Báo cáo y học: "An update on targeted gene repair in mammalian cells: methods and mechanisms" ppt

... promising for future studies on targeted gene alteration. In this article, we have reviewed the methods currently used in targeted gene repair and the underlying mechanisms. Although c linical gene ... prolonged S-phase may pose problems in clinical applications with many in vivo targets under- going only limited levels of replication and division [46]. Upon invasi...

Ngày tải lên: 10/08/2014, 05:21

... efficacy and the genetic consequences of targeted gene therapy in vitro (and in vivo). Microarray Study Differential Gene Expression Differential gene expression profiling is rou- tinely used ... as CDGSH iron sulfur domain 1 and it is a member of the CDGSH domain-containing family (http://amigo.geneontology.org/cgi-bin/amigo/sea rch.cgi?action=query&view=query&am...

Ngày tải lên: 03/11/2012, 11:44

... Interleukin-1 receptor antagonist delivered directly and by gene therapy inhibits matrix degradation in the intact degenerate human interverte- bral disc: an in situ zymographic and gene therapy study. Arthritis ... preliminary in vitro study into the use of IL-1Ra gene therapy for the inhibition of intervertebral disc degeneration. Int J Exp Pathol 2006, 87:17-28. 39. Le Mait...

Ngày tải lên: 09/08/2014, 14:22

... assembly and/ or annotation could be improved, most likely in or around computa- tionally derived gene models and overlapping genes. In addition, we provide a list of candidate housekeeping genes and ... expected and unexpected associations that, in most cases, confirms the BRENDA ontology and, at least in one case, suggest s additional tissue asso- ciations. The demonstrati...

Ngày tải lên: 09/08/2014, 22:23

... decisions for patients with AIDS who are undergoing HAART are commonly based on clinical treatment history data, ideally including VL, CD4 and genotype information with adherence assumed, based on practical ... showed that life expectancy at age 20 years had increased by over 13 years since the introduction of combination antiretro- viral therapy and currently life expectancy of HIV p...

Ngày tải lên: 10/08/2014, 05:21

... contain phytochemicals which are capable of arresting wound bleeding , prevent- ing the gro wth of wound contaminating microbes and accelerating wound healing [22]. Similar phytochemical analyses ... educational and job opportunities and the commonly h eld view by young people that traditional medicine is superstitious and something for the poor and uneducated may result to a loss o...

Ngày tải lên: 10/08/2014, 09:20

... conduits for nerve reconstruction, and clinical applications, such as tubuli- zation and end-to-side neurorrhaphy. The international and multidisciplinary panel of papers addressed, from many ... need for defining innovative strategies for improving the success of recovery after nerve lesion and repair and this meeting was intended to discuss, from a multidisciplinary point of v...

Ngày tải lên: 10/08/2014, 10:20

... immunoglobulin G4 (IgG4)-rich lymphoplasmacy- tic infiltration. The pancreas, biliary tree, salivary glands, retroperitoneum, lymph nodes and kidneys can be involved in this systemic fibrotic condition ... cor- ticosteroid therapy. A thorough evaluation by experienced multi-disciplinary team is critical in diag- nosing AIP, especially in young patients. Clinical suspi- cion of the ent...

Ngày tải lên: 10/08/2014, 23:21

... found questions relating to promotions, salary, and training to be very sensitive and seemed guarded when addressing these issues. In line with our conceptual framework and our intention to provide ... were piloted in two, non-study public hospitals in Kenya to test for clarity of questions, health workers' comprehension of the tools, and to gain preliminary insight into re...

Ngày tải lên: 11/08/2014, 05:21

... direction after its initial effect on protein kinases phosphorylation. The most strikingly and novel finding obtained hereby was the strong inhibition of the GPCR signaling pathway induced mainly ... pro-apoptotic effect induced by ethanol was demonstrated by a strong inhibition of GPCR signaling pathway in association with a slight inhibition of JNK and NFκB signaling in as...

Ngày tải lên: 31/10/2012, 15:37