Báo cáo y học: " Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept®, Roche): overview" ppsx

... bottles of nelfi- navir, including one patient reporting nausea and vomit- ing. Investigations revealed that there were elevated levels of ethyl methanesulfonate (EMS) in nelfinavir batches produced ... Corresponding author Abstract Roche's protease inhibitor nelfinavir mesylate (Viracept ® ) produced between March 2007-June 2007 was found to contain elevated levels...

Ngày tải lên: 10/08/2014, 05:21

... El-Shabrawi YG, Christen WG, Foster SC: Correlation of metal- loproteinase-2 and -9 with proinflammatory cytokines inter- leukin-1β, interleukin-12 and the interleukin-1 receptor antagonist in patients ... expression of a 92-kD gelatinase (type V collagenase) by rheumatoid syno- vial fibroblasts and its induction in normal human fibroblasts by inflammatory cytokines. J Clin Invest 1991, 8...

Ngày tải lên: 09/08/2014, 06:22

... [1,2]. However, in muscle cells, Trip10 inhibits glucose uptake by increasing Glut4 endocytosis [3,4]. In natural killer cells, Trip10 regulates actin cytoskeleton dynamics by interacting with WASP protein ... Trip10 is hypermethylated in brain tumor and breast cancer, but hypomethylated in liver cancer. Overexpressed Trip10 was associated with endogenous Cdc42 and huntingtin in IMR...

Ngày tải lên: 10/08/2014, 05:21

... played by cytokines in the evolution of insulin resistance. Could hyperhomocysateineamia be a result of derangement of certain cytokine production? Abbreviations tHcy: total homocysteine; ... homocysteine levels in the insulin resistance syndrome: the Framingham offspring study. Diabetes Care. 2001;24(8):1403-10. 69. McCarty MF. Insulin secretion as a potential determinant of homocy...

Ngày tải lên: 03/11/2012, 09:49

... macrophage lineage cells, CD55 for synovial fibroblasts in the synovial lining layer, CD22 for B cells and CD3 for T-lymphocyte lineage cells. Detection of apoptosis by TUNEL staining Terminal deoxynucleotidyl ... roles in determining whether apoptosis occurs. Apoptosis in active RA may be important as a way of limiting inflammation by reducing the number of inflammatory cells and could...

Ngày tải lên: 09/08/2014, 01:22

... imaging system. There was a significant (30%) increase in safranin O staining intensity in the patella on day 7. When the data of all time points were pooled, a significant increase in safranin ... purposes) cytokine-induced and mechanically induced injury. The BMP- 2-induced elevated degradational activity is most likely an attempt to clear away old matrix molecules to make room for...

Ngày tải lên: 09/08/2014, 10:21

... immunoglobulin synthesis. Both anti-CCP and RF-IgM were significantly enriched in synovial tissues containing lym- phoid aggregates. However, in an 8-week study, autoantibody production in RA synovia ... the two types of synovia. The large vari- ability observed in autoantibody concentrations in RA extracts might be explained by varying tissue serum content and/or var- ying autoanti...

Ngày tải lên: 09/08/2014, 13:21

... overall mortality of HIV-infected individuals is increasingly influenced by deaths that would have occurred regardless of HIV infection. Although based on small numbers, differences in the magnitude ... Outpatient Study Investigators: Mortality in the highly active antiretroviral therapy era. Changing causes of death and disease in the HIV outpatient study. J Acquir Immune Defic Syndr...

Ngày tải lên: 10/08/2014, 05:21

... and insulin were measured consecutively in the hos- pital's laboratory. The method for measuring insulin was the same throughout the study period via routine bio- chemistry lab protocols. In ... Accumulating evidence does indicate that elevated levels of endotoxin may, indeed, play a role in metabolic disease [13,14]. Notably, endotoxin seems to promote liver fibrogenesis by stim...

Ngày tải lên: 11/08/2014, 03:20

... and insulin were measured consecutively in the hos- pital's laboratory. The method for measuring insulin was the same throughout the study period via routine bio- chemistry lab protocols. In ... contribute to low-grade systemic inflammation in insulin resistant states. This study aimed to examine the importance of serum endotoxin and inflammatory markers in non-alcoholic fatty li...

Ngày tải lên: 11/08/2014, 06:22