Báo cáo y học: "Tumor necrosis factor-a enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells" ppt

... Open Access Tumor necrosis factor-a enhances hyperbaric oxygen-induced visfatin expression via JNK pathway in human coronary arterial endothelial cells Bao-Wei Wang 1,2 , Chiu-Mei Lin 3 , Gong-Jhe ... 14 human CAECs. Since JNK kinase inhibitor reduced the visfatin protein expression most significantly. We then focused on the JNK kinase pathway on the...

Ngày tải lên: 10/08/2014, 05:21

... splenocytes. In arthritic mice, TIARP mRNA was expressed mainly in CD11b + cells in the spleen, and TIARP mRNA level was increased in the joints (accompanied by joint swelling), especially in hyperplastic ... also induced by IL-6 [6]. In this study, we confirmed its induction in CD11b + splenocytes in arthritis and we confirmed that it is upregulated in the arthritic synov...

Ngày tải lên: 09/08/2014, 14:22

... that cytokines can be involved in cartilage tissue or proteoglycan degradation [6]. It has recently been shown in a serum-containing porcine in vitro model that these cytokines are able to inhibit ... [29]. TNFα induced a dose-dependent increase in GAG release support- ing data from other investigations on pro-inflammatory cytokines in which IL-1 promoted GAG release in lapine and...

Ngày tải lên: 09/08/2014, 14:22

... TNF-α promotes further expression of cytokines and chemokines by synovial cells and chondro- cytes, thereby sustaining a renewal of local inflammatory mediators (reviewed in [9,10]). The presence ... analysis of signaling pathways, cells were treated prior to addition of TNF-α or EGF with phar- macologic inhibitors including 2-[1-(3-dimethylaminopro- pyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)-...

Ngày tải lên: 09/08/2014, 06:22

... http://arthritis-research.com/content/7/3/R439 123 decrease in the hypervascularity typical of SpA and a reduction of the synovial lining hyperplasia, indicating that infliximab also modulates the structural synovial charac- teristics ... 48(Suppl):S233. 5. Jenkinson T, Mallorie P, Whitelock H, Kennedy L, Garrett S, Calin A: Defining spinal mobility in ankylosing spondylitis (AS). The Bat...

Ngày tải lên: 09/08/2014, 06:23

... anti-inflammatory properties are used in human ther- apy, regulate in vitro CD36 expression. Aspirin increases CD36 expression in lines of human THP1 macrophages [23], dexamethasone induces CD36 expression ... adalimumab, a human anti-TNFα monoclonal antibody widely used in human pathology, in CD36 expression in human monocytes. Human monocytes were prepared by...

Ngày tải lên: 09/08/2014, 10:20

... optimizing pul- monary function. Physiotherapy, including incentive spirometry, should be continued in the postoperative period. Limitations of the study Thepresentstudyshouldbeinterpretedinthelightof some ... Salica A, Frati G, Sani G: Respiratory dysfunction after coronary artery bypass grafting employing bilateral internal mammary arteries: the influence of intact pleura. Eur J Cardiot...

Ngày tải lên: 10/08/2014, 09:21

... N-[(1S,2R)-1-Benzyl-3- (cyclopropylamino)-2-hydroxypropyl]-7-ethyl-1-methyl- 3,4-dihydro-1H-[1,2,5]thiadiazepino[3,4,5-hi-]indole-9- carboxamide 2,2-Dioxide (compound 8e in Charrier et al., 2008) was made in- house ... efficacy on Ab secretion could be achieved by combining BACE and g- secretase inhibitors. Materials and met hods Inhibitors The g-secretase inhibitor (N)-((S)-2-hydroxy-3-me...

Ngày tải lên: 10/08/2014, 10:20

... family of enzymes comprising at least 11 isoforms. These isoforms are characterized by an NH 2 -terminal regulatory domain containing binding sites for Ca 2+ , phosphatidylserine and diacyl- glycerol, ... rapidly stimulates phosphatidylinositol-3-kinase, as well as activating tyrosine phosphorylation. An increase in intracellular levels of cAMP [6,7] and the involvement of kinases, such as...

Ngày tải lên: 07/03/2014, 16:20

... characterized by a well defined domain structure, consisting of a N-terminal prodomain followed by a metalloproteinase domain, a disintegrin domain, a cysteine rich domain, which usually contains an epithelial ... that stimulation of protein kinase C or protein kinase A signaling pathways did not in uence long-term degradation of mature TACE. Interestingly, PMA treatment of furin-deficient LoV...

Ngày tải lên: 08/03/2014, 02:20