Genetic copy number variants in sib pairs both affected with schizophrenia pps

... reproduction in any medium, provided the original work is properly cited. Research Genetic copy number variants in sib pairs both affected with schizophrenia Chia-Huei Lee †1 , Chih-Min Liu †2 , ... BU678720 with a high incidence (two out of 8 pairs: 25%) of concordant loss in both sib- pairs. We analyzed the siblings for whom CNS-related CNVs were detected i...

Ngày tải lên: 10/08/2014, 05:21

... examined known copy number variants in 10 Yoruba using Agilent microarrays; and in the Wang et al. [15] study, 36 Yoruba were genotyped using Illumina BeadChips. For each Yoruba individual in ... rpm. The arrays were rinsed and filled with Wash buffer A (Affymetrix). Staining with streptavidin, R-phyco- erythrin conjugate (Invitrogen) and scanning with the GCS3000 instrument...

Ngày tải lên: 09/08/2014, 20:20

... by common copy number variants and single nucleotide polymorphisms of certain and uncertain significance in general medical practice. Genome Medicine 2010, 2:42. Beaudet Genome Medicine 2010, ... across the world, with most regulatory efforts in their infancy. e FDA has begun specifying that certain pharmacogenetic testing is desirable or perhaps mandatory prior to prescribing...

Ngày tải lên: 11/08/2014, 12:20

... genomic tiling arrays and SNP chips have become the standard technolo gy to analyze copy number varia tions in cancer genomes. Modern arra ys are inexpensive and allow for determin- ing copy number ... versa. User interface and server service The user interface of FISH Oracle is written in the Java programming language. This includes both the client side of the web application (...

Ngày tải lên: 10/08/2014, 09:22

... the predicted doubling of α-synuclein protein in blood and increased levels of the protein in the brain. erefore, even without sequence mutants, increased wild-type α-synuclein dosage may cause ... Pathogenic copy number variation in autosomal dominant Parkinson’s disease A seminal discovery in the study of PD was the report of missense mutations in the SNCA gene, encoding...

Ngày tải lên: 11/08/2014, 12:20

... pattern of electroclinical onset as either generalized (‘originating at some point from within, and rapidly engaging, bilaterally distributed networks’) or focal (‘originating within networks limited ... emerging as the most common genetic determinants for various distinct disorders with complex inheritance. ese generally include intellectual disability with or without dysmorphi...

Ngày tải lên: 11/08/2014, 12:21

... paradigm in human genetics is high frequencies of interindividual variation in the copy number (CN) of speci fic genomic DNA segments. Copy number variation (CNV) loci often contain genes engaged in ... first line of defense against intrinsic and extrinsic antigens, leading to peptide- mediated inflamm ation, opsonization leading phagocyto- sis, the direct lysis of antigens [9]....

Ngày tải lên: 10/08/2014, 10:20

... unfold in usual care. Subjects were included in the current analysis if they (a) were newly initiated on olanzapine or risperidone, defined as being free of both olanzapine and risperidone in the ... of patients with schizo- phrenia [37]. Our findings may help clinicians in choosing between olanzapine and risperidone or assist decision makers when considering the need to maintain...

Ngày tải lên: 08/08/2014, 20:23

... suggest that binge eating symptomatology may play an important role in the initi- ation and maintenance of the WG phenomenon observed in at least part of patients with schizophrenia. Finally, management ... binge eating symptomatology in patients treated with clozapine and olanzapine. J Neural Transm 2003, 110:111-121. 4. Aquila R, Emanuel M: Interventions for Weight Gain in Adul...

Ngày tải lên: 08/08/2014, 21:20

... altered in the intact brain of patients with schizophrenia. A positron emission tomog- raphy (PET) study using the selective α7 nAChR ligand [ 11 C]CHIBA-1001 [52,53] in the intact brains of patients with ... N, Kerwin R, Perry R, Perry E: Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: α-bungarotoxin and nicotine binding in the thalamus. J Neur...

Ngày tải lên: 08/08/2014, 23:21