Akt regulates the expression of MafK, synaptotagmin I, and syntenin-1, which play roles in neuronal function docx

... Akt inhibitor. Taken together, these results indicate that Akt downregulates the expression of MafK, SytI, and Syn-1. MafK and SytI are involved in certain aspects of neuronal function. Inhibition ... pharmacologi- cal inhibition of Akt causes an increase in the expression of these genes in PC12 (WT -Akt) cells. Therefore, it is alleged that Akt downregu...

Ngày tải lên: 10/08/2014, 05:21

... the local market structure in which the mergers take place. The variable HERF is the weighted average of the Herfindahl indices of the merging firms across the local deposit markets in which ... improve. Another potential explanation of the increase in measured profit efficiency from megamergers may be the specification of the profit finction....

Ngày tải lên: 06/03/2014, 08:21

... was absent in cells with a functional inactive HIF or lacking the HIF-1a protein in general. In fact, for the P4ha1I the involvement of HIF in the activation of gene expression during hypoxia ... addressed this issue therefore by investi- gating the in uence of the UPR for the expression of the procollagen hydroxylases. With the exception of PDI, whic...

Ngày tải lên: 20/02/2014, 02:21

... HT22 cells, to further examine the binding of Nrl to the Ppp2r5c promoter in vivo. Nrl binding to the Ppp2r5c and rhodopsin promoters was examined by quantitative real-time of ChIP samples with ... binding of Nrl to the rhodopsin promoter (Fig. 4C,D). The mRNA tran- script levels of Ppp2r5c and rhodopsin in mouse retina corresponded to the observed increase in Nr...

Ngày tải lên: 06/03/2014, 02:20

... that the mecha- nism underlying the recognition of protein quality acts through the sensing of free circulating amino acids resulting from the intestinal digestion of proteins [4,5]. Another ... contribute to these multistep processes, including the metabolic conditions of the cell, nature of the stimulus, RNA binding factors and the sequence of the target mRNA...

Ngày tải lên: 07/03/2014, 03:20

... groups; most of them form an homodimer and each subunit binds a copper and zinc ion [12]. In plants, Cu,Zn- SODs are mainly located in the cytosol and in the chloroplast stroma, although other locations ... downstream of SA, since SA-treated * Corresponding author: tavares@bio.uminho.pt Maritime pine chl Cu,Zn-SOD expression 849 The amino acid sequence of the corre...

Ngày tải lên: 08/08/2014, 01:22

... partic- ipated in the design and coordination of the study. GF conceived of the study, and participated in the design of the study and supervised the project. All authors read and approved the final manuscript. Acknowledgements This ... Lipopolysaccharide. Competing interests The authors declare that they have no competing interests. Authors' contributio...

Ngày tải lên: 11/08/2014, 08:22

... showing an age-related increase in OCN gene expression in OA and a decrease in controls [16]. This finding is supportive of an increase or main- tenance of bone volume in OA individuals versus the ... thick, were stained by the von Kossa silver method and counterstained with haematoxylin and eosin to distinguish between the mineralised bone, the osteoid, and the...

Ngày tải lên: 09/08/2014, 08:23

... investigated in PBMC and THP-1 cells. As shown in Fig. 1C,D, oxLDL decreased the expression levels of SR-BI, and HDL 3 increased the levels of SR-BI. KLF4 in uences the expression of SR-BI in PMA-differentiated ... adhesion to the endothelial surface and prolongation of clotting time following the induc- tion of KLF4 under in ammatory states, and implic...

Ngày tải lên: 18/02/2014, 04:20

... biosynthesis [28,29]. Moreover, the site of action of these two proteins is the rate-limiting step in steroidogenesis [6]. Fatty acyl-CoAs bind to the acyl-CoA-binding protein, which can bind and ... regulation of the rate-limiting step in steroidogenesis through the release of AA [12]. Consid- ering the crucial role of StAR in that step and given the fact...

Ngày tải lên: 16/03/2014, 18:20