Genetic copy number variants in sib pairs both affected with schizophrenia pps
Genetic copy number variants in sib pairs both affected with schizophrenia pps
... reproduction in any
medium, provided the original work is properly cited.
Research
Genetic copy number variants in sib pairs both
affected with schizophrenia
Chia-Huei Lee
†1
, Chih-Min Liu
†2
, ... BU678720 with a high incidence
(two out of 8 pairs: 25%) of concordant loss in both sib-
pairs. We analyzed the siblings for whom CNS-related
CNVs were detected i...
Báo cáo y học: "High resolution discovery and confirmation of copy number variants in 90 Yoruba Nigerians" pdf
... examined known copy number variants in 10
Yoruba using Agilent microarrays; and in the Wang et al. [15]
study, 36 Yoruba were genotyped using Illumina BeadChips.
For each Yoruba individual in ... rpm. The arrays were rinsed and filled with Wash
buffer A (Affymetrix). Staining with streptavidin, R-phyco-
erythrin conjugate (Invitrogen) and scanning with the
GCS3000 instrument...
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... by common copy
number variants and single nucleotide polymorphisms of certain and
uncertain significance in general medical practice. Genome Medicine 2010,
2:42.
Beaudet Genome Medicine 2010, ... across the world, with most
regulatory efforts in their infancy. e FDA has begun
specifying that certain pharmacogenetic testing is
desirable or perhaps mandatory prior to prescribing...
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... genomic tiling arrays
and SNP chips have become the standard technolo gy to
analyze copy number varia tions in cancer genomes.
Modern arra ys are inexpensive and allow for determin-
ing copy number ... versa.
User interface and server service
The user interface of FISH Oracle is written in the Java
programming language. This includes both the client
side of the web application (...
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... the predicted doubling of α-synuclein
protein in blood and increased levels of the protein in the
brain. erefore, even without sequence mutants,
increased wild-type α-synuclein dosage may cause ... Pathogenic copy number variation in autosomal
dominant Parkinson’s disease
A seminal discovery in the study of PD was the report of
missense mutations in the SNCA gene, encoding...
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... pattern of electroclinical
onset as either generalized (‘originating at some point
from within, and rapidly engaging, bilaterally distributed
networks’) or focal (‘originating within networks limited ...
emerging as the most common genetic determinants for
various distinct disorders with complex inheritance.
ese generally include intellectual disability with or
without dysmorphi...
Báo cáo y học: "Association between copy number variation of complement component C4 and Graves’ disease" ppsx
... paradigm in human genetics is high frequencies
of interindividual variation in the copy number (CN) of
speci fic genomic DNA segments. Copy number variation
(CNV) loci often contain genes engaged in ... first line of defense against
intrinsic and extrinsic antigens, leading to peptide-
mediated inflamm ation, opsonization leading phagocyto-
sis, the direct lysis of antigens [9]....
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... unfold in usual care.
Subjects were included in the current analysis if they (a)
were newly initiated on olanzapine or risperidone,
defined as being free of both olanzapine and risperidone
in the ... of patients with schizo-
phrenia [37].
Our findings may help clinicians in choosing between
olanzapine and risperidone or assist decision makers
when considering the need to maintain...
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... suggest that binge eating
symptomatology may play an important role in the initi-
ation and maintenance of the WG phenomenon observed
in at least part of patients with schizophrenia. Finally,
management ... binge eating symptomatology in patients
treated with clozapine and olanzapine. J Neural Transm 2003,
110:111-121.
4. Aquila R, Emanuel M: Interventions for Weight Gain in Adul...
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... altered in the intact brain of
patients with schizophrenia. A positron emission tomog-
raphy (PET) study using the selective α7 nAChR ligand
[
11
C]CHIBA-1001 [52,53] in the intact brains of patients
with ... N, Kerwin R, Perry
R, Perry E: Neuronal nicotinic receptors in dementia with Lewy bodies
and schizophrenia: α-bungarotoxin and nicotine binding in the
thalamus. J Neur...
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