Báo cáo y học: "Dating the age of admixture via wavelet transform analysis of genome-wide data " pptx

... position. These wave frequencies are then used as a measure of th e width of the ancestral blocks. There are several advantages to the wavelet transform approach. First, wavelet transform of the discrete ... analyze genome-wide admixture structure, and introduce wavelet transform analysis as a method for estimating the time of admixture. We test the wavel...

Ngày tải lên: 09/08/2014, 22:23

... 12:R17 http://genomebiology.com/2011/12/2/R17 Page 6 of 19 of (p)ppGpp in E. coli. Of the many detect ed (p)ppGpp targets that may contribute to the observed stress phe- notypes of the rsh mutant, we performed a phenotypic analysis o ... previously [29], showing the rsh mutant to be (p)ppGpp-deficient. However,duetothesensitivityoftheassay,thepre- sence of trace amounts o...

Ngày tải lên: 09/08/2014, 22:23

... sex, age- group and calendar year), as the publicly accessible ver- sion of the MBS database we used does not allow for the extraction of individual-level data. For each category of procedures, the ... http://www.jfootankleres.com/content/1/1/10 Page 7 of 10 (page number not for citation purposes) Discussion The aim of this study was to explore the epidemiology and co...

Ngày tải lên: 10/08/2014, 21:23

... anticipated. These factors significantly reduced the power of the study. Based on their findings, the authors estimate that more than 100 hospitals would be needed to show the 30% difference they sought. ... goal of identifying and treating patients early in the course of their illness is preferable to waiting until more serious signs and symptoms have developed. Certain...

Ngày tải lên: 25/10/2012, 10:39

... the management of patients have a sound grasp of at least the basics of statistical methods. Unfortunately, in practice this is often not true, with many relying on distant memories of poorly ... regression; and analysis of survival data. Ideally the series will evolve to meet the needs of Critical Care readers, and you are encouraged to suggest additional topics that y...

Ngày tải lên: 25/10/2012, 10:45

... although the HGGG loop was a critical structural element for the catalytic efficiency of the enzyme, the cold adaptation of the enzyme could not be attributed to the presence of the Gly cluster ... explored the possibility of modifying the psychrophilic properties of an enzyme by introducing, via mutagenesis, predictable flexibility changes to key active site resid...

Ngày tải lên: 22/02/2014, 04:20

... the content of secondary structure only after the disruption of the native tertiary structure of RNase A (Figs 2–4). Interestingly, the preservation of the tertiary structure coincides with the ... hydro- chloride (GdnHCl), urea or elevated temperatures, they destroy the tertiary structure of proteins which results in the loss of enzymatic activity. Regarding the...

Ngày tải lên: 22/02/2014, 07:20

... for the final family is given in Fig. S1. Fig. 3A shows the family of 40 structures and Table 1 contains a summary of statistical data indica- ting the quality of the 40 models and the average ... active conformation of the hormone [38,40]. The changes engineered in the sequence of the peptide, either through the nature of the side chain of the new amino...

Ngày tải lên: 17/03/2014, 10:20

... initiated by the lysis of a water molecule in the cytoplasmic phosphorylation site, implying that the proton pathway would begin close to the phosphorylated aspartate (Asp378). The major steps o f the ... catalytic activity proceed essentially by the same mechanism. Indeed, catalytic residues occupy the same position in the 3D structures of the two enzymes. In addition...

Ngày tải lên: 23/03/2014, 21:20

... with 2 lg of the reporter plasmid pCAPCAT, and either 0.5 lg of each of the clones of the overlapping AcMNPV k library or 1.0 lg of each plasmid of the overlapping lef library as described by Passarelli ... by insertion of PCR products into the BglII and PspAI sites of plasmid phsp70HAHisVI+ containing the 5¢ terminal amino acid sequence RYPYDVPDYARA. The sequenc...

Ngày tải lên: 23/03/2014, 21:20