Combinatorial gene therapy renders increased survival in cirrhotic rats pptx

... distribution, and repro- duction in any medium, provided the original work is properly cited. Research Combinatorial gene therapy renders increased survival in cirrhotic rats Francisco J Gálvez-Gastélum 1 , ... therapeutically gene therapy. D, Survival analysis (Kaplan Meier) of cirrhotic animals in each experimental group. Increment of survival (60 days) in t...

Ngày tải lên: 10/08/2014, 05:21

... These surprising findings suggest that TCF4 might be the main binding partner for b-catenin during development and progression of colorectal cancer whereas an enhancement of Wnt/b- catenin transcriptional ... o r negative in tumour cells, while the intensity of staining was not considered. To determine the combined influence of LEF-1 and TCF4 on tumorigenesis, a LEF-1/TCF4 score was generat...

Ngày tải lên: 18/06/2014, 16:20

... with better survival outcomes. We found that the SGA provides useful prognostic informa- tion in patients with ovarian cancer. In a clinical setting, the SGA is invaluable in identifying malnourished patients ... SGA was made in this study. This bias, however, was minimized by restricting the use of the SGA to well-trained dietitians with an expertise in the use of this clinical i...

Ngày tải lên: 20/06/2014, 07:20

... establishment of the marginal zone [8]. In general, TNF and soluble LTα are thought to have overlapping roles in this setting, although LTα may play a predominant role in promoting the formation of ... these cells in the inflamed synovia and that blocking the effects of TNF decreases trafficking into and retention of B cells in the synovia, thereby increasing their proportion in t...

Ngày tải lên: 09/08/2014, 14:22

... in ligature-induced periodonti- tis, a finding that corroborates with the study of Lohinai et al [30]. It implies that venlafaxine lacks efficacy in sup- pressing EPD-associated increase in iNOS ... clinical findings. Nervenarzt 2007, 78:31-38. 16. Piacentini MF, Clinckers R, Meeusen R, Sarre S, Ebinger G, Michotte Y: Effects of venlafaxine on extracellular 5-HT, dopamine and noradren...

Ngày tải lên: 11/08/2014, 07:21

... efficiency of target suicide gene therapy mediated by hTE RT promoter in combina- tion with immuno -gene therapy in a murine m odel of LLC both in vitro and in vivo. Figure 5 In vivo toxicity studies. ... (Shanghai, China) and maintained in 5% CO 2 at 37°C in Dulbecco’s minimum essential medium (DMEM) containing 10% fetal bovine serum (FBS), 100 U/m l penicillin and 100 m...

Ngày tải lên: 18/06/2014, 19:20

... (Shanghai, China) and maintained in 5% CO 2 at 37°C in Dulbecco’s minimum essential medium (DMEM) containing 10% fetal bovine serum (FBS), 100 U/m l penicillin and 100 mg/ml strepto mycin. All culture ... efficiency of target suicide gene therapy mediated by hTE RT promoter in combina- tion with immuno -gene therapy in a murine m odel of LLC both in vitro and in vivo. Figur...

Ngày tải lên: 20/06/2014, 03:20

... proviral form of the vector is shown in Fig. 1. The packaging system contains the self-inactivating transducing constructs (sin) obtained after a 400-bp deletion including the enhancer and promoter from ... of co-incubated, untransduced cells. Len- tiviral vectors have been shown to effectively transduce genes into a range of both dividing and nondividing cell types, including neurons, reti...

Ngày tải lên: 24/03/2014, 04:21

... that would support a presumption in favor of continuing the development of germline genetic engineering. That is, we have argued that germline genetic engineering is not intrinsically morally objectionable. ... germline genetic engineering. That sort of therapy is aimed at addressing genetic disorders, not simply in the genome of the individual who is genetically altered but in the de...

Ngày tải lên: 10/04/2014, 22:10

... promotor, resulting in tat- independent transcription. The self-inactivating vector was constructed by deleting 133 bp in the U3 region of the 3¢ LTR including the TATA box and the binding sites for ... deleting retroviral genes and adding gene( s) of interest. Vectors can be produced in pack- aging cell lines that express packaging genes. The major advantage of retroviral vectors is t...

Ngày tải lên: 10/04/2014, 22:11