100-like protein in the frog olfactory epithelium pot

Báo cáo Y học: Calcium-binding by p26olf, an S100-like protein in the frog olfactory epithelium pot

... K1con-centration, 80– 90% of the change in the a helix contentwas attained by binding of two Ca21. Interestingly, in themutants which have only three Ca21-binding sites, thebinding of two Ca21was ... constants of thefirst to fourth binding of Ca21 by assuming the presence of four steps of sequential and ordered binding. To identify thesite of the EF-hand corresponding to the nth binding of Ca21, ... changes induced by thesecond Ca21-binding increase the affinity of EF-C to inducethe third Ca21-binding.(c) Finally, the fourth Ca21-binding takes place at EF-Dwith high affinity.Although...
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Báo cáo y học: "DAS28: a useful instrument to monitor infliximab treatment in patients with rheumatoid arthritis" pps

... remission, low disease activity, moderatedisease activity and high disease activity [7]. Interestingly, thecut-off criteria for the DAS28 that were found in this waywere only slightly different ... Activity Score and theDAS28. In a study performed in Italy in the late 1990s, it wasfound that the Disease Activity Score was the best measureto discriminate between predefined states of low ... activity, in a sample of 202 patients [6]. A recentstudy used a different, opinion-based, approach, with expertrating (n = 35) of a sample of clinical profiles that werecategorised into remission,...
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Báo cáo y học:

Báo cáo y học: "PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease" ppsx

... combination gave aspecificity of 100% for diagnosing RA.IntroductionA single nucleotide polymorphism in the PTPN22 gene encod-ing the lymphoid protein tyrosine phosphatase (Lyp) hasrecently ... from arginineinto tryptophan. This amino acid change disrupts the binding of Lyp to an intracellular kinase, Csk, which can then no longerinactivate another kinase, Lck, that is involved in T-cell ... of the controls had this combination, the ORwas calculated assuming one individual did, resulting in avalue of 132.03, although the relative risk was actually infinite(Table 3). Carriage of...
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Báo cáo y học: "Adherence to anti-retroviral therapy among HIV patients in Bangalore, India" pps

... translator. A study conducted by Hautzinger Met al in 2006 showed that patients are more likely toinform their doctor why they take, than why they do nottake, ART [22]. Only half of those who were ... taking all medications as prescribed since starting treatment. $ Missed medications means not taking a prescribed medication on any day as prescribed by the physician.@ GI symptoms = Gastrointestinal ... effects.From the findings of this study, we noted that patient'sholding their own notes makes follow up by professionalsdifficult in out patient's clinic setting along with affecting100%...
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Báo cáo Y học: Agmatine oxidation by copper amine oxidase Biosynthesis and biochemical characterization of N-amidino-2-hydroxypyrrolidine pdf

Báo cáo Y học: Agmatine oxidation by copper amine oxidase Biosynthesis and biochemical characterization of N-amidino-2-hydroxypyrrolidine pdf

... conversion of L-arginine toL-citrulline (at pH 7.5and 37.0 °C) and of the trypsin catalyzed hydrolysis of N-a-benzoyl-L-arginine p-nitroanilide (at pH 6.8 and21.0 °C) by N-amidino-2-hydroxypyrrolidine ... presence of N-amidino-2-hydroxypyrrolidine as thesubstrate instead of L-arginine, at pH 7.5 ( 5.0 · 10)2MHepes buffer) and 37.0 °C [18,19].Trypsin assayThe trypsin catalyzed hydrolysis of N-a-benzoyl-L-argininep-nitroanilide ... N-Amidino-2-hydroxypyrrolidine binding mode tohuman NOS-II(top) and bovine trypsin (bottom). The conformations of N-amidino-2-hydroxypyrrolidine in the enzyme:inhibitor complexes were ob tainedafter...
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Báo cáo Y học: Conformational analysis by CD and NMR spectroscopy of a peptide encompassing the amphipathic domain of YopD from Yersinia potx

Báo cáo Y học: Conformational analysis by CD and NMR spectroscopy of a peptide encompassing the amphipathic domain of YopD from Yersinia potx

... class of Yersinia Yop proteins. Infect. Immun. 61, 71–80.39. Slupsky, C.M., Kay, C.M., Reinach, F.C., Smillie, L.B. & Sykes,B.D. (1995) Calcium-induced dimerization of troponin C: mode of interaction ... designed synthetic peptidesencompassing theC-terminal amphipathicdomain of YopD.A solution structure of YopD278)300, a peptide that stronglyinteracted with LcrH, was obtained by NMR methods. ... 2,2,2-trifluoroethanol.Injection of anti-host factors into eukaryotic cells by numerous economically important animal- and plant-inter-acting Gram-negative bacteria is achieved by functionallyhomologous Ôtype...
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Báo cáo y học: "Specific immunotherapy by the sublingual route for respiratory allergy" pot

... evaluation of sublingualimmunotherapy vs symptomatic treatment in adults with pollen-induced respiratory allergy: The Sublingual Immunotherapy PollenAllergy Italy (SPAI) study. Ann Allergy Asthma ... onemeta-analysis. J Investig Allergol Clin Immunol 2005, 15:9-16.11. Penagos M, Compalati E, Tarantini F, et al: Efficacy of sublingualimmunotherapy in the treatment of allergic rhinitis in pediatric ... Scadding GK, Brostoff J: Low dose sublingual therapy in patients withallergic rhinitis due to house dust mite. Clin Allergy 1986, 16:483-491.8. Tari MG, Mancino M, Monti G: Efficacy of sublingual...
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Báo cáo y học: "All-trans retinoic acid suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2 pathway independently of RAR activation" ppsx

... suppresses interleukin-6 expression in interleukin-1-stimulated synovial fibroblasts by inhibition of ERK1/2 pathway independently of RAR activationMélanie Kirchmeyer, Meriem Koufany, Sylvie ... only ATRAinhibited IL-1-induced IL-6 expression in rat synovial fibroblasts by inhibiting ERK1/2 pathway and subsequent activation of AP-1and NF-IL-6 independently of RAR.IntroductionRetinoids ... to its inhibitory effect onFigure 2Effect of retinoids on interleukin-1-beta (IL-1β)-induced expression of IL-6 in synovial fibroblastsEffect of retinoids on interleukin-1-beta (IL-1β)-induced...
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Báo cáo y học: "Collagen type II (CII)-specific antibodies induce arthritis in the absence of T or B cells but the arthritis progression is enhanced by CII-reactive T cells" ppsx

... reactivity of the clonallydistinct glycopeptide-reactive T cells [7].To investigate the role of T cells in the acute effector stage of clinical arthritis, newly activated T cells were injected intoQD ... antigen-presenting cells/ml, 10 µg/ml rat CII) followed by 2 weeks of resting in medium containing IL-2. At the time of re-stim-ulation, an aliquot of the cell line was tested for antigen spe-cificity. ... assay as described previously [18].Arthritis developmentDevelopment of clinical arthritis was followed by means of visual scoring of the mice. Mice were examined daily or onalternate days for...
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