Báo cáo y học: "Community transcriptomics reveals universal patterns of protein sequence conservation in natural microbial communities" pdf

... significantly less abundant in the RNA, being involved in 61% of all decre asing DNA-RNA amino acid frequency changes. In contrast, frequency increases were dominated by amino acids enriched in GC: 50% of increases ... debated. Sequence conservation in highly expressed proteins has been hypothesized to be driven by selection acting to minimize the costs of protein misfol...

Ngày tải lên: 09/08/2014, 22:24

... four Yoruba indi- viduals, respectively; in the Bentley et al. [20] study, one of the Yoruba was whole-genome sequenced; the Perry et al. [13] study examined known copy number variants in 10 Yoruba ... CNV typing The sample-level event calling thresholds used in the segmen- tation analysis of the CNV-typing array data were determined by comparing against reference event calls taken...

Ngày tải lên: 09/08/2014, 20:20

... yields of 20 to 35 micrograms of total RNAs from approximately 100 mg of tissues. Approximately 400 ng of total RNAs were used for cRNA synthesis with Cyanine 3-dCTP and Cyanine5- dCTP (Perkin-Elmer ... and petals in E. calif ornica, we tried to identify putative A-function genes on the basis of regulatory genes expressed in the A domain, hypothesizing that they may function in...

Ngày tải lên: 09/08/2014, 22:23

... characterised by a chronic inflammation of the lachrymal and salivary glands, which leads to exocrine hypofunction and the well recognised clinical features of dry eyes (xerophthal- mia) and dry mouth ... fatigue, myalgia, dry eyes and dry mouth improved, and her residual depressive symptoms improved further. She is currently being maintained on prednisone at a dose of 7.5 mg/day. Her o...

Ngày tải lên: 08/08/2014, 23:21

... significantly cate- gorized by the molecular function of their protein products into categories that included hyaluronic acid binding activity (including Agc1 and Hapln1) and proteinase activity (including Mmp-9 ... probably regulated by inhibitory actions of Egr-1 in competition for Sp1 binding sites. Collectively, these data suggest that, in chondrocytes, alterations in Egr-1 DN...

Ngày tải lên: 09/08/2014, 01:22

... significant finding from our study was that in RA the use in an ELISA of fragments of the intact CII molecule, particularly CB10, as antigen markedly increased the sen- sitivity of detection of antibodies ... and corresponding Coomassie blue protein stain illustrating the separation of the CB peptides of bovine CII with a linear salt gradient (dotted line). (b) Coomassie bl...

Ngày tải lên: 09/08/2014, 01:23

Ngày tải lên: 09/08/2014, 06:23

... amino-terminal two repeats of the death effector domain (DED), it lacks the carboxy-terminal half of the proteolytic domain. Caspase 8L binds to the Fas-asso- ciating protein with death domain ... Luyn 1 , Marc Bijl 2 and Martin C Harmsen 1 1 Department of Pathology and Laboratory Medicine, University Medical Center Groningen, University of Groningen, The Netherlands 2 Department...

Ngày tải lên: 09/08/2014, 10:20

... proteins. Fifty percent of variable ITRs modify protein sequences In agreement with an active role in modifying protein sequences, we found that 50% of the detected ITRs occur in the coding sequence ... occur in polymorphic human pro- teins, such as the keratin-associated proteins, the VCX /Y pro- teins, the nuclear pore interacting proteins, and the prostate- ovary-testis-...

Ngày tải lên: 09/08/2014, 20:21