Báo cáo y học: " HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors" docx
Báo cáo y học: " HIV-1 reverse transcriptase mutations that confer decreased in vitro susceptibility to anti-RT DNA aptamer RT1t49 confer cross resistance to other anti-RT aptamers but not to standard RT inhibitors" docx
... N265 may not play akey role in binding to RT8 . It is also interesting that N255D mutant displays a 10-fold hypersensitivity to RT8 .We surmise that N255 residue may be involved in binding to RT8 ... the aptamers (RT2 6, RT4 and RT6 ),the pattern of resistance was very similar to that seen with RT1 t49 in that the reduction in susceptibility was small in the case of RTs containing single mutations, ... sensitivity of HIV-1 RT to other DNA and RNA aptamers directed to HIV-1 RT [21,23]. RT1 t49 and 5 other DNA aptamers rep-resenting each of the six classes of DNA aptamers described by Schneider...
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Báo cáo y học: " Phase IIb randomized trial of adjunct immunotherapy in patients with first-diagnosed tuberculosis, relapsed and multi-drug-resistant (MDR) TB" doc
... used in this arm are abbreviated as follows: Isoniazid (H), Rifampicin (R), Pyrazinamide (Z), Ethambutol (E), Streptomycin (S), Ofloxacin (O), Amikacin (A), Capreomycin (C), Para-aminosalicylic ... were earlier indications that V5exhibits the anti-inflammatory activity [4-8]. Theseobservations are supported by this study. Contrary to the outcome in placebo group the markers of inflamma-tion ... to Mycobacterium tuberculosis excretory secretory antigensby peroxidase enzyme immunoassay. Indian J Tuberc 2010, 57:67-74.17. Vilaplana C, Montané E, Pinto S, Barriocanal AM, Domenech G, Torres...
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Tài liệu Báo cáo Y học: BIGH3 (TGFBI) Arg124 mutations influence the amyloid conversion of related peptides in vitro Implications in the BIGH3-linked corneal dystrophies pptx
... local factors may also explain the corneal involve-ment in other forms of amyloidosis [26]. In summary, autosomal dominant corneal diseases linked to mutations in the BIGH3 gene are a prominent ... transformation.Blocking the Cys residues decreased amyloid formation byapproximately 50%, demonstrating that Cys–Cys bondformation does facilitate amyloid precipitation, but is not the only factor responsible ... results reported in our study are in keeping with these recent clinical reports, as theydemonstrate the capacity of forming amyloid fibrils in vitro for all the peptides assessed, including the native...
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Báo cáo Y học: Introducing Wilson disease mutations into the zinc-transporting P-type ATPase ofEscherichia coli The mutation P634L in theÔhingeÕ motif (GDGXNDXP) perturbs the formation of the E2P state pdf
... the metal binding andphosphorylation sites. It should be noted that binding of themetal ion initiates the catalytic cycle [6]. This binding event in the TM part should trigger changes in the P ... involved in binding of Mg2+[34–37]. Moreover, the E1 to E2transitionmay be linked to changes in Mg2+ligation so that in the E1state Mg2+is ligated by residues in the hinge motif in ... C. Toyoshima Tokyo University, Japan)suggests that P709 can interact with the A domain (see also[37]). In any event, our results s upport the idea that thehinge m otif GDGXNDXP is not only...
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Báo cáo y học: "LV reverse remodeling imparted by aortic valve replacement for severe aortic stenosis; is it durable? A cardiovascular MRI study sponsored by the American Heart Association" pot
... myocyte hypertrophy is not the only pathology that must be accounted for and con-sequently regress post-AVR. Were both sarcomerehypertrophy and collagen expression to be finely gov-erned by ... increasing due to aortic and peripheralchanges in compliance and arterial inelasticity due to aging. The surgically induced relief of a fterload may becounterbalanced by the resultant increase another ... completed in the first 6 months with clinicallyinsignifcant changes detected subsequently. In that thefirst oportunity to detect the changes was by protocoldefinedat6months,itisconceivablethatoneormoreof...
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Báo cáo y học: "Prohormones for prediction of adverse medical outcome in community-acquired pneumonia and lower respiratory tract infections"
... defined previously [34]. Thereby, LRTI wasdefined by the presence of at least one respiratory symp-tom (cough, sputum production, dyspnea, tachypnea,pleuritic pain) plus at least one finding ... Obrosky DS, Peyrani P, Johnson B, Hooy M, Grayson ML: SMART-COP: a tool for predicting the need for intensive respiratory or vasopressor support in community-acquired pneumonia. Clin Infect ... 14distress syndrome within 30 days following inclusion.The secondary endpoint was overall survival within 30days following study inclusion. Outcomes were assessedduring hospital stay at days 3,...
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Báo cáo y học: "The evolving story of medical emergency teams in quality improvement"
... Academic centersare increasingly recognizing engagement in quality improvement asa distinct career pathway. Involving such physicians in medicalemergency teams will likely facilitate the dual ... The increased effort required for thestudy consisted of only a 5-minute debriefing to fill out thestandardized MET form on each patient and a weekly 1-hourCommentaryThe evolving story of ... This methodology captures importantopportunities for improvements in local care at a rate far higherthan routine incident-reporting systems, but without requiringsubstantial investments of...
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Báo cáo y học: "Trace Elements, Heavy Metals and Vitamin Levels in Patients with Coronary Artery Diseas"
... sig-nificantly lower in patients with CAD compared to the control group. Other investigators have also re-ported decreased retinol levels in patients with CAD (31,32). In other studies, Levels of retinol ... strongest supporting evidence that Fe is a risk factor for CAD stems from a cohort study of eastern Finnish men, in which high levels of serum ferritin and dietary Fe intake were positively associated ... coronary disease (1,22). However, a large prospective study found no benefit of tocopherol supplemantation in preventing CAD. Levels of to- copherol were reported to be decreased in coronary artery...
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Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"
... exact drainage system of the frontal sinus depends on its embryologic development [2,13]. The drainage usually occurs directly into the frontal recess [14] or into the frontal recess by way of ... ex-tending above a line tangential to the supraorbital margin (horizontal line). Frontal sinus aplasia is also defined by an oval-shaped sinus with the lateral margin medial to a vertical line ... similar to the frequency in our study (1.22%). Spaeth et al. [27] noticed that agenesis of the frontal sinus was more frequent in women. Aydinlioğlu et al. [1] reported that the incidence...
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Báo cáo y học: "Optimization of 5-fluorouracil solid-lipid nanoparticles: a preliminary study to treat colon cancer"
... formulation parameters; including type of Dynasan, soyalicithin:Dynasan ratio, drug:total lipid ratio, and polyvinyl al-cohol (PVA) concentration were studied with respect to particle size and drug ... 30. Yassin AE, Alsarra IA, Alanazi FK, et al. New targeted-colon delivery system: in vitro and in vivo evaluation using x-ray imaging. J Drug Target. 2010; 18: 59-66. 31. Alanazi FK, Yassin ... w a s obtained by dividing that difference by the total weight of SLNs according to the following formulae: Scanning el e c t r o n microscopic (SEM) analysis The morphology characteristics...
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