Báo cáo y học: "Vive la différence: biogenesis and evolution of microRNAs in plants and animals" ppt

... loaded in AGO2 require their 2′-O- methylation to remain stable in the presence of highly complementary targets [102]. Reciprocally, instability of Drosophila miRNAs loaded in AGO1 was induced by ... dsRNA, are methylated by HEN1 as single-stranded species [39-42]. In addition to this core machinery, several accessory factors in uence the biogenesis efficiency, fidelity and...

Ngày tải lên: 09/08/2014, 22:24

... arachnoid cyst; syringomyelia. Introduction The commonest type of arachnoid cyst that causes compression of the spinal cord and develop- ment of syringomyelia is the Chiari malformation type I ... Burkhardt K, Delavellle J, et al. Symptomatic syringomyelia occurring as a late complication of posterior fossa medulloblastoma removal in infancy in a boy also suf- fering from...

Ngày tải lên: 25/10/2012, 11:00

... anaphylaxis showed that delayed or no administration of epinephrine was a factor in many of the deaths [2]. Similar trends were seen in US mortality data recorded by the American Academy of Allergy, ... allergies in terms of restriction of social activities, increased fear and anxiety, lack of understanding by others, and feelings of isolation[5]. To improve support o...

Ngày tải lên: 08/08/2014, 21:20

... Kaladjian A, Azorin JM, Giudicelli S: Clozapine in the treatment of psychotic refractory depression. Br J Psychiatry 1993, 163:822-4. 9. Hrdlicka M: Combination of clozapine and maprotiline in refractory ... than standard, sec- ond and third line treatment for psychotic depression, in improving mood and psychotic symptoms', there remains much uncertainty and we would su...

Ngày tải lên: 08/08/2014, 21:20

... important in predicting PTSD in men and women, it may result in dif- ferences in the resulting psychopathology, which in turn Annals of General Psychiatry 2008, 7:24 http://www.annals-general-psychiatry.com/content/7/1/24 Page ... caring for babies to run or fight in the face of danger. Instead, evolutionary adaptive behaviour has been tending to offspring, calming children...

Ngày tải lên: 08/08/2014, 23:21

... activity of inflammatory cytokines in patients with RA inhibits bone resorption and destruction. IL-23, which was recently identified as a heterodimeric, proin- flammatory cytokine and new member of ... onset of clinical arthritis. Staining of synovial tissues with hematoxylin and eosin showed that treatment with a low dose (3.0 μg) of anti-IL-23 antibody markedly reduced in...

Ngày tải lên: 09/08/2014, 10:21

... in fibroblast-like synoviocytes, as seen by ELISA analysis on culture supernatant. The authors concluded that infiltrating T lymphocytes and myeloid cells are the main sources of NGF in the inflamed ... been considered of importance in various types of inflammatory conditions. In particular, NGF has been detected at high levels in regions with inflammation. Accordingly, ther...

Ngày tải lên: 09/08/2014, 14:22

... for inter- individual variation in recombination [10,23]. This interplay between conservation and variability has been difficult to model. One model explaini ng the rapid evolution of recombination ... Importantly, human Prdm9 protein was predicted to recognize the aforemen- tioned 13-mer motif CCNCCNTNNCCNC in a zinc fin- ger binding array. The f ast evolution of Prdm9 protein...

Ngày tải lên: 09/08/2014, 22:23

... predominantly in the primary tumor genome before initiation of metastasis [9]. In line with this hypothesis is the finding that distinct clonal cell populations in primary pancreatic carcinoma ... validated by PCR and capillary sequencing. Competing interests The authors declare that they have no competing interests Authors’ contributions WK conceived and designed the s...

Ngày tải lên: 09/08/2014, 23:20

... level of suspicion. In addition to signs of retinitis, inflammatory symptoms include vitritis, papillitis, and macular edema, resulting in symptoms of loss of visual acuity and floaters in affected ... tuberculosis (TB) and cryptococcal meningi- tis following initiation of ART [6,7,10,13,16,25-28]. In noninfectious causes of IRIS, autoimmunity to innate antigens play...

Ngày tải lên: 10/08/2014, 05:20