Involvement of p63 in the herpes simplex virus-1-induced demise of corneal cells Research ppt

... replication To investigate the basis of the HSV-1-induced increase of the TAp63γ level, SIRC cells were infected in the presence or absence of the viral DNA replication inhibitor ACG. The cells were ... reveal that the 68 kDa p63 protein detected in the mock-infected SIRC cells is ΔNp63α, while the 51-62 kDa p63 isoform detected in HSV-1-infected cultu...

Ngày tải lên: 10/08/2014, 05:21

... critical step in bringing them to the clinical setting. Future stud- ies should focus on the quantification of the effect of these correctors on the NBD1–Hsc70 interaction in the presence of other relevant ... remains plausible that the F508del-induced exposure of Hsc70-binding sites on NBD1 diminishes the ability of ATP binding to stabilize this domain against its...

Ngày tải lên: 23/03/2014, 05:22

... contrib- uted in the analysis and interpretation of the data, partic- ipated in the design of the models proposed and in the drafting and revision of the manuscript. All authors read and approved the final ... (figure 1). In anticipation of the difficulties expected in manipulating the left end hairpin and to increase the chances of obtaining the desi...

Ngày tải lên: 19/06/2014, 08:20

... capable of acting as an origin of replica- tion, lacks the arrangement of the specific domains present in the dimer duplex intermediate of MVM, the only active form of the left hairpin described ... (figure 1). In anticipation of the difficulties expected in manipulating the left end hairpin and to increase the chances of obtaining the desired construct t...

Ngày tải lên: 20/06/2014, 04:20

... Fine mapping of mutations in the fusion-inducing MP strain of herpes simplex virus type 1. Virology 1984, 136(1):100-109. 19. Ryechan WT, Morse LS, Knipe DM, Roizman B: Molecular genetics of herpes ... U, Hoflack B: A tyrosine-based motif and a casein kinase II phosphorylation site regulate the intracellu- lar trafficking of the varicella-zoster virus glycoprotein I, a p...

Ngày tải lên: 18/06/2014, 18:20

... biosynthesis of natural poly- amines (putrescine, spermidine and spermine) through conversion of l-arginine into l-ornithine [16]. The lat- ter is in turn used by ODC to produce putrescine, the precursor ... the precursor of spermidine and spermine. To further ana- lyze the regulation of the polyamine-synthetic pathway in virus infection, ODC expression in SeV-infected...

Ngày tải lên: 07/03/2014, 21:20

... because of the attachment of the hexahistidine, the recombinant PpTGase protein appeared to be slightly larger. These results indicate that the cDNA obtained covered the entire coding region. Involvement ... 3459 terminus that is required for binding to the plasma membrane, thereby being involved in the formation of the corneum [47]. Additional amino-terminal residue...

Ngày tải lên: 17/03/2014, 23:20

... strengthening of circulat- ing T cells to VCAM-1 on endothelial cells. Postulating the involvement of chemokines in the integrin-mediated arrest of autoreactive T cells at the BBB, the investigators [3] ... mononuclear cells in the perivascu- lar space during the recovery phase of an acute event, and may therefore be involved in the regulation of recover...

Ngày tải lên: 19/06/2014, 22:20

... up-regulated in proliferative cells, including several cancer cell lines, and induces apoptosis by interacting with many kinds of materials [21], includ- ing viral protein (Vpr of HIV-1 and pBI-F2 of influenza virus) ... shows profiles of the immunoprecip- itates containing MEF-UL7 and its binding proteins in a denaturing gel. Several bands that were detected in immu- noprec...

Ngày tải lên: 20/06/2014, 01:20