Fibronectin and laminin promote differentiation of human mesenchymal stem cells into insulin producing cells through activating Akt and ERK pptx
Fibronectin and laminin promote differentiation of human mesenchymal stem cells into insulin producing cells through activating Akt and ERK pptx
... RESEA R C H Open Access Fibronectin and laminin promote differentiation of human mesenchymal stem cells into insulin producing cells through activating Akt and ERK Hsiao-Yun Lin1,2†, Chih-Chien ... phosphorylation status of Akt and ERK for stage III cells. There was a baseline of Akt and ERK phosphorylation without adding ECM. FN and LAM increased phosphorylation of Akt and ERK, and LAM had greater ... of human mesenchymal stem cells into insulin producing cells through activating Akt and ERK. Journal of BiomedicalScience 2010 17:56.Submit your next manuscript to BioMed Central and take full...
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Báo cáo y học: "Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer" pps
... chondrogenic differentiation of mesenchymal progenitor cells and to up regulate the levels of type II collagen and aggrecan in chondrocytes and chondro-progenitor cells [1,7-11]. During development of ... cultured human mesenchymal stem cells from marrow. Tissue Eng 1998,4:415-428.35. Mueller MB, Tuan RS: Functional characterization of hypertro-phy in chondrogenesis of human mesenchymal stem cells. Arthritis ... otherBMPs, BMP-2 and BMP-7 are known to induce differentiation of mesenchymal progenitor cells and preosteoblasts into mature osteoblasts, and to enhance the differentiated function of osteoblasts,...
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Overexpression of hTERT increases stem-like properties and decreases spontaneous differentiation in human mesenchymal stem cell lines ppt
... loss of stem- like properties and spontaneous differentiation those hinder the expansion and applica-tion of human mesenchymal stem cells (hMSCs), we have clonally isolated permanent and stable human ... RT-PCR analysis of expression levels of hTERT and GAPDH, and (B) Real-time RT-PCR analysis of expression levels of DNMT1, DNMT3A and DNMT3B in primary human mesenchymal stem cells transfected ... expression profile of the cells converged toward embryonic stem cells. These data demonstrate these cells not only are a useful toolfor the studies of cell differentiation both for the mesenchymal and...
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Báo cáo y học: "Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells" pdf
... theosteogenic differentiation of human mesenchymal stem cells (MSCs); and blockade of the activity of the BMP inhibitorincreases the rate of osteogenic differentiation of human MSCsin vitro.Methods Human ... day 10 and by Ali-zarin Red stain at day 21.Figure 2Expression of BMP-2 and chordin transcripts during osteogenic differ-entiation of human mesenchymal stem cellsExpression of BMP-2 and chordin ... differ-entiation of human mesenchymal stem cells. (a) Temporal progression of bone morphogenetic protein (BMP)-2 and chordin expression during osteogenic differentiation of human MSCs over a...
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báo cáo hóa học:" MicroRNA and gene expression patterns in the differentiation of human embryonic stem cells" doc
... between EB and hES cells and betweenEB and adult cells were significant (P < 0.05). The differ-ence in expression of miR-17-5p between EB and hES cells, and of miR-20a between EB and adult cells ... hES cells than ineither EB or adult cells (Figure 6, panel A). The differencein the expression of miR-200c, miR-302b, and miR-367between hES cells and EB, and between hES cells and adult cells ... expression of miR-92 has been reported in human embryonic stem (ES) cells [16,26], mouse ES cells[ 20] orSequence and GO analysis of the miR-302 cluster and miR-520 clusterFigure 8Sequence and GO...
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Báo cáo khoa học: A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells doc
... specific features of the plasticity of adult stem cells are largelyunknown. Recently, we demonstrated the hepatic differentiation of human adipose tissue-derived mesenchymal stem cells (AT-MSCs). ... compilation ª 2008 FEBSA comparative analysis of the transcriptome and signalpathways in hepatic differentiation of human adipose mesenchymal stem cells Yusuke Yamamoto1,2,*, Agnieszka Banas1,*, ... IH, Park HK, Han H & Kim H (2005) Invitro differentiation of human umbilical cordblood-derived mesenchymal stem cells into hepatocyte-like cells. Biochem Biophys Res Commun 330, 1153–1161.13...
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Báo cáo Y học: Interaction between p21-activated protein kinase and Rac during differentiation of HL-60 human promyelocytic leukemia cell induced by all-trans-retinoic acid pdf
... generatingactivity of HL-60 Cells Utilizing the induced differentiation of HL-60 promyelo-cytic leukemia cells as a model of myeloid maturation, weexamined the expression and location of Rac and PAK.The ... revealed that Rac and PAK isoformsincreased in both cytosol and membrane fractions uponthe induced differentiation of HL-60 cells. No remarkableRacwasseenintheplasmamembranefractionofundifferentiated ... theinduced differentiation of HL-60 into granulocytes (datanot shown).DISCUSSIONPAK is a member of the serine/threonine kinase family,which includes three types of isoform, PAK68, PAK65 and PAK62....
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Báo cáo y học: "Biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation" potx
... the context of self-renewal and regulation of lineage-specific differentiation of mesenchymal stem cells. In addition wereview recent research on the concept of stem cell niche, and itsrelevance ... Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy. J Cell Mol Med 2004, 8:301-316.31. Tuan RS, Boland G, Tuli R: Adult mesenchymal stem cells ... 2004, 16:681-687.19. Boland GM, Perkins G, Hall DJ, Tuan RS: Wnt 3a promotes pro-liferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J Cell Biochem 2004,...
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Báo cáo y học: "Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions" pdf
... triggers differentiation of HUMSCs into cardiomyocytes and maturation of HUMSCs derived cardiomyocytes.Admittedly, the detailed mechanism(s) of above effects of S1P on differentiation of and maturation ... Sphingosine-1-phosphate promotes the differentiation of human umbilical cord mesenchymal stem cells into cardiomyocytes under the designated culturing conditions. Journal of Biomedical Science ... multi-potency of different human stem cells. Our investigationindicates that S1P promotes differentiation of HUMSCstowards cardiomyocytes and functionally maturation of hUC-MSCs derived cardiomyocytes,...
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Tài liệu Báo cáo khoa học: Two novel variants of human medium chain acyl-CoA dehydrogenase (MCAD) K364R, a folding mutation, and R256T, a catalytic-site mutation resulting in a well-folded but totally inactive protein pptx
... those foreach of the MCAD mutants, K364R and R256T, and for the wild-type enzyme, in E. coli cells grown both at31 °C and 37 °C, and the effect on activity (ferri-cenium assay), and tetramer ... affectmainly the initial folding and stability of the tetramer, and similarly lowered levels of tetramer in human cells would account for the observed elevation of indicatoracyl-carnitine levels.From ... Purifi-cation and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases fromrat liver mitochondria: isolation of the holo- and apoenzymes and conversion of the apoenzyme...
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