Báo cáo y học: "Protein kinases modulate store-operated channels in pulmonary artery smooth muscle cells" doc

... pulmonary arteries [17,18]. Activation of SOCs in pulmonary artery myocytes is regulated by PKG and PKA The guanyl ate cyclase-cyclic GMP-protein kinase G sig- naling pathway plays a pivotal role in ... activated by protein kinase C in vascular myocytes. J Physiol 2008, 586:2463-2476. 9. Ng LC, Gurney AM: Store-operated channels mediate Ca 2+ influx and contraction in rat p...

Ngày tải lên: 10/08/2014, 05:21

... Patients with hyperhom- ocysteinemia have homocysteine levels in the 0.1–0.25 m M range. In these studies, homocysteine was found to elicit a dose-dependent increase in toxicity in VSMC. In the presence ... on plastic alone, indicating that cell–substrate adhesion may be important in maintaining cell viability. Ab also caused an increase in the number of apoptotic cells. This in...

Ngày tải lên: 22/02/2014, 07:20

... N 1 ,N 11 - diethylnorspermine (DENSPM) which induces a rapid depletion o f all polyamines by downregulating the activity of the biosynthetic e nzymes and upregulating the activity of the catabolic enzyme ... etabolic pathway, the induction of SSAT results in the acetylation of spermine and spermidine, which are subsequently oxidized by polyamine oxidase to form spermidine and putrescine, r...

Ngày tải lên: 17/03/2014, 23:20

... predominance. 3 EPP is caused by a def iciency of ferrochelatase, the final enzyme in heme synthesis, which leads to an accumula- tion of pr otoporphyrin in various tissues, includ- ing the skin ... edema and erythema of the extrem- ities and hepatomegaly. Laboratory evaluation included elevated liver transaminases and plasma pro- toporphyrin, with normal urine porphyrins. Liver biopsy co...

Ngày tải lên: 08/08/2014, 21:20

... to sustain their caring role. In the comprehensive Cochrane review of family interven- tions for schizophrenia that was updated in 2006, there was no study of family psychoeducational intervention from ... maximum interaction with the patient or who was directly involved with the patient was included in the study. Mostly these were parents, spouses, siblings or any other significant rel...

Ngày tải lên: 08/08/2014, 23:21

... B-cell-attracting chemokine; IL, interleukin; IP, interferon inducible protein; MCP, monocyte chemotactic protein; MIG, monokine induced by gamma-interferon; MIP, macrophage inflammatory protein; SCYA, ... immunoglobulin G; IL = interleukin; LIF = leukemia inhibitory factor; LPS = lipopolysaccharide; MCP-1 = monocyte chemotactic protein-1; MIP = macrophage inflammatory protein; MOI = multip...

Ngày tải lên: 09/08/2014, 10:20

... parental genotype calls A quick scan of the genotype inheritance revealed many double crossovers within small DNA segments that were likely genotype calling errors in the progeny, particularly when ... reduced recombination [5,6]. Many factors can influ- ence estimates of RR (or more precisely outcrossing rate), including the intensity of transmission by mosqui- toes, diversity o f local pa...

Ngày tải lên: 09/08/2014, 22:24

... biospy? Respiratory Medicine 2010;104:S81eS85. 2. Sundar KM, Gosselin MV, Chung HL, Cahill BC. Pulmonary Langerhans Cell Histiocytosis: Emerging Concepts in Pathobiology, Radiology, and Clinical ... ribosylation factor-like protein 3 and annexin A3 (ANXA3)), proteins involved in ion transport (such as serotransferrin (TRFE) and hemoglobin subunit beta) and several inflammatory prote...

Ngày tải lên: 10/08/2014, 09:22

... related to Maffucci syndrome in a man: a case report Takeshi Kondo Abstract Introduction: Maffucci syndrome is a rare clinical entity (app roximately 200 cases have been reported in the medical literature) ... Maffucci syndrome, focusing on the pathologic nature of the submitted tissue, is reported. Introduction Maffucci syndrome is a rare clinical entity (approxi- mately 200 cases have b...

Ngày tải lên: 10/08/2014, 23:21

... the cytokines are used, allow- ing high sensitivity. Specificity of the assay has been con- trolled by the manufacturer by excluding cross reactivity towards 25 other cytokines, including growth ... Gender influences clinical presentations and markers in inflammatory diseases. In many chronic conditions, frequency of complications is greater in females, suggesting that continuous infla...

Ngày tải lên: 11/08/2014, 03:20