Báo cáo y học: "Three novel beta-galactosidase gene mutations in Han Chinese patients with GM1 gangliosidosis are correlated with disease severity" ppsx

... mutations in the intact tissue (synoviocytes in the intimal lining) represent only about 20% of the total compared with 100% of the cells in the homogeneous cell cultures. Our data are consistent with ... FLS with regard to the number or types of p53 mutations. The mutations in very late stage of disease are therefore equally abundant in all regions of the rheuma- t...

Ngày tải lên: 09/08/2014, 06:22

... example, chondrocytes are known to upregulate the production of their own pro-inflammatory cytokines, including IL-1β and tumor necrosis factor-α, under the influence of proinflammatory cytokines present in ... than those cur- Figure 5 Gene expression pattern of chondrocytes after in vivo inoculation in scaffoldsGene expression pattern of chondrocytes after in vivo inoculation in...

Ngày tải lên: 09/08/2014, 10:20

... region encoded by a frameshift in exon 5 contains an elastin/laminin-binding domain (underlined). The 3 bp in- frame deletion resulting in p.S95del is enclosed within a square. Yang et al. Journal ... are caused by defects in the elastin-bind- ing domain of EBP. Abbreviations GM1: GM1 gangliosidosis; GLB1: beta-galactosidases; EBP: elastin binding protein; PPCA: protective protei...

Ngày tải lên: 10/08/2014, 05:21

... clustering approach to identify additional genes that are coexpressed with the most significantly differentially expressed genes. Array data can be internally validated by, for example, car- rying ... sampling of those gene pathways that are activated and relatively disease specific. Conclusion Since the dramatic illustration of the clinical utility of microarray technology in pa...

Ngày tải lên: 09/08/2014, 01:23

... 'sympathetically maintained pain' [5]. Naturally occurring sympathetic neurotransmitters are cate- cholamines known as norepinephrine, epinephrine, and dopamine. All three substances act within the ... inhibition in rats results in a dramatic increase in sensitivity to pain. Low COMT activity may increase pain sensitivity by activating beta (2/3)-adrenergic receptors. The ob...

Ngày tải lên: 09/08/2014, 10:21

... NP region. Molecular changes in degenera- tion include altered matrix synthesis, including a decrease in glycosaminoglycan production and an increase in collagen type I within the NP, and upregulation ... matrix-degrading enzymes [2-5]. This results in an increase in matrix destruction, ADAM-TS: a disintegrin and metalloproteinase with thrombospondin motif; AF: annulus fibrosus; G...

Ngày tải lên: 09/08/2014, 14:20

... particularly during TT procedure; thus, in many clinics, trocar technique is no longer used [4-7]. In this method, application of drain without finger explora- tion can cause pulmonary parenchymal injuries ... drain in the pleural space. Although TM usually occurs in urgent TT procedures, it may also be associated with the method of TT used. In a study where TM was defined in fi...

Ngày tải lên: 10/08/2014, 10:20

... physically restrained than younger patients. Additionally, they found that the dominant rationale for the use of restraints in this population was patients disrupting their own treat- ment, rather than prevention ... approximately 10 minutes to administer. In the current study the caregiver was a mem- ber of the nursing staff caring for the patient during the first two days of hospital...

Ngày tải lên: 08/08/2014, 20:23

... produced by resting synoviocytes. Accordingly, the predictive value of changes in IL-6 was better than that of OPG. Our find- ings extended previous studies indicating a correction in high OPG ... (TNF) bioactivity in rheuma- toid arthritis (RA) patients and healthy individuals. Using the ability of TNF-α to stimulate RA synoviocytes, TNF-α (5 ng/ml) was combined with increasing co...

Ngày tải lên: 09/08/2014, 06:22

... normal controls and subjects with fibromyalgia syndrome. Pain 2003, 102:87-95. 44. Martinez-Lavin M: Fibromyalgia as a sympathetically main- tained pain syndrome. Curr Pain Headache Rep 2004, 8:385-389. 45. ... muscle reactivity in back pain patients following a psychological stress induction. Johannes and colleagues [32] found greater BP reactivity in patients with hypertension c...

Ngày tải lên: 09/08/2014, 07:20