Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin inhibits the proliferation of ARPE-19 cells ppt
Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin inhibits the proliferation of ARPE-19 cells ppt
... activity of at least one member of the pathway [17,18]. All of these pathways may be involved in the proliferation of RPE cells, and inhibiting one of these pathways leads to the apoptosis of RPE cells ... 15 Results 17-AAG inhibited proliferatin of RPE cells To study the biological effect of the inhibition of Hsp90 in ARPE-19 cells, the cells were...
Ngày tải lên: 10/08/2014, 05:21
Báo cáo khoa học: Hexadecylphosphocholine inhibits phosphatidylcholine biosynthesis and the proliferation of HepG2 cells pot
... biosynthesis of PC in HepG2 cells at the level of CT activity. It interferes with the translocation process of CT from the cytosol to the membrane and finally leads to an inhibition of the biosynthesis ... interference of HePC on this regulatory process. Thence, HePC could act on CT activity either by promoting the release of the enzyme from the membrane to the...
Ngày tải lên: 17/03/2014, 11:20
Báo cáo khoa học: Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells pptx
... acid letter code) at their C-termini. In the ER, the presence of a higher pH allows detachment of the retrieved protein from the KDEL receptors [4]. The REDLK Keywords anticancer therapy; bacterial ... culture medium) of the recom- binant polypeptides (ATF–SAP chimeras from the 72 h con- ditioned medium of protected oocytes, see below). At the end of the exposure p...
Ngày tải lên: 23/03/2014, 15:21
Báo cáo khoa học: Dehydroepiandrosterone inhibits the proliferation and induces the death of HPV-positive and HPV-negative cervical cancer cells through an androgen- and estrogen-receptor independent mechanism pptx
... and it is the second most common cause of death from can- cer among Mexican women [21]. Therefore, the aim of this work was to evaluate the effect of pharmacological doses of DHEA on the proliferation ... the malignant state of the cells. HeLa cells are an advanced-stage cervical cell carcinoma [27], in comparison with the other cell lines used for which no stage...
Ngày tải lên: 16/03/2014, 00:20
Báo cáo khoa học: Glucagon-like peptide-2 stimulates the proliferation of cultured rat astrocytes pptx
... of GLP-2 (1 l M ) and fetal bovine serum (10%) on the percentage of cells present in each phase of the cell cycle in comparison with the control cells. The decrease in the number of cell in the ... as the percentage of hypodiploid cells with respect to total cells [31] and the stage of the cell cycle as the percentage of cells in G0/G1 (diploid cell...
Ngày tải lên: 17/03/2014, 03:20
Báo cáo khoa học: Cupiennin 1a, an antimicrobial peptide from the venom of the neotropical wandering spider Cupiennius salei, also inhibits the formation of nitric oxide by neuronal nitric oxide synthase pptx
... domain of nNOS. CaM is not only essential for the operation of nNOS and the other NOS isoforms, but is also the regulatory protein for a variety of other enzymes, including kinases [27–29]. Two ... Ca 2+ -CaM when it binds to the CaM-binding domain of endothelial nitric oxide synthase (eNOS) [33]. The second example is when the C-terminal lobe of Ca 2+ -CaM binds part o...
Ngày tải lên: 23/03/2014, 09:21
Báo cáo khóa học: The proteasome inhibitor, MG132, promotes the reprogramming of translation in C2C12 myoblasts and facilitates the association of hsp25 with the eIF4F complex pptx
... ole in the migration of endothelial cells and i n recovery of cells from wounding [40]. In a variety of cells, in a ddition to the induction of hsp25 and aB-crystallin expression, inhibition of the ... investigation into the regulation of protein synthesis in mammalian cells, we have investigated the e ffects of inhibition of the p roteasome o n the localiz...
Ngày tải lên: 23/03/2014, 12:20
Báo cáo khoa học: The myostatin-induced E3 ubiquitin ligase RNF13 negatively regulates the proliferation of chicken myoblasts pot
... for the understanding of both the mechanism of action of RNF13 and the myostatin signaling pathway during muscle growth, as well as for the possible clarification of the function of RNF13 in other ... overexpres- sion of RNF13 inhibited the proliferation of CFMs with a corresponding decrease in the expression of two repre- sentative myogenic genes, MyoD and Cave...
Ngày tải lên: 29/03/2014, 08:20
Báo cáo khoa học: A Kazal prolyl endopeptidase inhibitor isolated from the skin of Phyllomedusa sauvagii pdf
... two variants of a new protein isolated from the skin of the anuran, P. sauvagii, whose sequence indicates membership of the Kazal family. Most members of this family are small protein inhibitors of serine ... clearly pertain to the serine protease inhibitor type of Kazal proteins. In particular, PSKP-1 is 48% identical to the inhibitor of acrosin – the major prot...
Ngày tải lên: 30/03/2014, 13:20
báo cáo hóa học: " Ginkgolide B inhibits the neurotoxicity of prions or amyloid-β1-42" pdf
... scrapie [21] and AD [22]. The presence of ginkgolides greatly reduced the activation of apoptotic pathways in these cells. The presence of ginkgolides also reduced microglial killing of neurons damaged ... amyloid-β 1-42 [15]. These results are com- patible with epidemiological data that show that the use of COX inhibitors reduces the onset and severity of AD [28]. In...
Ngày tải lên: 19/06/2014, 22:20