Báo cáo y học: "Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford Progeria syndrome cells" doc
Báo cáo y học: "Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford Progeria syndrome cells" pot
... acceptance. Copyedited and fully formatted PDF and full text (HTML) versions will be made available soon.Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome ... interior (Figure 2.II G-L) and chromosome X remains at the nuclear periphery (Figure 2.II M-R). Farnesyltransferase inhibitor treatment restores wild-type interphase chromosome positions in ... [20,45-46], implying that lamin A is important in chromatin organisation and chromosome territory location in interphase nuclei, both of which are perturbed in laminopathy cells. Furthermore,...
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Báo cáo y học: "Farnesyltransferase inhibitor treatment restores chromosome territory positions and active chromosome dynamics in Hutchinson-Gilford Progeria syndrome cells" doc
... lamin A. Keywords: chromosome territories, lamin A, Hutchinson-Gilford Progeria Syndrome, nuclear motors, premature ageing, nuclear myosin 1β, farnesyltransferase inhibitor, geranylgeranyltransferase ... interior in proliferating laminopathy cells, including an HGPS cell-line [41]. The X chromosome remains at the nuclear periphery in all cell cycle states and is located at the periphery in ... Background Hutchinson-Gilford Progeria Syndrome (HGPS) is a premature ageing syndrome that affects children leading to premature death, usually from heart infarction or strokes, making this syndrome...
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Báo cáo y học: "Relationship among Dexamethasone Suppression Test, personality disorders and stressful life events in clinical subtypes of major depression: An exploratory study" pot
... Stress and Psychiatry. In Comprehensive Textbook of Psychi-atry, 6th Edition Edited by: Kaplan HI and Sadock BJ. Baltimore, Wil-liams and Wilkins; 1995:1545-1559. 19. Coryell W, Endicott J, Andreasen ... first day, and determination ofcortisol serum levels simultaneously and the next day at16.00 and 23.00. Cortisol levels expressed in µg/dl weremeasured with Luminance Immunoassay (intra-essay reli-ability: ... Acta Psy-chiatr Scand Suppl 1994, 377:50-8.5. Evans DL, Golden RN: The Dexamethasone Suppression Test:A Review. In Handbook of Clinical Psychoneuroendocrinology Edited by:Nemeroff CB and Loosen...
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Báo cáo y học: "Impaired vascular responses to parasympathetic nerve stimulation and muscarinic receptor activation in the submandibular gland in nonobese diabetic mice." ppt
... salivary levels of vasoactiveintestinal peptide (VIP) and neuropeptide Y (NPY), which aremainly found in parasympathetic and sympathetic nerves,respectively. This finding indicates increased ... Sorsa T, Konttinen YT: Distri-bution of vasoactive intestinal peptide (VIP) and its bindingsites in labial salivary glands in Sjogren's syndrome and in normal controls. Clin Exp Rheumatol ... peptide-immunoreactive nerve fibres in submandibular glandsDistribution of vasoactive intestinal peptide-immunoreactive nerve fibres in submandibular glands. Light microscopic view of vasoactive intestinal...
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Báo cáo y học: "Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritis" pptx
... majorphenotypic shift occurs in OA toward a de-differentiatedchondrocyte [40]. Interestingly, in the present study weobserved increased amounts of types I and III collagens byimmunohistology in both ... meniscectomy). Changes in collagensubtypes in pathological cartilage may not only influence thebiomechanical integrity of the tissue but may sequester and modulate the actions of cytokines, with types ... with affinity purifiedpolyclonal antibodies directed against the carboxyl-terminus ofdecorin, biglycan, fibromodulin and lumican (0.3–1 µg/ml)[12] followed by washing in TBS-azide and detection...
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Báo cáo y học: "T-cell contact-dependent regulation of CC and CXC chemokine production in monocytes through differential involvement of NFκB: implications for rheumatoid arthritis" docx
... was performed in culture medium containing1% heat-inactivated FCS. The monocyte purity and lym-phocyte purity were assessed by flow cytometry, and fractionswere typically >80% and 90% pure, ... pro-tein-like factor binding elements in activating the interleukin-8gene by pro-inflammatory cytokines. J Biol Chem 1990,265:21128-21133.42. Wood LD, Richmond A: Constitutive and cytokine-inducedexpression ... regulation of cytokine induction by adenoviral genetransfer of IκBα into human macrophages: lipopolysaccha-ride-induced, but not zymosan-induced, proinflammatorycytokines are inhibited, but...
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Báo cáo y học: "Rutoside decreases human macrophage-derived inflammatory mediators and improves clinical signs in adjuvant-induced arthritis" doc
... of inducing otherproinflammatory cytokines and activating matrix metalloprotei-nases in autocrine and paracrine fashions [2]. Inhibitors of IL-1 and TNF-α cause a reduction in synovial inflammation, ... HY, Huang HC, Ko CH, Yang LL, Chen YC: In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. ... vari-ety of inflammatory disorders, including RA and many otherautoimmune diseases [2]. During RA, patients have anincreased number of monocytes, particularly inflammatorymonocytes, circulating in...
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Báo cáo y học: "Human articular chondrocytes express 15-lipoxygenase-1 and -2: potential role in osteoarthritis" pdf
... 3,3'-diaminobenzidine (Vector Laborato-ries) containing hydrogen peroxide. The slides were counter-stained with eosin. The specificity of staining was evaluated bysubstituting the primary antibody ... lipopolysaccharide-induced TNF-α expression byenhancing mRNA decay [19]. Alternatively, 15-LOX productscould prevent IL-1β-induced MMP-1 and MMP-13 expressionby interfering with key signalling ... pepstatin A).After the α-chymotrypsin activity was inhibited with N-tosyl-L-phenylalanine-chloromethyl ketone (Sigma) for 20 minutes,the samples were centrifuged and the supernatants assayedfor...
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Báo cáo y học: "Candida albicans induces cyclo-oxygenase 2 expression and prostaglandin E2 production in synovial fibroblasts through an extracellular-regulated kinase 1/2 dependent pathway" pps
... functions in phagocytes including induction ofcytokines and chemokines, possibly by collaborating withTLRs, involvement in endocytosis and phagocytosis and pro-duction of the respiratory burst ... isinduced in human joint tissues, including chondrocytes and synoviocytes, by inflammatory stimuli such as interleukin 1β(IL1β), IL17, and tumor necrosis factor (TNF) [12-20] and hasroles in ... be involved in the induction of cytokines and chemokines possibly by col-laborating with TLRs [33].Although it is well documented that C. albicans may inducejoint inflammation and destruction,...
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Báo cáo y học: "Tumor necrosis factor alpha-dependent aggrecan cleavage and release of glycosaminoglycans in the meniscus is mediated by nitrous oxide-independent aggrecanase activity in vitro" pptx
... that cytokines can be involved in cartilage tissueor proteoglycan degradation [6]. It has recently been shown in a serum-containing porcine in vitro model that these cytokinesare able to inhibit ... inhibition by pro-inflammatory cytokines in a serum-con-taining porcine model. However, in our study most of theMMP-3 in the culture supernatant was in the pro-form, and itremains unclear to ... interleukin-1, tumor necrosis factor alpha, and interleukin-6 in cartilage proteoglycan metabolism and destruction. Effect of in situ blocking in murine antigen- and zymosan-induced arthritis. Arthritis Rheum...
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