... stimulated byfeeding, histamine, or gastrin. Mucus secretion in the stomach and small intestine are enhanced by PGE2. Theseeffects help to maintain the integrity of the gastric mucosa. In ... functioningenzyme that has a catalytic activity for the reduction of the 13,14-double bond of 15-keto-PGs in the presence of NADHor NADPH, and the oxidation of the 12-hydroxy group of LTB4 in the ... kidney,epithelial cells of airway, alveoli, epithelial cells in smallintestine and stomach, and hepatocytes were found to express the enzyme. These findings will lead to the identification of the unrevealed...