... systemoften stimulate allergic reactions in the brain, sometimeswomi_E 5/ 6/03 2 :12 PM Page 18 5 Epidemics and pandemics WORLD OF MICROBIOLOGY AND IMMUNOLOGY 19 3••specificity. The active site of ... devastating epidemic swept through Spain,France, the Netherlands, and the British Isles in 14 26 14 27.Major outbreaks occurred in 15 10, 15 57 , and 15 80. In theeighteenth century there were three to five ... present.womi_E 5/ 6/03 2 :12 PM Page 19 1Electron microscope, transmission and scanning WORLD OF MICROBIOLOGY AND IMMUNOLOGY 17 9••ten or twenty thousand more patients. There was no halting thedemand,...