Báo cáo y học: " Genetic polymorphisms in glutathione S-transferase (GST) superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern Taiwan" ppt
Báo cáo y học: " Genetic polymorphisms in glutathione S-transferase (GST) superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern Taiwan" ppt
... glutathione S-transferase (GST) superfamily and risk of arsenic-induced urothelial carcinoma in residents of southwestern Taiwan. Journal of BiomedicalScience 2011 18:51.Hsu et al. Journal of Biomedical ... CJ, Pu YS, Su CT, Huang YK, Chen YT, Hsueh YM: Urinary8-hydroxydeoxyguanosine and urothelial carcinoma risk in low arsenicexposure area. Toxicol Appl Pharmacol 2008, 226:14-21.19. Huang YL, Hsueh ... risk of arsenic-induced urothelial carcinoma in residents of southwestern TaiwanLing-I Hsu1, Wu-Ping Chen1, Tse-Yen Yang1, Yu-Hsin Chen1, Wann-Cheng Lo1, Yuan-Hung Wang2,3, Ya-Tang...
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Báo cáo y học: "Genetic polymorphisms in the nucleotide excision repair pathway and lung cancer risk: A meta-analysis"
... common polymorphisms in DNA repair genes are continuously being identified, and these polymorphisms may play a pivotal role in sporadic carcinogenesis. A growing body of literature, including observations ... Continued advances in SNP maps and in high-throughput genotyping methods will facilitate the analysis of multiple polymorphisms within genes and the analysis of multiple genes within pathways. ... lesions. These clinical findings are associated with cellular defects, including hypersensitivity to killing and the mutagenic effects of UV and the inability of XP cells to repair UV-induced DNA...
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Báo cáo y học: "Genetic polymorphisms in PTPN22, PADI-4, and CTLA-4 and risk for rheumatoid arthritis in two longitudinal cohort studies: evidence of gene-environment interactions with heavy cigarette smoking" potx
... growingunderstanding of how genetic and environmental factors inter-act in RA pathogenesis, and suggest that heavy cigarette smok-ing and PTPN22 may be acting in a similar mechanisticpathway.Competing ... results of their study are slightly different from ours, in that they did notfind a significant interaction between the presence of thePTPN22 polymorphism and smoking in determining RA risk. Their ... potential interactions between the three polymor-phisms of interest and the amount and duration of cigaretteTable 4Effect of PTPN22, CTLA-4, and PADI-4 genotypes and the risk of RA in NHS, NHSII and...
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Báo cáo y học: "Advanced glycation end-product (AGE)-damaged IgG and IgM autoantibodies to IgG-AGE in patients with early synovitis." ppt
... is induced by AGE,can contribute to the inflammatory cycle by the induction of proinflammatory cytokines, via the nuclear factor-κBpathway [21]. No studies have yet examined RAGEexpression in ... basis of having peripheral joint synovitis and not axialdisease, the presence of ‘inflammatory spinal pain’, whenpresent, was insufficient as the only major EuropeanSpondlyarthropathy Study Group ... withinflammatory arthritis of duration less than 1 year. Patients wereevaluated clinically and serologically, and radiographs wereobtained at initial and 1-year visits. Sera were assayed for IgG-AGE and...
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Báo cáo y học: " Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells" docx
... TLR3agonist, polyinosinic-polycytidylic acid (poly(I:C)), on the growth of human NB cells was evaluated by WST-1 cellproliferation assay, flow cytometry analysis, and immunoblot analysis. Blockade of TLR3 ... TLR3 signaling was achievedusing TLR3 neutralizing antibody, small interference RNA, and 2-aminopurine (2-AP), an inhibitor of protein kinase R(PKR), an interferon-induced, double-stranded RNA-activated ... wavelength of 450 nm and referencewavelength of 630 nm.Flow cytometry analysisThe percentage of cells in G0/G1, S, and G2/M phaseswas determined by flow cytometry analysis followingpropidium...
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Báo cáo y học: "Levamizole enhances immune responsiveness to intra-dermal and intra-muscular hepatitis B vaccination in chronic hemodialysis patients" pps
... maintaining hepatitis B immunity in hemodialysispatients. vaccine 2002, 20:3230-35.21. Pyone kyi K, May Oo K, Moh Htun M, Win Maw T, Khin Khin A, SanSan O, et al.: Clinical trial of the intradermal ... analternative method of vaccination which could be moreeffective than the conventional intramuscular (IM) rout. Itis effective in inducing HBs antibody production byincreasing T and B lymphocyte responsiveness, ... upon dose administeredthe timing of its administration and host genetic back-ground [30]. Levamisole also could induce an increase in the level of interleukin 2 receptor [31] and T helper to...
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Báo cáo y học: "PLCb1-SHP-2 complex, PLCb1 tyrosine dephosphorylation and SHP-2 phosphatase activity: a new part of Angiotensin II signaling?" ppt
... ‘Shp’ing news: SH2 domain-containing tyrosinephosphatases in cell signaling. Trends Biochem Sci 2003, 28:284-93.24. Qu CK: Role of the SHP-2 tyrosine phosphatase in cytokine-inducedsignaling and ... I,Semplicini A, Pessina AC: Silencing regulator of G protein signaling-2(RGS-2) increases angiotensin II signaling: insights into hypertensionfrom findings in Bartter’s/Gitelman’s syndromes. J Hypertens ... Italy toLDM.Author details1Department of Clinical and Experimental Medicine, Clinica Medica 4University of Padova, School of Medicine, Italy.2Department of BiologicalChemistry, University...
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Báo cáo y học: "Genetic control of disease in an experimental model for Sjögren’s syndrome Åsa Andersson" potx
... hereditary and environmental factors. Thedisease is characterized by lymphocytic infiltration and inflam-mation in the salivary and lacrimal glands, leading to oral and oculardryness. To understand ... development of autoimmune exocrino-pathy in the NOD mouse and by reducing one of these regionsconsiderably, Nguyen et al. in a recent issue of Arthritis Research and Therapy propose candidate ... recombinant inbred strains with over-Editorial Genetic control of disease in an experimental model forSjögren’s syndromeÅsa AnderssonDepartment of Pharmacology and Pharmacotherapy, Faculty of...
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Báo cáo y học: "Regulatory polymorphisms in extracellular matrix protease genes and susceptibility to rheumatoid arthritis: a case-control study" ppsx
... recipient of a scholarship of the National Program for the Training of University Professors of the Spanish Ministry of Education. AG was supported by the Instituto de Salud Carlos III (Spain).References1. ... toascertain the specific participation of each of them in RA. As agroup, they are the major actors in the degradation of ECM in RA cartilage and bone. In addition, they increase and perpetu-ate joint ... unambiguously in 99.7% of the samples, and confirmed by sequencing a fraction of them. The genotype dis-tributions of all SNPs were in concordance with the Hardy-Weinberg equilibrium. Genetic susceptibility...
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Báo cáo y học: "Cytokine polymorphisms influence treatment outcomes in SLE patients treated with antimalarial drugs" ppsx
... actions of cytokines may be profoundly conditioned bythe presence of other cytokines, this being particularly true in the case of IL-10 and TNFα, which are mutually regulated and have complex and ... (73.61 and 59.97, respectively).Combined IL-10 and TNFα genotype influences response to antimalarial treatment in SLE patientsFinally, in order to examine the role of IL-10 and TNFα genetic polymorphisms ... and TNFα cytokine polymorphisms separately,comparing the high producer genotypes with the most com-mon low producers. A combined two-loci model was devel-oped, including both cytokine polymorphisms...
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