Báo cáo y học: "Expanding access to HIV prevention" doc

... expanding access to HIV/ AIDS treatment [1], the world continues to severely under-invest in efforts to fight HIV/ AIDS, missing a tre- mendous opportunity to change the course of the epi- demic by bringing ... avert up to two-thirds of the 45 million HIV infections projected to occur between 2002 and 2010 [7], and a study in early 2005 affirmed that expanded access to t...

Ngày tải lên: 10/08/2014, 05:20

... 7:42 http://www.aidsrestherapy.com/content/7/1/42 Page 5 of 8 RESEA R C H Open Access Varied sensitivity to therapy of HIV-1 strains in CD4 + lymphocyte sub-populations upon ART initiation Edwin J Heeregrave 1 , ... lifespan of infected cells and viral latency prevent eradication. In this study we analyzed the sensitivity to ART of HIV-1 strains in...

Ngày tải lên: 10/08/2014, 05:21

... salivary HIV RNA may be a useful analyte for detec tion of HIV infection for monitoring responses to ARV therapy. Conclusions Our observations revealed transmission of HIV infection from the smear of ... JI: HIV- 1 evolution in vivo tracked by DNA heteroduplex mobility assays. J Virology 1994, 68: 6672-6683. 7. Shirly LR, Ross SA: Risk of transmission of human imm...

Ngày tải lên: 10/08/2014, 05:22

... Clinical Immunology Laboratory that performed the flow cytometry assays and CSF CCL2 ELISA assays, and analysed and interpreted flow cytometry data. RWP designed and oversaw the study, examined ... lentivirus infection, immune activation, and brain injury in model systems. To initiate assessment of minocycline as an adjuvant therapy in human CNS HIV infection, we conducted an o...

Ngày tải lên: 10/08/2014, 05:22

... Access Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the efficacy of a Listeria vaccine in the induction of immune responses against ... al.: Prior exposure to an attenuated Listeria vaccine does not reduce immunogenicity: pre-clinical assessment of the...

Ngày tải lên: 11/08/2014, 08:21

... Vaccines Open Access Original research Longitudinal changes in HIV-specific IFN-γ secretion in subjects who received Remune™ vaccination prior to treatment interruption Kenneth H Huang 1 , Marie-Pierre ... breadth of HIV-specific responses detected in IFN-γ ELISPOT and intracellular cytokine secretion assays increased from on treatment time points pre-TI#...

Ngày tải lên: 11/08/2014, 10:23

... HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+ L74I enzyme and a replication competent virus HimaBindu Chunduri 1 , David Rimland 2 , ... five independent processivity assays were performed f or each RT and statistical values that include mean, median, standard deviation and...

Ngày tải lên: 11/08/2014, 21:21

... APOBEC3G is incorporated into HIV-1 virions and deaminates dC to dU in minus single- strand nascent cDNA within newly infected cells; result- ing in lethal G -to- A hypermutations in the single stranded ... deoxythymidine triphosphate (dTTP), associated with low levels of thymidine phosphorylase, the enzyme that converts thymine into thymidine [27]. Both dTTP and thymidine phosp...

Ngày tải lên: 12/08/2014, 23:23

... T-cell apoptosis are observed that does not totally block the production of proinflammatory cytokines [111,158]. The combination of IL-4/IL-13 c ytokines and proinflamma- tory cytokines in the mi ... anti-inflammatory and tissue repair properties. Finally IL-10 has been described as the proto- typic cytokine involved in the deactivation of macrophages (dM). Since the capacity...

Ngày tải lên: 12/08/2014, 23:23

... evolution of HIV-1 reverse transcriptase in route to acquisition of Q151M multi-drug resistance is complex and involves mutations in multiple domains Jean L Mbisa 1* , Ravi K Gupta 2 , Desire Kabamba 3 , ... reduced susceptibility to all nucleoside reverse transcriptase inhibitors (NRTIs) excluding tenofovir (TDF). This pathway emerges after long...

Ngày tải lên: 13/08/2014, 01:20

... control T cells are equally susceptible to HIV-1 in the absence of DC, demonstrating that the DC-mediated transmission itself is impaired, instead of the ability of HIV-1 to infect these cells. The ... smaller number of T cells that is tightly attached to DC will result in a decrease of the window of opportunity for HIV-1 transmission. Fu...

Ngày tải lên: 13/08/2014, 09:20

... not for citation purposes) Reduced susceptibility of EU CD4 T cells to infection by pseudotyped HIV-1Figure 1 Reduced susceptibility of EU CD4 T cells to infection by pseudotyped HIV-1. CD4 T cells ... suggesting that the mechanisms of resist- ance in these subjects do not depend on exposure to the virus but rather might be linked to constitutive factors....

Ngày tải lên: 13/08/2014, 09:20

... and 40-GCTAGA TACCCAGAAGAGTTGGAAG (nt 294–309) for SIV MAC251 , AC37-CACTCCCAACGAAGAC AAG (nt 9100–9120) and AC38-CAGCAAGCC GAGTCCTGCGT for HIV-1 (nt 699– 708), AC375-TGGGATGAGTATTGGAACCCTGAA ... 292–320) and AC378-AAAAGTCCTCAACAAAGAGACTC (nt 217– 239) for FIV, AC292-GCTGTTGCAT CCGACTCGTG (nt 60–79) and AC293-CACC GCAGATATCCTGTTTG (nt 7975–7994) for MLV ; mitochondrial DNA, 98-GAAT- GTCTG CAC...

Ngày tải lên: 13/08/2014, 09:20

... cells, blocks to N-tropic MLV and EIAV in human cells were thought to be due to the restriction factor 1 (Ref1) [25], and those to HIV-1 and SIV in monkey cells to the lentivi- rus susceptibility factor ... repeated deoxycytidines (GG on the opposite strand) [72], hA3F prefers deoxycytidines followed by deoxythymidines (GA on the opposite strand) [4,7]. The key step for the anti-vir...

Ngày tải lên: 13/08/2014, 09:21

... Health Open Access Case study Universal access: the benefits and challenges in bringing integrated HIV care to isolated and conflict affected populations in the Republic of Congo Daniel P O'Brien* 1 , ... engagement The introduction of HIV care, initially by an international NGO, acted as a catalyst for the MoH and other actors to enga...

Ngày tải lên: 13/08/2014, 13:21