Báo cáo y học: "The discovery of potential acetylcholinesterase inhibitors: A combination of pharmacophore modeling, virtual screening, and molecular docking studies" pptx

... methods are gener- ally divided into ligand-based virtual screening and structure-based virtual screening. Pharmacophore- based database searching is considered a type of ligand-based virtual screening, ... 268:17083-17095. 18. Barak D, Kronman C, Ordentlich A, Ariel N, Bromberg A, Marcus D, Lazar A, Velan B, Shafferman A: Acetylcholinesterase peripheral anionic site deg...

Ngày tải lên: 10/08/2014, 05:21

... (RA and SpA); MRI of wrists and fingers 8 1.5 Savnik [28] 2002 3 Patients with inflammatory arthritis (RA and SpA); MRI of wrists and fingers, Not stated 0.2 and at baseline and after 1 year ... Medicine and Health Sciences, University of Auckland, Auckland, New Zealand 2 Department of Rheumatology, St George Hospital, University of New South Wales, New South Wales, A...

Ngày tải lên: 09/08/2014, 07:20

... use and by what route. Cancer-related bone pain is a particularly difficult symptom to treat. Bisphosphonates have gained acceptance as a standard approach to bone pain in adults. In the idealized ... shock sensations, nor was there hyperalgesia or allodynia. Pain was assessed by verbal self-report as he did not want to use any of the standardized childhood pain scales, and by the n...

Ngày tải lên: 11/08/2014, 10:22

... Kawakami N, Okamura N, Kodama H, Yamaguchi T, Hayakawa T, Nunomura A, Chiba S, Perry G, Smith MA, Fujimoto S: Activation of NADPH oxidase in Alzheimer's dis- ease brains. Biochem Biophys ... DE, Karlo JC, Cannady SB, Landreth GE: Inflam- matory mechanisms in Alzheimer's disease: inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARgamma ago...

Ngày tải lên: 19/06/2014, 22:20

... Dewar GA, Griffin SM, van Hasselt CA, et al.: Fatal haemoperitoneum due to liver metastases from nasopharyngeal cancer. Aust N Z J of Surg 1991, 61(9):723-725. 6. Yoshida H, Mamada Y, Taniai ... hepatic metastases from an unknown primary was identified promptly with computed tomography imaging and was subsequently managed conservatively. Conclusions: This case aims to convey key teach...

Ngày tải lên: 11/08/2014, 12:20

... Tohru Nakanishi 1 , Takashi Nishida 1,3 , Takako Hattori 1 , Teruko Takano-Yamamoto 2 and Masaharu Takigawa 1,3 1 Department of Biochemistry and Molecular Dentistry, and 2 Department of Orthodontics, ... Orthodontics, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan; 3 Biodental Research Center, Okayama University Dental School, Japan Connective tis...

Ngày tải lên: 24/03/2014, 04:21

... detected using antibodies against Iba-1 (Abcam, Cambridge, UK) to detect activated microglia and ICAM-1 (Abcam) Binding was detected using a biotinylated secondary antibody and an ABC standard kit (Vector ... stated that MS lesions localize in a random fashion, more care- ful analysis rev eals a distinct symmetry when small pla- ques and all demyelinating activity are taken into a...

Ngày tải lên: 19/06/2014, 22:20

... coenzyme A (HMG-CoA) reduc- tase enzyme. These include naturally occurring lovastatin, chemically modified simvastatin and pravastatin [1–3] and the synthetically derived atorvastatin, fluvastatin and cerivastatin. ... Comparison, structure and organization of bone and other mineralized tissues and the mechanism of calcifi- cation. In: Handbook of physiology, endocrinology...

Ngày tải lên: 09/08/2014, 03:24

... primed and expanded with TGF-β have the potential to be used as a therapy for patients with systemic lupus erythematosus and other chronic inflammatory diseases. This novel adoptive immunotherapy also ... large numbers, and raises the possibility that the transfer of these cells back to the donor Commentary The potential of human regulatory T cells generated ex vivo as a tr...

Ngày tải lên: 09/08/2014, 03:24

... factor controlled by two principal signaling cascades, each activated by a set of signal ligands: the classical/canonical NF-κB activation pathway and the alternative/noncanonical pathway. The former pathway ... pathways are termed the ‘classical’ or ‘canonical’ pathway and the ‘alternative’ or ‘noncanonical’ pathway. The classical nuclear factor- κκ B pathway In the classical or cano...

Ngày tải lên: 09/08/2014, 10:23