Báo cáo y học: "Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy" pptx

... Access Granulocyte-CSF induced inflammation-associated cardiac thrombosis in iron loading mouse heart and can be attenuated by statin therapy Wei S Lian 2,3† , Heng Lin 4† , Winston TK Cheng 5 , ... inflammation -thrombosis circuitry and that leads to intra -cardiac thrombu s formation. This inflamma tion- associated cardiac thrombosis in vivo can be...

Ngày tải lên: 10/08/2014, 05:21

... transcription in human monocytes. Blood 1997, 89:4461. 10. Ding L, Linsley PS, Huang LY, Germain RN, Shevach EM: IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation ... in rheumatoid arthritis by interleukin-10 and interleukin-4. Arthri- tis Rheum 1996, 39:829. 19. Walmsley M, Katsikis PD, Abney E, Parry S, Williams RO, Maini RN, Feldmann M:...

Ngày tải lên: 09/08/2014, 01:21

... leucopenia, thrombocytopenia and C3/C4 decrease. IFIT4 protein was localized exclusively to the cytoplasm, and it was significantly upregulated by IFN-α in normal PBMCs. To determine the role played by IFIT4 in ... kinase Cδ, c-Jun amino-terminal kinase, and STAT1 (signal transducer and acti- vator of transcription 1) [36]. Because IFIT4 can be induced by IFN-α [36], w...

Ngày tải lên: 09/08/2014, 10:23

... conventional eosin and hematoxylin staining of the tissue was not inter- preted as being significant by two independent patholo- gists. The other eosinophil granules such as ECP [10] and EDN [ 11] ... a patient who likely has a lymphocytic variant of hypereosinophilic syndrome that resulted in eosinophilic infiltration of the gastroin- testinal tract, sinuses, and airway that contri...

Ngày tải lên: 08/08/2014, 21:20

... varying degrees of pathology parallel the results obtained exploiting in vitro coculturing systems. Physiologic apoptosis may initiate an inflammatory process via antibody binding and ingestion by ... tissue may be unique to heart block acquired in utero following autoantibody-initiated inflam- mation. Other inflammatory stimuli, as in Lyme disease, induce transient block [26],...

Ngày tải lên: 09/08/2014, 01:22

... previously been shown that a general inhi- bition of cell glycosylation by tunicamycin a llowed receptorrecognitionandinfectiondrivenbyanMLV envelope [27]. W hether, a lack of staining may come from ... of 9 Cerebellum staini ng: the granular layer was irregularly labelled with all three probes, whereas the molecular layer was homogeneously labelled for PiT1 and PiT2 and i rregularly la...

Ngày tải lên: 10/08/2014, 05:21

... dif- ference in survival was determined by using the log-rank test and in case of significance a univariate analysis and Cox-regression analysis was carried out. Results Pathological and Clinical Findings According ... with an incidence of 0.2 – 1.5% worldwide [1]. A larger body of literature has been presented in the last decades providing further insight into tumor biology an...

Ngày tải lên: 10/08/2014, 10:20

... biopsy and stained with hematoxylin-eosin. The whole sections were examined by the same pathologist (US) in a blinded manner. The inflammatory reaction consisted of lymphocytes, macrophages and ... without inflammation [8,10]. H owever, pathological findings have been described in other studies. Dercum originally considered the most interestin g histological finding to be intersti...

Ngày tải lên: 11/08/2014, 03:20

... putres- cine, spermidine and spermine by down-regulating the activity of the polyamine biosynthetic enzymes a nd up-regu- lating the activity of the catabolic enzyme spermidine/ spermine N 1 -acetyltransferase ... etabolic pathway, the induction of SSAT results in the acetylation of spermine and spermidine, which are subsequently oxidized by polyamine oxidase to form spermidine and...

Ngày tải lên: 17/03/2014, 23:20

... expressed in yeast was functional and bound radioactively labelled ecdysteroid specifically. Ligand binding was greatly enhanced by the presence of a USP ligand binding domain. Therefore, ecdysteroids ... assayed by the two-hybrid assay (rI: induced level divided by basal level of b-galactosidase activity): + or – signs mean rI to be signifi- cantly or unsignificantly higher than 1...

Ngày tải lên: 18/03/2014, 01:20