Báo cáo y học: "The promise and limitations of population exomics for human evolution studies" doc

... variation and evolutionary history, but there are signicant challenges to overcome before this becomes a reality. © 2010 BioMed Central Ltd The promise and limitations of population exomics for human ... events (in units of thousands of years, kyr) and population sizes are indicated. (b) The site frequency spectrum for sample sizes of 50 and 2,000 chromoso...

Ngày tải lên: 09/08/2014, 23:20

... likely to be easy to both genotype and sequence. The sensitivity of SNP and indel detection in repetitive or copy-number-variable regions will be lower. Finally, a non-trivial proportion of any ... systems - but no explicit comparison of the two versions has yet been published. Minireview The promise and reality of personal genomics Bryndis Yngvadottir, Daniel G MacArthur,...

Ngày tải lên: 09/08/2014, 20:20

... Virology 259, 176–189]. In the p resent study, we have studied in vitro two features of the DNA polymerase activity of BLV RT, t he processivity of DNA synthesis and the fidelity of DNA synthesis. ... processivity and fidelity of DNA synthesis exhibited by the reverse transcriptase of bovine leukemia virus Orna Avidan, Michal Entin Meer, Iris Oz and Amnon Hizi Department of...

Ngày tải lên: 31/03/2014, 21:21

... high level of security, of scrutiny and of standardization, and under good labora- tory practices and quality control. Many of these compa- nies subscribe to and offer postmarketing quality assurance ... chain of production, use and application of autoantibody test kits. 198 Patient The ongoing demands of quality control and quality assur- ance are highly dependent o...

Ngày tải lên: 09/08/2014, 01:23

... healthy synovial membrane consists of a thin layer of fibroblast-like synoviocytes (FLSs) and macrophages. These cells produce glycosaminoglycans such as hyaluronic acid and lubricating glycoproteins ... staining of a hyperplastic RA synovial lin- ing cell layer. This staining was typical of most areas of RA synovium where the lining was hyperplastic. (h) An area of an RA syn...

Ngày tải lên: 09/08/2014, 10:20

... article and many more, are likely be important in dynamically shaping the spatial environment and organization of the genome. Specialized transcription factory Transcription factory Regulatory protein Nuclear ... Fullwood MJ, Liu MH, Pan YF, Liu J, Xu H, Mohamed YB, Orlov YL, Velkov S, Ho A, Mei PH, Chew EG, Huang PY, Welboren WJ, Han Y, Ooi HS, Ariyaratne PN, Vega VB, Luo Y, Tan P...

Ngày tải lên: 09/08/2014, 20:21

... ortholog of HRPC2 (91% amino acid identity). Shinmyo et al. [64] have studied the promoter activity and wound-induction of HRPC and -E types, and of AtPCa and AtPEa. Most remarkably, C2, and only C2, responded ... a nonglycosylated triplet at position Asn70 [48]. The majority of the peroxidases carry one or two putative glycans. Seven appear to be nonglycosylated. Therefore,...

Ngày tải lên: 21/02/2014, 01:21

... b). Figure 1 Localization of metallothionein (MT) isoforms I + II in healthy kidneys and in lupus nephritisLocalization of metallothionein (MT) isoforms I + II in healthy kidneys and in lupus nephritis. ... the time of biopsy for all SLE patients: sex, age at time of biopsy, age at time of SLE diagnosis, date of first renal biopsy, date of onset of nephritis symptoms (de...

Ngày tải lên: 09/08/2014, 10:23

... Golakoti T, Sarma KV, Dey D, Raychaudhuri SP. A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin ® for treatment of osteoarthritis of the knee. Arthritis ... accounting for 25% of visits to primary care physicians. It is estimated that 80% of the population will have radiographic evidence of OA by age 65 years, although only...

Ngày tải lên: 25/10/2012, 11:40

... novo synthesis, catalysed by phosphatidylinositol synthase (EC 2.7.8.11), also known as CDP-diacylglycerol (DAG)/myo- inositol 3-phosphatidyltransferase, and an exchange reac- tion whereby the ... phosphatidylinositol; PtdOH, phosphatidic acid; CDP-DAG, CDP-diacylglycerol; CMP, cytidine monophosphate; CTP, cytidine triphosphate. Enzymes: phosphatidylinositol synthase or CDP-diacylglycerol/...

Ngày tải lên: 22/02/2014, 04:20