Báo cáo y học: "Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways" pot

... Sirard 1, § and Emanuela Felley-Bosco 2 1 Swiss Experimental Cancer Research Center, Epalinges, Switzerland 2 Institute of Pharmacology and Toxicology, Lausanne, Switzerland The inducible nitric oxide synthase ... processes. Abbreviations DOC, sodium deoxycholate; iNOS, inducible nitric oxide synthase; NO, nitric oxide; TX-100, Triton X-100. 444 FEBS Journal 272 (2005) 4...

Ngày tải lên: 19/02/2014, 16:20

... leptin/IL-1-induced nitric oxide (NO) production and nitric oxide synthase (NOS) type II protein expression. Effect of tyrphostin AG490 and Tkip on NO production and NOS II protein expression. The effect of tyrphostin ... nitric oxide synthase (NOS) type IILeptin synergizes with IL-1 in inducing nitric oxide synthase (NOS) type II. Synergistic effect of leptin (...

Ngày tải lên: 09/08/2014, 06:22

... Access Aciculatin inhibits lipopolysaccharide-mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing NF-B and JNK/p38 MAPK activation pathways I-Ni Hsieh 1 , Anita Shin-Yuan ... al.: Aciculatin inhibits lipopolysaccharide- mediated inducible nitric oxide synthase and cyclooxygenase-2 expression via suppressing...

Ngày tải lên: 10/08/2014, 05:21

... stimulated inducible nitric oxide synthesis level and activity while stimu- lating cyclooxygenase-2 synthesis in human osteoarthritic chondrocytes. J Rheumatol 1998, 25:2417-2424. 17. Yaron M, ... osteoclasts by targeting transcription factors with decoy molecules. Ann N Y Acad Sci 2006, 1091:509-516. 44. Huang YH, Zhen YS: [Rhein induces apoptosis in cancer cells and shows syne...

Ngày tải lên: 09/08/2014, 10:23

... [20] with BSA as standard. RESULTS Synthesis, purification and analysis of wild-type and mutant oxaloacetate decarboxylases in E. coli To synthesize mutant oxaloacetate decarboxylases, mutated DNA ... considerations, Y2 29 is the more likely candidate for this function: (a) a phenol hydroxyl is a much better acid than an aliphatic alcohol; (b) the hydroxyl of Y2 29 is absolutely essentia...

Ngày tải lên: 08/03/2014, 23:20

... cell layers to appear during mammalian embryogenesis and is, most likely, homologous to the simpler amphibian and avian cortical structures (Figure 5a(i,ii,iv,v)) [38]. At embryonic day 17 (E17), ... Asbury A, Cheung T, Cornelius T, Batten DM, Eden C, Norland SM, Rice DS, Dosooye N, Shakya S, Mehta P, Curran T: BGEM: an in situ hybridization database of gene expression in the embryonic...

Ngày tải lên: 09/08/2014, 20:22

Ngày tải lên: 09/08/2014, 23:20

... applied intermittently and repeatedly day by day at 1 h per day. Prolonged expo- sure to HBO causes signific antly toxicity effects to the neurologic system as well as to any cultured cells. The visfatin ... also applied intermittently and repeatedly day by day at 1 h per day. The visfatin protein level increased by intermittent and repeat exposure was simi- lar to that by 6 hr HBO expo...

Ngày tải lên: 10/08/2014, 05:21

... Acetylation of human prostaglandin endoperoxide synthase- 2 (cyclooxygenase-2) by aspirin. J Biol Chem 1994, 269:13207-13215. 37. Vane J, Bakhle Y, Botting R: Cyclooxygenases 1 and 2. Annu Rev Pharmacol Toxicol ... present study found that arctiin significantly inhibited the effects of LPS by suppressing a key inflammatory pathway related to NF-B, PGE 2 and NO production, and pro-i...

Ngày tải lên: 11/08/2014, 03:20

... process, mediated by activated inflammatory and immune cells including macrophages and monocytes [12]. Inflammatory reactions, phagocytosis, natural cytotoxicity, cytokine pro- duction, antibody response, and ... Acetylation of human prostaglandin endoperoxide synthase- 2 (cyclooxygenase-2) by aspirin. J Biol Chem 1994, 269:13207-13215. 37. Vane J, Bakhle Y, Botting R: Cyclooxygenases...

Ngày tải lên: 11/08/2014, 06:23