Báo cáo y học: " DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines" ppt

... individual loci driving variation in both methylation and expression. To better understand the role of genetic variation in controlling DNA methylation variation, and its resulting effectsongeneexpressionvariation, ... data taking into account DNA methylation, in only 10% of eQTLs was the gene tic effect of the SNP on expression affected by controlling for met...

Ngày tải lên: 09/08/2014, 22:23

Ngày tải lên: 09/08/2014, 23:20

... (cytokine–cytokine receptor interac- tions). The mean gene expression (blue line) and the intra-group inter-individual variances in RA and NC synovial membrane (red bar) are indicated, resulting in ... significantly affected by higher gene expression variances were identified in RA compared with NC, including cytokine–cytokine receptor interactions, the transforming growt...

Ngày tải lên: 09/08/2014, 10:23

... 30 days before conception and six months post-delivery. In the first analysis, cases were defined as boys with hypospadias recorded in the HDR during the first six months post-delivery. The ... number, and the date of drug dispension. Since January 1 1989 all data from North Jutland County have been stored in a prescription database maintained by the Department of Clinical...

Ngày tải lên: 02/11/2012, 10:09

... cleavages in the interdomain and autolysis loops in the inactivation of chymotrypsin. At first, D-chymo- trypsin and the interdomain and autolysis loop mutants were subjected to digestion with trypsin. ... trypsin mutant with chymotrypsin-like activity (Table 1) was subjected to autolysis and digestion with D-chymo- trypsin and trypsin. Interestingly, despite the presence o...

Ngày tải lên: 22/02/2014, 07:20

... Spanish-sounding words occasionally and spon- taneously coming to his mind. No meaning is associated with these words and the patient easily controls their occurrence with no anxiety. Neurological examination completed ... seen on the brain imaging, involving the left insular and anterior temporal cortex, two brain regions frequently involved in aphasic syndrome but also in FAS,...

Ngày tải lên: 08/08/2014, 21:20

... cannot stay still for long' and 'I am constantly fidgeting or squirming'. These findings indicated that the aforementioned items create a subdimension within the hyperactivity/inatten- tion ... divided into two subdimensions (that is, hyperactivity and inattention). This finding may reflect the inability to assess the multidimensional atten- tion deficit hyperactivity disor...

Ngày tải lên: 08/08/2014, 23:21

... metalloproteinase (MMP) expression and activation in the medium were analysed by gelatin zymography, proteoglycan release by the dimethylmethylene blue assay, and cell viability by the Cytotox 96 ® assay. ... primary chondrocytes and chondrocyte cell lines results in increased apoptosis and caspase activity [43,44]. Since we have previously shown that TNF-α increases PACT pr...

Ngày tải lên: 09/08/2014, 01:23

... IL-16 and RANTES in RASFs provoking chemoattraction of T cells. The data demonstrate, for the first time, a bridging link between B -cell activity and T -cell trafficking. In addition, they are ... RA. They demonstrate clearly that antibodies may interact directly with fibroblast-like cells and through this interaction form part of a signalling loop that ultimately results in...

Ngày tải lên: 09/08/2014, 06:22

... MMP-3 and MMP-13 in human and bovine chondrocyte cell lines IL-1β potently induced expression of the genes encoding MMP-3 and MMP-13 in the human chondrocytic cell line SW1353 and in primary human ... prevents the binding of Sp1 to its cognate DNA [19]. MMP-3 and MMP-13 induction by the three major inflammatory cytokines and inhibition by mithramycin imply that inter...

Ngày tải lên: 09/08/2014, 06:22