Báo cáo y học: "Mutation discovery in mice by whole exome sequencing" potx

... (CIA) in mice, indicating that inter- action between CD97 and its ligands may be involved in cell migration in arthritis [21]. CD97 is expressed by inflammatory cells, mainly leukocytes, in RA synovium ... (reviewed in [85]). Other polymorphic genes thought to be involved in RA include protein tyrosine phosphatase N22 (PTPN22), CTLA4, peptidyl arginine deiminase type IV and mac...

Ngày tải lên: 09/08/2014, 10:22

... chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) to examine the variability in transcription factor binding among individuals in yeast (Saccharomyces cerevisiae) and human. In ... encourages the integrity of scientific investi gation. Taylor demonstrated by an analysis of a mitochondrial genome resequencing experiment that commercial cloud computing platform...

Ngày tải lên: 09/08/2014, 20:22

... Biochemistry of the Charité, Berlin, Germany using the ABI PRISM Big Dye Terminator system (Applied Biosystems, Germany). Sequences were analyzed using the Chromas software (Technely- sium Pty Ltd, ... healthy individuals. Interestingly, this SNP had not yet been registered in any SNP databases despite of its high frequency of 20% in samples of patients with AML and 13,7% in healt...

Ngày tải lên: 31/10/2012, 16:49

... with draining lymph node size. In summary, TNF induces OCPs to produce VEGF-C through NF-κB, leading to significantly increased lymphangiogenesis in joints of arthritic mice. The lymphatic system may ... of various cell types that produce a vast array of inflammatory mediators, including cytokines and chemokines that destroy the extracellular matrix in the joint by direct and indirec...

Ngày tải lên: 09/08/2014, 10:21

... planning, teaching and training responsibilities offers possibilities for planning, teaching and training disaster medicine by giving immediate feed- back based on real incidents. Background Introduction To ... be included in the risk assessment regarding possible major incidents in this region. The purpose of this study was to find whether this institution has achieved its primary task...

Ngày tải lên: 25/10/2012, 09:56

... portacaval shunting, thereby decreasing first pass metabolism; decrease in quantities and affinity of plasma proteins, thereby increasing free-drug levels; increase in volume of distribution in patients ... Angiotensin Converting Enzyme CYP = Cytochrome P450 + Not all agents are appropriate for monotherapy. Inclusion in this table does not necessarily imply efficacy. * Currently FDA...

Ngày tải lên: 25/10/2012, 10:51

... craniectomy in decreasing ICP and improving pr o g n o sis in patients wi th refractory in- tracranial hypertension after TBI. 2-8 Presently, th e European Brain Injury Consortium and Brain Trauma ... Nerv Syst 2005;21:1014-1015. 48. Taylor A, Butt W, Rosenfeld J, et al. A randomized trial of very early decompressive craniectomy in children with traumatic brain injury and susta...

Ngày tải lên: 25/10/2012, 11:40

... 237 Microbiologic procedures in joint infections A differentiation of arthritis is practicable by examination of typical laboratory medicine and mi- crobiology characteristics in joint fluid. In addition to ... a large number of different binding molecules. Espe- cially fibrinogen, extracellular matrix proteins and glycosaminoglycans, including fibronectin and laminin, are compo...

Ngày tải lên: 26/10/2012, 09:57

... common polymorphisms in DNA repair genes are continuously being identified, and these polymorphisms may play a pivotal role in sporadic carcinogenesis. A growing body of literature, including observations ... important for maintaining DNA integrity and preventing carcinogenesis. Recent lung cancer studies have focused on identifying the effects of single nucleotide polymorphisms (SNP...

Ngày tải lên: 31/10/2012, 14:59

... following lengthy incubation periods. However, synthetic prions were not able to transmit disease directly to wild type mice. To obtain infectivity in wild type mice, synthetic prions were Int. ... produc- ing infectious amyloid fibrils, infectivity remained the most controversial characteristic of the amyloid fibrils generated by this assay. Prusiner and colleagues in- duced am...

Ngày tải lên: 03/11/2012, 11:52