Báo cáo y học: "Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford Progeria syndrome cells" doc

... acceptance. Copyedited and fully formatted PDF and full text (HTML) versions will be made available soon. Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome ... interior (Figure 2.II G-L) and chromosome X remains at the nuclear periphery (Figure 2.II M-R). Farnesyltransferase inhibitor treatment restores wild...

Ngày tải lên: 09/08/2014, 23:20

... lamin A. Keywords: chromosome territories, lamin A, Hutchinson-Gilford Progeria Syndrome, nuclear motors, premature ageing, nuclear myosin 1β, farnesyltransferase inhibitor, geranylgeranyltransferase ... interior in proliferating laminopathy cells, including an HGPS cell-line [41]. The X chromosome remains at the nuclear periphery in all cell cycle states and is located...

Ngày tải lên: 09/08/2014, 23:20

... Stress and Psychiatry. In Comprehensive Textbook of Psychi- atry, 6th Edition Edited by: Kaplan HI and Sadock BJ. Baltimore, Wil- liams and Wilkins; 1995:1545-1559. 19. Coryell W, Endicott J, Andreasen ... first day, and determination of cortisol serum levels simultaneously and the next day at 16.00 and 23.00. Cortisol levels expressed in µg/dl were measured with Luminance Im...

Ngày tải lên: 08/08/2014, 20:23

... salivary levels of vasoactive intestinal peptide (VIP) and neuropeptide Y (NPY), which are mainly found in parasympathetic and sympathetic nerves, respectively. This finding indicates increased ... Sorsa T, Konttinen YT: Distri- bution of vasoactive intestinal peptide (VIP) and its binding sites in labial salivary glands in Sjogren's syndrome and in normal controls. C...

Ngày tải lên: 09/08/2014, 01:22

... major phenotypic shift occurs in OA toward a de-differentiated chondrocyte [40]. Interestingly, in the present study we observed increased amounts of types I and III collagens by immunohistology in both ... meniscectomy). Changes in collagen subtypes in pathological cartilage may not only influence the biomechanical integrity of the tissue but may sequester and modulate the acti...

Ngày tải lên: 09/08/2014, 06:23

... was performed in culture medium containing 1% heat-inactivated FCS. The monocyte purity and lym- phocyte purity were assessed by flow cytometry, and fractions were typically >80% and 90% pure, ... pro- tein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines. J Biol Chem 1990, 265:21128-21133. 42. Wood LD, Richmond A: Constitutive and...

Ngày tải lên: 09/08/2014, 08:23

... of inducing other proinflammatory cytokines and activating matrix metalloprotei- nases in autocrine and paracrine fashions [2]. Inhibitors of IL- 1 and TNF-α cause a reduction in synovial inflammation, ... HY, Huang HC, Ko CH, Yang LL, Chen YC: In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostag...

Ngày tải lên: 09/08/2014, 10:22

... 3,3'-diaminobenzidine (Vector Laborato- ries) containing hydrogen peroxide. The slides were counter- stained with eosin. The specificity of staining was evaluated by substituting the primary antibody ... lipopolysaccharide-induced TNF-α expression by enhancing mRNA decay [19]. Alternatively, 15-LOX products could prevent IL-1β-induced MMP-1 and MMP-13 expression by interfering with key...

Ngày tải lên: 09/08/2014, 14:20

... functions in phagocytes including induction of cytokines and chemokines, possibly by collaborating with TLRs, involvement in endocytosis and phagocytosis and pro- duction of the respiratory burst ... is induced in human joint tissues, including chondrocytes and synoviocytes, by inflammatory stimuli such as interleukin 1β (IL1β), IL17, and tumor necrosis factor (TNF) [12-20] a...

Ngày tải lên: 09/08/2014, 14:20

... that cytokines can be involved in cartilage tissue or proteoglycan degradation [6]. It has recently been shown in a serum-containing porcine in vitro model that these cytokines are able to inhibit ... inhibition by pro-inflammatory cytokines in a serum-con- taining porcine model. However, in our study most of the MMP-3 in the culture supernatant was in the pro-form, and it rem...

Ngày tải lên: 09/08/2014, 14:22