Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients potx

... provided the original work is properly cited.Research Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dyslipidemia patients Chyi-Huey ... 10.1186/1423-0127-17-12Cite this article as: Bai et al., Shorter GT repeat polymorphism in the heme oxygenase-1 gene promoter has protective effect on ischemic stroke in dys-lipidemia patients Journal of Biomedical ... levels. The find-ings suggest that genetic characteristics of the HO-1 gene may interact with the oxidative stress conditions to contrib-ute to the development of ischemic stroke. These findingsshould...

GT-repeat polymorphism in the heme oxygenase1 gene promoter and the risk of carotid atherosclerosis related to arsenic exposure ppt

... leukocytes in the buffy coat using the Puregene DNA isolation kit (GentraSyst em, Minneapolis, MN, USA). The 5′-flanking regioncontaining the (GT) n repeats of the HO-1 gene wasamplified by the polymerase ... asignificant or borderline level were include d in furtheranalyses.HO-1 GT repeat polymorphism and the carotidatherosclerosis index The number of GT repeats in the HO-1 gene promoter of the participants ... primarily controlled at the levelof transcription initiatio n. The 5′ -flanking region con-tains varying lengths of GT repeats 526 bp upstream of the transcription site [14]. The number of GT repeats, (GT) n,...

Báo cáo Y học: Nuclear proteins that bind to metal response element a (MREa) in the Wilson disease gene promoter are Ku autoantigens and the Ku-80 subunit is necessary for basal transcription of the WD gene ppt

... promoter activity in HepG2 cells The relative positions of the MREs within the promoter region of the WD gene are indicated in Fig. 1. The fourMREs are located in the proximal region of the WD gene promoter ... to the Ku proteins. The effects of RNAi of the Ku-80 subunit and the truncated Ku-80 mutant on WD gene expressionTo examine the effects of the Ku protein on the regulationof WD gene expression, ... MREe in the forward orientation, and MREc and MREd in reverse orientation. The effects of the mutiple MREs on promoter activity of the MT gene have been shown to be dependent on the position of the...

Báo cáo khoa học: "The incidence of recurrent flushing and its effect on branch production in Quercus petraea (Matt) Liebl growing in southern England" ppt

... relatedto the number of branches growing on the 1986 SECOND flush shoot (P ≤ 0.01) and the length of the FIRST flush in 1986 on the number of branches on the FIRSTflush ... trees in the overallmean length of all sections on the branches(table II) there was no obvious relationshipwith the proportion of sections formed by aSECOND flush.Only ... bedetermined during the previous growingseason; the lengths of FIRST and SECONDflushes reflecting, in part, different patternsof growth, physiology and apical dominance in plants...

báo cáo hóa học: " Interleukin-1 receptor 1 knockout has no effect on amyloid deposition in Tg2576 mice and does not alter efficacy following Aβ immunotherapy" pot

... responses [25]. Interleukin-1β is a key mediator ofhost response to infections and a primary cause of inflam-mation [25]. In vivo, IL-1β is elevated during infectionsand in several chronic inflammatory ... In AD and Down's syndrome, IL-1β production is increased in microglial cells in the vicinity of amyloid plaques[28,29]. Initial studies examining the association of poly-morphisms in the ... ST, Levison SW: The type 1 interleukin-1 receptor is essential for the efficientactivation of microglia and the induction of multiple proin-flammatory mediators in response to brain injury....

AN INVESTIGATION ON VOCABULARY TEACHING IN THE ADVANCED LEVEL TEXTBOOK PROGRAM FOR ENGLISH SPECIALIZED STUDENTS GRADE 11TH IN CHU VAN AN HIGH SCHOOL

... Determination strategiesOne group of determination strategies involves analyzing the unknown word, itsconstituent elements or the surrounding context to determine the meaning. Identifying the part ... thatinformation” (p.122). Current thinking seems to point toward a combination of incidental and intentionallearning. Time constraints ensure that guessing from context remains among the mostvaluable skills ... learner’s attention is on the meaning of the whole text, rather than on that particular item. Although Nation concedes thatexperiments in learning from context have only shown small gains in vocabulary...

Báo cáo khóa học: Disruption of the interaction between the Rieske iron–sulfur protein and cytochrome b in the yeast bc1 complex owing to a human disease-associated mutation within cytochrome b potx

... alteredbinding of the iron–sulfur protein on the complex. G167Ehad no major eﬀect on the interaction between the iron–sulfur protein headgroup and the quinol oxidation site, asjudged by the electron ... located within the soluble C-terminal domain on the P-side of the inner mitochondrial membrane. Thisdomain consists of residues 93–215 (using the the yeastsequence notation) and is linked by a ... interfacialprotein–protein interactions between the hinge region of ISPand the extramembranous cd2 helix of cytochrome b areimportant for maintaining the structure of the hinge regionand, by consequence, the...

Báo cáo khoa học: Post-translational modiﬁcations in the active site region of methyl-coenzyme M reductase from methanogenic and methanotrophic archaea potx

... described for the sulfuration of the C-terminal glycine in ThiS andMoaD, involved in thiamine biosynthesis and molyb-dopterin biosynthesis, respectively, and for the sulfura-tion of uridine in tRNA ... with the radicalintermediates. As the methylations provide the aminoacids with additional hydrophobic interactions,another function could be to restrict the conforma-tional ﬂexibility of the ... glycine in the peptide chain remains to beshown.Neither the functions of the ﬁve modiﬁcations norwhether the modiﬁcations are present in MCRs fromall methanogens3are known. Comparison of...

Báo cáo khoa học: Acute intermittent porphyria – impact of mutations found in the hydroxymethylbilane synthase gene on biochemical and enzymatic protein properties pdf

... (1994) Acute intermittent porphyria: identiﬁcationand expression of exonic mutations in the hydrox-ymethylbilane synthase gene. An initiation codon mis-sense mutation in the housekeeping transcript ... p.Arg116Gln in the acceptor resi-due in the ion pair, reducing their ability to formionic interaction, have previously been found in AIP patients [28,29]. The effect of the new mutationp.Glu250Asp ... HMBS indicating the positions of the mutations observed in the patients. The N-, central andC-domains are shown in silver, blue and green, respectively; the positions of the mutated amino acids...

Management in India: Grow from an Accidental to a Successful Manager in the IT & Knowledge IndustryA real-world, practical book for a professional in his journey to becoming a successful manager in IndiaRahul Goyalprofessional expertise distilled doc

... management to convey the position of the team on various issues The information processing roles are increasingly becoming more important as the amount of information and the mode of information have ... and has been changing rapidly since the Internet became part of the corporate world. In the Indian context, this role is very pronounced as the manager is the primary contact point for the ... teams in other parts of the globe. In many cases, the person on the other side (in the US, Europe, or elsewhere) never really meets or talks to anyone else but the manager of the team.Decision-making...

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