... human M cells [5], Langerhans cells, and interdigitating reti-culum cells [4]. However, fundamental information onthe biosynthesis, processing, and intracellular traffick-ing of this protein ... chains of ratcathepsin E in the transfected cells and then assessedthe role of N-glycosylation in its folding, processing,maturation, and subcellular trafficking. HEK-293Tcells expressing wild-type ... compartment.Interestingly, the intracellular localization of recom-binant cathepsin E appears to vary with the cell typeused. In mouse L cell and monkey Cos 1 cells, theexpressed human cathepsin E...