Báo cáo y học: " Differential patterns of intronic and exonic DNA regions with respect to RNA polymerase II occupancy, nucleosome density and H3K36me3 marking in fission yeast" pps

... Wilhelm et al.: Differential patterns of intronic and exonic DNA regions with respect to RNA polymerase II occupancy, nucleosome density and H3K36me3 marking in fission yeast. Genome Biology 2011 12:R82. Submit ... Biology 2011, 12:R82 http://genomebiology.com/2011/12/8/R82 Page 3 of 12 RESEARC H Open Access Differential patterns of introni...

Ngày tải lên: 09/08/2014, 23:20

... investigating the effect of pro-inflammatory cytokines in intestinal alkaline phosphatase (IAP) gene expression comes to further support the possible role of histone acetylation in intestinal inflammation. ... levels of K5 and K16 acetylation. Finally, in biopsies of inflamed bowel and in Peyer’ s patches of Crohn’s disease patients, K8 and K12 were both s ignificant...

Ngày tải lên: 11/08/2014, 03:20

... (NF-B), which is involved in pro-inflammatory cytokine gene transcription, is increased in the intestinal mucosa o f CD patients [31]. Modulation of histone acetylation is involved in tran- scriptional ... between inflamed and non-inflamed tissue particularly with respect to K8 and K12 acetylation. This specificity towards lysine acetyla- tion could be explained by the sele...

Ngày tải lên: 11/08/2014, 06:22

... these cytokines are refractory to stimulation. An unusual feature of the IL-6 cytokine family is that the soluble forms of the ligand binding receptor subunits generated by one cell type in complex ... leukemia inhibitory factor (LIF), oncostatin M, cardiotrophin-1 (CT-1), and novel neurotrophin-1 (NNT- 1)/cardiotrophin-like cytokine (CLC) [3–7]. All IL-6 type cytokines use a membra...

Ngày tải lên: 22/02/2014, 07:20

... synthetase, inhibition of CoA-IT results in an increase in free AA and a corresponding build-up of AA in triacylglycerols that can be prevented by co-incubation of cells with CoA-synthetase inhibitors ... is incorporated into cellular glycerophospholipids by a distinct pathway. Free AA is initially converted to AA-CoA by AA-CoA synthe- tase (a) [46]. Inhibitors of AA-CoA s...

Ngày tải lên: 22/02/2014, 07:20

... access [14]. In contrast to all Fe-hydrogenases including HydA of S. obliquus,the enzyme of C. reinhardtii has an interesting additional protein domain. A small insertion of 45 amino acids between ... anaerobic proteins is the result of a n increased mRNA level. Maize (Zea mays L.) responds to anaerobic stress by redirect- ing t he synthetic machinery towards the synthesis of...

Ngày tải lên: 08/03/2014, 22:20

... B), followed by cytospin analysis and staining (·1000). (B) HL-60 cells treated with 1.4% dimethylsulfoxide, followed by cytospin analysis and staining (·1000). (C) HL-60 cells in suspension ... proteins involved in a wide variety of cellular processes ranging from signal transduction to RNA processing [28]. Proteins containing WD repeats are often physically associated with...

Ngày tải lên: 17/03/2014, 23:20

... IL-1. Results Glycosaminoglycan release into media The release of GAG into the media was measured daily as a surrogate for monitoring the effect of IL-1 exposure and of ECM stability following IL-1 withdrawal. ... recovery (third week) occurring only in regions with higher [GAG]. With respect to the spatial heterogeneity in recovery rates, we are not aware of any histo...

Ngày tải lên: 09/08/2014, 01:21

... for- mation in the developing embryo by antagonizing Ang-1- induced autophosphorylation of Tie2 [6]. Transgenic mouse models of Tie2/Ang-1 result in embryonic lethality due to absence of remodeling and ... receptors and the ligands Ang-1 and Ang-2 in RA synovial tissue. To deter- mine which of these angiogenic factors may play a role in RA, we investigated both the d...

Ngày tải lên: 09/08/2014, 03:24

... with thickening of the lining layer (or intima) and infiltration of the sublining layer, mainly by macrophages and lymphocytes [1]. In addition, the fluid- filled joint cavity contains numerous ... cell infiltrates and a thickened intimal layer. In two of these individuals a minority of synovial samples also showed microscopically normal regions with minimal infil- tra...

Ngày tải lên: 09/08/2014, 03:24