... the type of microarray data normalization, and the optimization algorithm for learning the parameters of the dynamical model. For each of these, we selected the best hyperparameters, namely the ... pic- ture of the behavior of the genetic network over time, but they contain this information in a highly noisy form requiring reverse engineering [31]. A n additional cha...
Ngày tải lên: 09/08/2014, 22:23
... mesenchymal benign lesions origi- nating from the mature lipid tissue 1 . They constitute approximately 0.6% of the laryngeal and hypopha- ryngeal benign tumors 4 . Laryngeal and hypopharyn- geal ... indistinct symptoms 5,7 . In this case, the feeling of a mass in the throat without dysphagia was the only symptom of large pyriform sinus lipoma. The preferred method of...
Ngày tải lên: 25/10/2012, 10:51
Báo cáo y học: "Aplasia and Agenesis of the Frontal Sinus in Turkish Individuals: A Retrospective Study Using Dental Volumetric Tomograph"
... age of 8 years, the top of the frontal sinuses is at the level of the orbital roof, and by the age of 10 years, the sinuses extend into the vertical portion of the frontal bone. The final ... By the age of 4 years, the average cranial extent of the frontal sinus reaches half the height of the orbit and extends just above the top of the mos...
Ngày tải lên: 25/10/2012, 11:04
Tài liệu Báo cáo Y học: NMR-based determination of the binding epitope and conformational analysis of MUC-1 glycopeptides and peptides bound to the breast cancer-selective monoclonal antibody SM3 pptx
... affinity of glycopeptides to the antibody [18]. Conventional pepscan analysis however, does not allow easy analysis of the contribution of the carbohydrate portion. To assess the involvement of carbohydrates ... residue and/or by the binding contribution from theGalNAcresidue. Docking the glycopeptide to the antibody the sugar ring has little contact to the protein su...
Ngày tải lên: 21/02/2014, 15:20
Tài liệu Báo cáo Y học: Steady-state kinetics of the glutaminase reaction of CTP synthase from Lactococcus lactis The role of the allosteric activator GTP in coupling between glutamine hydrolysis and CTP synthesis potx
... the phosphorylation of UTP and hydrolysis of glutamine for optimal efficiency in CTP synthesis rather than just acting to increase the rate of glutamine hydrolysis itself. Keywords: CTP synthase; isothermal ... that if the role of GTP was solely to increase the rate of glutamine hydrolysis, there would have been no effect of adding GTP when the rate of CTP synthesis was...
Ngày tải lên: 21/02/2014, 15:20
Tài liệu Báo cáo Y học: Presence and regulation of the endocannabinoid system in human dendritic cells potx
... 2-arachidonoylglycerol (2-AG), the cannabinoid CB 1 and CB 2 receptors, and one of the enzymes mostly responsible for endocannabinoid hydrolysis, the fatty acid amide hydrolase (FAAH). By using a very ... on the basis of the sequence of the FAAH gene (NCBI accession number AF098010) by including the introns 5476–6026 and 6173–6296, and of the sequence of the glycer...
Ngày tải lên: 22/02/2014, 07:20
Báo cáo Y học: Osmoregulated periplasmic glucans of the free-living photosynthetic bacterium Rhodobacter sphaeroides doc
... form); (b) they are linked by b-1,2 linkages and one a-1,6 linkage; and (c) they are highly substituted by succinyl and acetyl residues. They also exhibit some degree of structural rigidity as demonstrated ... revealed the presence of a major peak with retention times of 36 min (data not shown). Others compounds probably correspond to the other cyclic glucans observed by MALDI-MS. F...
Ngày tải lên: 17/03/2014, 17:20
Báo cáo Y học: A functional role of the membrane-proximal extracellular domains of the signal transducer gp130 in heterodimerization with the leukemia inhibitory factor receptor pot
... C-terminally to the CBM that play specific roles in activation of the receptor by these two cytokines. The ligand independent activation of the D5-GCSFR chimera occurs in both the absence and the presence ... copre- cipitation of gp130 with LIFR independently of the lysis buffer used for the disintegration of the cells (data not shown). Because of the high expre...
Ngày tải lên: 18/03/2014, 01:20
Báo cáo Y học: Cloning and characterization of the mammalian-specific nicolin 1 gene (NICN1) encoding a nuclear 24 kDa protein doc
... detailed analysis of the expression of the Nicn1 gene at days 8.5, 9.5, and 10.5 of murine development was performed by in situ hybridization of digoxigenin-labeled riboprobes to whole- mount mouse embryos. ... 100. The height of the other bars indicates the relative amount of NICN1 mRNA in the other tissues. (A) In the human Northern blot, NICN1 signal intensi- ties...
Ngày tải lên: 23/03/2014, 21:20
Báo cáo Y học: Chimeric receptor analyses of the interactions of the ectodomains of ErbB-1 with epidermal growth factor and of those of ErbB-4 with neuregulin potx
... of the receptors was confirmed by immunoblotting of the cell lysates (Fig. 1B). As often observed for membrane proteins, the bands were rather broad in the blots, due to the heterogeneity of the ... of the receptor [19,22]. The b sheet of EGF may bind to domain I of ErbB-1, and the other surface of the ligand binds to domain III of the receptor. Recently,...
Ngày tải lên: 24/03/2014, 03:21