Báo cáo y học: "Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis" ppt
Báo cáo y học: "Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis" ppt
... to human miRNAs, as well as miRNAs of species other than human (mirBase 16), to UCSC annotated sequences (UCSC Refflat file) and finally to non-coding RNA classes (fRNAdb, database of ncRNA.org): ... 12:R64 http://genomebiology.com/2011/12/7/R64 Page 3 of 13 RESEA R C H Open Access Small RNA sequencing reveals miR-64 2a- 3p as a novel adipocyte-specific micr...
Ngày tải lên: 09/08/2014, 23:20
Báo cáo y học: "Amino acid racemization reveals differential protein turnover in osteoarthritic articular and meniscal cartilages" docx
... 149:951-959. 9. Helfman PM, Bada JL: Aspartic acid racemisation in dentine as a measure of ageing. Nature 1976, 262:279-281. 10. Ohtani S, Matsushima Y, Kobayashi Y, Yamamoto Y: Age estima- tion by measuring ... analysis of variance; Asn: asparagine; Asp: aspartate; Asx: asparagine + aspartate; Gln: glutamine; Glu: glutamate; Glx: gluta- mate + glutamine; HPLC: high-performance liq...
Ngày tải lên: 09/08/2014, 13:22
Báo cáo y học: "Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line" pptx
... Salzman AL, Szabo C: Peroxynitrite- mediated DNA strand breakage activates poly-adenosine diphosphate ribosyl synthetase and causes cellular energy depletion in macrophages stimulated with bacterial ... polymerase in NF- kappaB transcriptional activation. Biol Chem 1999, 380:953-9. 38. Kannan P, Yu Y, Wankhade S, Tainsky MA: PolyADP-ribose polymerase is a coactivator for AP-2-mediated tr...
Ngày tải lên: 11/08/2014, 03:20
Báo cáo y học: " Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line." pptx
... structures. It has also been proposed that PARP-1 is part of a nucleosome complex along with a histone variant macroH 2A (mH 2A) . At baseline condi- tions, mH 2A and an inactive PARP-1 are associated with ... units has an adenine moiety c apable of base stacking and hydrogen bonding, along with two phosphate groups that carry negative charges. These polymers cause profound chan...
Ngày tải lên: 11/08/2014, 06:22
Báo cáo y học: "Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblast" pot
... Mogami 3 and Yoshiya Tanaka 1 1 First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan 2 Department of Pharmacology and ... nonfat milk, and analyzed by western blotting using a polyclonal anti-Rho antibody. Statistical analysis Data are expressed as mean ± standard deviation (SD) of the number of...
Ngày tải lên: 09/08/2014, 06:22
Báo cáo y học: " The RNA interference pathway: a new target for autoimmunity" pot
... RNAi machinery is that RNAi was initially recognized as an antiviral mechanism in plants and certain invertebrates [14]. The evolutionary conservation of RNAi suggests a similar role for RNAi in mammals, which ... complex as Dicer, the enzyme that converts dsRNA precursors into functional siRNAs and miRNAs [5]. The disease specificity of anti-Su antibodies has been addressed in...
Ngày tải lên: 09/08/2014, 08:22
Báo cáo y học: " Ubiquitous RNA-dependent RNA polymerase and gene silencing" pptx
... post-transcriptional silen- cing suggested that some type of RdRP activity might be critical in flies and humans as well. For example, aberrant single-stranded RNAs (ssRNAs) are also subject to silen- cing and ... Drosophila and mammals produce other short RNAs called piRNAs that associate with the PIWI family of Argonaute proteins [16-18]. piRNAs are found in abundance in ge...
Ngày tải lên: 09/08/2014, 20:20
Báo cáo y học: "Small variable segments constitute a major type of diversity of bacterial genomes at the species level" pptx
... Bioinformatics 2008, 9:498. 6. Hayashi T, Makino K, Ohnishi M, Kurokawa K, Ishii K, Yokoyama K, Han CG, Ohtsubo E, Nakayama K, Murata T, Tanaka M, Tobe T, Iida T, Takami H, Honda T, Sasakawa C, Ogasawara ... boundary. If no repeat was found, a second search of repeats of length >10 bp with a Hamming distance of 1 was carried out. A final scan was done in case of repea t detec...
Ngày tải lên: 09/08/2014, 20:21
Báo cáo y học: " Short RNA half-lives in the slow-growing marine cyanobacterium Prochlorococcus" pot
... of expressed ncRNAs and asRNAs ncRNA/asRNA Decay rate [min] rnpB (RNase P sRNA) >20 ffs (SRP RNA) >20 ssrA (tmRNA) >20 ssrS (6S RNA; Yfr7) >20 Yfr4 >20 Yfr5 >20 Yfr2 >20 asRNA_04601 ... >20 asRNA_04601 >20 Yfr16 >20 Yfr8 19.7 Yfr14 11.6 asRNA_17331 8.4 asRNA_17181 7.8 ncRNA_Yfr9 6.9 asRNA_15721 4.9 Yfr11 4.8 asRNA_04001 4.2 Yfr6 4.0 asRNA_38 3.5 asRNA_00641...
Ngày tải lên: 09/08/2014, 20:22
Báo cáo y học: "Improving RNA-Seq expression estimates by correcting for fragment bias" doc
... bias parameters and expression values is evidenced by comparison of the raw counts of bases at the starts/ends of fragments (panel a) and the adjusted counts normalized by the abundances of transcripts ... in assigning ambiguously mapped fragments to transcripts and our method takes advantage of this. On the other hand, since read counts have been promoted as an acceptable...
Ngày tải lên: 09/08/2014, 22:24